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  1. 8961
    por Ni, Jieming, Ni, Anping
    Publicado 2021
    “…Besides, histone deacetylase inhibitor (HDACi) mitigates tumor growth via targeting HIF-1α, whereas underlying mechanism still requires investigation. …”
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    Online Artículo Texto
    Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system
  2. 8962
    “…Finally, we showed that combining HDACi with JQ1 acts synergistically in reducing cell viability of GS-lines. …”
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    Online Artículo Texto
    BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma
  3. 8963
    “…The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents. 1,25D and its analogs have potential in combination therapies because they exhibit synergistic activities with other anticancer agents such as histone deacetylase inhibitors (HDACi). We have developed a series of hybrid molecules that combine HDACi within the backbone of a VDR agonist and thus represent fully integrated bifunctional molecules. …”
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    Online Artículo Texto
    Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer
  4. 8964
    “…Moreover, cAMP agonist combined with HDACi also induced glioma stem cells (GSCs) to differentiate into neuron-like cells through the regulation of H3K9ac/K14ac, indicating that combined induction has the potential for recurrence-preventive application. …”
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    Online Artículo Texto
    Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell
  5. 8965
    por Hidary, Jack D
    Publicado 2019
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    Quantum computing
  6. 8966
    por Capizzi, R. L., White, C.
    Publicado 1988
    “…This metabolite/drug interaction could be termed "self-potentiation," a feature which contributes to the overall activity of HiDAC. Asparaginase enhances these effects in a schedule-dependent fashion by lowering the cellular pool size of dCTP and consequent enhanced metabolism of ara-C. …”
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    Texto
    The pharmacologic basis for the efficacy of high-dose Ara-C and sequential asparaginase in adult acute myelogenous leukemia.
  7. 8967
    “…To target these aberrations, epigenetic modulating agents, such as DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi), are under intense investigation in solid and hematological cancers. …”
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    Online Artículo Texto
    Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma
  8. 8968
    “…This observation may provide an explanation for the selective toxicity of HDACi against rapidly proliferating leukemic cells.…”
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    Online Artículo Texto
    Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells
  9. 8969
    “…Conversion with inhibitors of histone deacetylases (HDACi), NaB, TSA, or VPA, further increased Rex1 expression, while decreasing expression of exogenous genes. piPSCs induced by Tet1+OSKM followed by conversion with HDACi show high pluripotency. …”
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    Online Artículo Texto
    Epigenetic Modifiers Facilitate Induction and Pluripotency of Porcine iPSCs
  10. 8970
    “…Collectively we suggest that the combination of HDACi and BRD4i should be pursued in further pre-clinical testing.…”
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    Online Artículo Texto
    Suppression of BCL6 function by HDAC inhibitor mediated acetylation and chromatin modification enhances BET inhibitor effects in B-cell lymphoma cells
  11. 8971
    “…Surprisingly, patient's condition was improved after treatment with PD-1 inhibitor in combination with DNMTi/HDACi. Restaging PET revealed dramatically radiological response.…”
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    Online Artículo Texto
    Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion
  12. 8972
    “…Subsequently, we selected the most promising “capless” HDACi and transferred its ZBG to our previously published scaffold featuring a peptoid‐based cap group. …”
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    Online Artículo Texto
    Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors
  13. 8973
    “…Various molecules have been developed as HDAC inhibitors (HDACi), which have become potential antiepileptic drugs for epilepsy treatment. …”
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    Online Artículo Texto
    HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
  14. 8974
    “…In this study, we investigated whether the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) could induce HDP expression and the mechanism underlying NaB-regulated HDP expression in PK-15 cells. …”
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    Online Artículo Texto
    Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells
  15. 8975
    “…None were unexpected given the HiDAC/Mito regimen. Serious adverse events occurred in 6 (30%) patients; one was fatal. …”
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    Online Artículo Texto
    A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia
  16. 8976
    “…The primary study objective was the minimal residual disease (MRD)- based comparative assessment of cytotoxic efficacies of clofarabine 5x40 mg/m(2) versus high-dose cytarabine (HIDAC) 4x3g/m(2), both in combination with PEG-ASP 2,500 IU/m(2) as randomized intervention in early consolidation. …”
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    Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group.
  17. 8977
    “…Altering epigenetic status by applying histone deacetylase inhibitors (HDACi) enhances developmental potential of somatic cell nuclear transfer (SCNT) embryos. …”
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    Online Artículo Texto
    Oxamflatin Significantly Improves Nuclear Reprogramming, Blastocyst Quality, and In Vitro Development of Bovine SCNT Embryos
  18. 8978
    “…Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes. …”
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    Online Artículo Texto
    Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
  19. 8979
    “…Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. …”
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    Online Artículo Texto
    Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy
  20. 8980
    “…Similar effects are seen with histone deacetylase inhibitors (HDACi), albeit with poorer tolerance. Here, we show that bone marrow (BM) stromal cells (HS-5) protected MPN-derived cell lines (SET-2; HEL and UKE-1) and MPN patient-derived BM cells from the cytotoxic effects of Ruxolitinib and the HDACi Vorinostat. …”
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    Online Artículo Texto
    The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways
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