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  1. 8941
    por Li, Guo, Tian, Yuan, Zhu, Wei-Guo
    Publicado 2020
    “…We also highlight potential avenues to use HDACi as novel, precision cancer treatments.…”
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    The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
  2. 8942
    “…[Image: see text] In this study, we synthesized and characterized a silicon phthalocyanine substituted with 3-hydroxypyridin-2-thione (SiPc-HDACi), designed to be a chemophotodynamic therapy agent acting as a histone deacetylase inhibitor, and we determined its photophysical, photochemical, and photobiological properties. …”
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    A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy
  3. 8943
    “…It is very likely that under conditions of the G1 arrest in the cell cycle, HDACi exhibit their actual antiviral potency, since their inherent anticancer activity that complicates the interpretation of test results is minimized.…”
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    Pre-Senescence Induction in Hepatoma Cells Favors Hepatitis C Virus Replication and Can Be Used in Exploring Antiviral Potential of Histone Deacetylase Inhibitors
  4. 8944
    “…To assess in individual-person meta-analyses how out-of-office blood pressure (BP) contributes to risk stratification and the management of hypertension, an international consortium set up the International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome. …”
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    What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?
  5. 8945
    “…Sensitivity of MYC-driven MB to class I histone deacetylase inhibitors (HDACi) has been previously demonstrated in vitro and in vivo. …”
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    Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells
  6. 8946
    “…We analyzed the activity of the histone deacetylase inhibitor (HDACi) suberoyl-anilide hydroxamic acid (SAHA) on Kasumi-1 acute myeloid leukemia (AML) cells expressing AML1/ETO. …”
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    Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells
  7. 8947
    “…Six-dose high-dose cytarabine (HiDAC-6), commonly used as a consolidation regimen, has never been evaluated as induction therapy. …”
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    Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia
  8. 8948
    “…We tested the activity of 2 new and 3 previously described HDACi with different class/isoform selectivity on human GBM cells. …”
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    Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells
  9. 8949
    “…Multi-pathway analysis was performed to investigate the effect of JAK1/2i and/or HDACi on JAK/STAT, Akt/mTOR and MAPK signalling pathways. …”
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    Ruxolitinib with resminostat exert synergistic antitumor effects in Cutaneous T-cell Lymphoma
  10. 8950
    “…Histone deacetylase inhibitors (HDACi) sensitize homologous recombination (HR)-proficient human ovarian cancer cells to PARP inhibitors (PARPi). …”
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    Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer
  11. 8951
    “…Dose responses in different PCa risk categories and HDACi properties of specific AED substances were further explored. 1738/31591 (5.5%) cases and 9674/156802 (6.2%) controls had been exposed to AED. …”
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    Use of Antiepileptic Drugs and Risk of Prostate Cancer: A Nationwide Case-Control Study in Prostate Cancer Data Base Sweden
  12. 8952
    por Roos, Wynand Paul, Krumm, Andrea
    Publicado 2016
    “…Throughout the review, we endeavor to identify the specific HDAC targeted by HDACi leading to therapy sensitization.…”
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    The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair
  13. 8953
    “…Despite the proven clinical antineoplastic activity of histone deacetylase inhibitors (HDACI), their effect has been reported to be lower than expected in B-cell lymphomas. …”
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    Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway
  14. 8954
    “…Histone deacetylase inhibitors (HDACi) are small molecules targeting epigenetic enzymes approved for hematologic neoplasms, which have also demonstrated clinical activities in solid tumors. …”
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    Inhibition of HDACs-EphA2 Signaling Axis with WW437 Demonstrates Promising Preclinical Antitumor Activity in Breast Cancer
  15. 8955
    por Zhang, Xuan, Su, Mingbo, Chen, Yi, Li, Jia, Lu, Wei
    Publicado 2013
    “…The SAR study indicated that the introduction of polar group such as hydroxamate on the 4-position of the quinazoline core is more likely to provide a potent HDACi/HER2i hybrid rather than HDACi/EGFRi molecule.…”
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    The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors
  16. 8956
    “…We determine the sequence-to-function-to-structure relationships of the NPC1 polypeptide fold required for membrane trafficking and generation of a tunnel that mediates cholesterol flux in late endosomal/lysosomal (LE/Ly) compartments. HDACi treatment reveals unanticipated epigenomic plasticity in SCV relationships that restore NPC1 functionality. …”
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    Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
  17. 8957
    “…Among >3,300 compounds, we identified multiple histone deacetylase inhibitors (HDACi) inducing enucleated cells from the cell line, although an increase in membrane fragility of enucleated cells was observed. …”
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    Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines
  18. 8958
    “…In this review, we summarize the mechanisms of renal fibrosis and the signaling pathways that might be involved in HDACs in renal fibrosis, and the specific mechanisms of action of various HDAC inhibitors (HDACi) in the anti-fibrotic process to elucidate HDACi as a novel therapeutic tool to slow down the progression of renal fibrosis.…”
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    Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression
  19. 8959
    por Li, Song, Wang, Baolu, Xu, Yan, Zhang, Junjie
    Publicado 2011
    “…These results reveal an internal HDACi-resistant mechanism in cancer cells, and suggest that the inhibition of ATX-LPA axis would be helpful to improve the efficacy of HDACi-based therapeutics against cancer.…”
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    Texto
    Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis
  20. 8960
    “…Histone deacetylase inhibitors (HDACi) have been evaluated in patients with Ewing sarcoma (EWS) but demonstrated limited activity. …”
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    Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways
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