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  1. 9041
    “…The histone deacetylase inhibitor (HDACi) AR‐42 exhibited anti‐cachectic activity in this model. …”
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    Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor
  2. 9042
    “…In vitro epigenetic drug screening of 11 compounds showed that histone deacetylase inhibitors (HDACi) had the highest anti-proliferative activity in two PF-EPN-A patient-derived cell lines. …”
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    CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models
  3. 9043
    “…Administration of HDACi reduced HDAC activity and decreased expression of IKKε although its acetylation was increased. …”
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    Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade
  4. 9044
    “…Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor effects against several types of solid tumors. …”
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    Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer
  5. 9045
    “…However, incubation of NPICCs with class I histone deacetylase inhibitors (HDACi) mocetinostat and MS275, but not selective class II HDACi (TMP269, MC1568) mimicked the butyrate effect on beta cell differentiation. …”
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    Butyrate and Class I Histone Deacetylase Inhibitors Promote Differentiation of Neonatal Porcine Islet Cells into Beta Cells
  6. 9046
    “…We show here that allogenic or autologous murine iPSCs, combined with a histone deacetylase inhibitor (HDACi), are able to elicit major anti-tumor responses in a highly aggressive triple-negative breast cancer, as a relevant cancer stemness model. …”
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    Evidence of Antitumor and Antimetastatic Potential of Induced Pluripotent Stem Cell-Based Vaccines in Cancer Immunotherapy
  7. 9047
    “…In this work, the effect of the class I histone deacetylase inhibitor (HDACI) BG45 on synapse-related proteins was investigated in primary neurons from APP/PS1 transgenic mice. …”
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    A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway
  8. 9048
    “…The current review is focused on the applications of HDACi HBI-8000 in cancer therapy and its potential in combination with DDR agents.…”
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    HBI-8000, HUYABIO Lead Clinical Program, Is a Selective Histone Deacetylase Inhibitor With Therapeutic Benefits in Leukemia and in Solid Tumors
  9. 9049
    “…Una de las fases más importantes de la gestión de los recursos hídricos es asegurar mediante estrategias eficientes, que los habitantes cuenten con la suficiente agua para su uso personal y doméstico, como un derecho humano básico. …”
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    OPINIÓN Y PERCEPCIÓN LOCAL SOBRE LA DISPONIBILIDAD DEL AGUA Y SU GESTIÓN EN ZONCUANTLA, MUNICIPIO DE COATEPEC, VERACRUZ, MÉXICO
  10. 9050
    por Aquino Alvarez, Deyanira
    Publicado 2017
    Tesis Electrónico eBook
    Aprendizaje ubicuo en la educación virtual, el caso de la Facultad de Pedagogía-Xalapa de la Universidad Veracruzana : /
  11. 9051
    “…The mechanisms and immunotherapeutic effect of PARPi and HDACi in promoting HRD-EXCUTE was examined in vitro and in vivo. …”
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    Loss of HRD functional phenotype impedes immunotherapy and can be reversed by HDAC inhibitor in ovarian cancer
  12. 9052
    “…Here, we examined whether LP342, the lead candidate of a new generation of hydrazide-based HDAC inhibitors (HDACi), decreases hepatic IRI. METHODS: IR was induced by clamping blood vessels to ~70% of the livers of mice for 1 h. …”
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    LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice
  13. 9053
    “…Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. …”
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    Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
  14. 9054
    “…These results indicate that FLIP is a major inhibitor of SMC-mediated apoptosis in MPM, but that this inhibition can be overcome by the HDACi SAHA.…”
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    SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma
  15. 9055
    “…DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) are under investigation for the treatment of cancer, including the plasma cell malignancy multiple myeloma (MM). …”
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    The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma
  16. 9056
    “…Via mass spectrometry, we found that 60S-associated, but not, polysome-associated, RPL24 undergoes HDACi-induced acetylation on K27. Thus, RPL24 K27 acetylation may play a role in ribosome assembly. …”
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    RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth
  17. 9057
    “…In addition, we investigated several histone deacetylase inhibitors (HDACi) in combination with gene knockdown experiments (HDAC1-3, MLL). …”
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    Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL
  18. 9058
    “…Here we identify a synergistic interaction of the second-generation histone deacetylase inhibitor (HDACI) JNJ-26481585 and common chemotherapeutic drugs (i.e. …”
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    JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis
  19. 9059
    “…METHODS: In the present study we investigated the potential radiosensitizing effect of PCI-24781, a potent pan-histone deacetylase inhibitor (HDACi), on the SF188 and KNS42 cell lines of pediatric GBM. …”
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    The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines
  20. 9060
    “…Further, HDAC inhibitors (HDACi) blocked alcohol-induction of class I HDACs and modulated alcohol-induced oxidative stress related genes expressed by MDDCs. …”
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    Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat
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