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9121por Tyler, Christina R. Steadman, Smoake, Jane J. W., Solomon, Elizabeth R., Villicana, Estrella, Caldwell, Kevin K., Allan, Andrea M.“…Finally, mRNA expression levels of brain-derived neurotrophic factor, Bdnf, which has been implicated in the control of frontal cortical flexibility and is regulated by HDAC5, were elevated in DAE male mice and restored to normal levels following HDACi treatment. Levels of mRNA encoding glutamate receptor ionotropic NMDA type subunits, which have been linked to cognitive flexibility, were not related to the reversal learning deficit in the DAE mice and were not altered by HDACi treatments. …”
Publicado 2018
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9122por Natarajan, Umamaheswari, Venkatesan, Thiagarajan, Radhakrishnan, Vijayaraghavan, Samuel, Shila, Rasappan, Periannan, Rathinavelu, Appu“…Lately, histone deacetylase inhibitors (HDACi) such as suberoylanilide hydroxamic acid (SAHA, or vorinostat, MK0683) have been emerging as a new class of drugs with promising therapeutic benefits in controlling cancer growth and metastasis. …”
Publicado 2019
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9123por Valinciute, Gintvile, Ecker, Jonas, Selt, Florian, Hielscher, Thomas, Schmidt, Christin, Sigaud, Romain, Ridinger, Johannes, Gatzweiler, Charlotte, Picard, Daniel, Oppermann, Sina, Blattner-Johnson, Mirjam, Jones, David T W, Oehme, Ina, Kool, Marcel, Remke, Marc, Pfister, Stefan M, Witt, Olaf, Milde, Till“…After demonstrating that the MYC target gene PLK1 is significantly downregulated upon class I HDACi treatment, we hypothesized that inhibition of both HDACs and PLK1 could have synergistic effects. …”
Publicado 2021
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9124“…INTRODUCTION: Cruciferous vegetables are a rich source of sulforaphane (SFN), which acts as a natural HDAC inhibitor (HDACi). Our previous study found that HDACi could restore histone acetyltransferase/histone deacetylase (HAT/HDAC) balance in the cochlea and attenuate gentamicin-induced hearing loss in guinea pigs. …”
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9125por Wachholz, Vanessa, Mustafa, Al-Hassan M., Zeyn, Yanira, Henninger, Sven J., Beyer, Mandy, Dzulko, Melanie, Piée-Staffa, Andrea, Brachetti, Christina, Haehnel, Patricia S., Sellmer, Andreas, Mahboobi, Siavosh, Kindler, Thomas, Brenner, Walburgis, Nikolova, Teodora, Krämer, Oliver H.“…The beneficial pro-apoptotic effects of FLT3i and HDACi against leukemic cells with mutant FLT3 are associated with dose- and drug-dependent alterations of cell cycle distribution and DNA damage. …”
Publicado 2021
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9126“…Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. …”
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9127por Lepore, Ilaria, Dell’Aversana, Carmela, Pilyugin, Maxim, Conte, Mariarosaria, Nebbioso, Angela, De Bellis, Floriana, Tambaro, Francesco P., Izzo, Tiziana, Garcia-Manero, Guillermo, Ferrara, Felicetto, Irminger-Finger, Irmgard, Altucci, Lucia“…Here, we investigate BARD1 expression and function in human acute myeloid leukemias and its modulation by epigenetic mechanism(s) and microRNAs. We show that the HDACi (histone deacetylase inhibitor) Vorinostat reduces BARD1 mRNA levels by increasing miR-19a and miR-19b expression levels. …”
Publicado 2013
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9128“…Chidamide is a new oral isotype-selective histone deacetylase inhibitor (HDACi). It is proved to exert a well-characterized anticancer property in a wide range of hematological malignancies, especially lymphoma. …”
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9129por Zichittella, Chiara, Loria, Marco, Celesia, Adriana, Di Liberto, Diana, Corrado, Chiara, Alessandro, Riccardo, Emanuele, Sonia, Conigliaro, Alice“…ITF2357 (givinostat) is a histone deacetylase inhibitor (HDACi) that revealed a significant anti-tumor action by inducing apoptosis in different tumor models, including leukemia, melanoma, and glioblastoma. …”
Publicado 2023
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9130“…BACKGROUND: Recent studies indicated that histone deacetylase inhibitors (HDACi), a class of anticancer agents, are in addition to their ability of apoptosis induction also capable of provoking autophagy. …”
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9131por Brinkmann, Christel Rothe, Højen, Jesper Falkesgaard, Rasmussen, Thomas Aagaard, Kjær, Anne Sofie, Olesen, Rikke, Denton, Paul W., Østergaard, Lars, Ouyang, Zhengyu, Lichterfeld, Mathias, Yu, Xu, Søgaard, Ole Schmeltz, Dinarello, Charles, Tolstrup, Martin“…Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. …”
Publicado 2018
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9132por Pasquier, Amandine, Alais, Sandrine, Roux, Loic, Thoulouze, Maria-Isabel, Alvarez, Karine, Journo, Chloé, Dutartre, Hélène, Mahieux, Renaud“…In asymptomatic STLV-1 infected non-human primates, HDACi/AZT combination allows a strong decrease in the PVL. …”
Publicado 2018
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9133por Manzotti, Gloria, Torricelli, Federica, Donati, Benedetta, Sancisi, Valentina, Gugnoni, Mila, Ciarrocchi, Alessia“…METHODS: Proliferation assays and evaluation of RUNX2 mRNA levels by qRT-PCR were used to evaluate the effect of several HDACi and specific siRNAs on a panel of cancer cell lines. …”
Publicado 2019
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9134“…Histone deacetylases inhibitors (HDACi) are a group of small-molecule compounds with extensive anti-tumor activity. …”
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9135por Karagianni, Fani, Piperi, Christina, Casar, Berta, de la Fuente-Vivas, Dalia, García-Gómez, Rocío, Lampadaki, Kyriaki, Pappa, Vasiliki, Papadavid, Evangelia“…SIMPLE SUMMARY: The combination of Resminostat (HDACi) and Ruxolitinib (JAKi) exerted cytotoxic effects and inhibited proliferation of CTCL cell lines (MyLa, SeAx) in vitro. …”
Publicado 2022
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9136por Looi, Chin-King, Gan, Li-Lian, Sim, Wynne, Hii, Ling-Wei, Chung, Felicia Fei-Lei, Leong, Chee-Onn, Lim, Wei-Meng, Mai, Chun-Wai“…Since CTL-resistant PDAC had a higher expression of histone proteins and its acetylated proteins compared to its parental cells, we further investigated the impact of histone deacetylase inhibitors (HDACi) on CTL-mediated cytotoxicity in PDAC cells in vitro, namely SW1990 and BxPC3. …”
Publicado 2022
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9137por Goyal, Ashish, Bauer, Jens, Hey, Joschka, Papageorgiou, Dimitris N., Stepanova, Ekaterina, Daskalakis, Michael, Scheid, Jonas, Dubbelaar, Marissa, Klimovich, Boris, Schwarz, Dominic, Märklin, Melanie, Roerden, Malte, Lin, Yu-Yu, Ma, Tobias, Mücke, Oliver, Rammensee, Hans-Georg, Lübbert, Michael, Loayza-Puch, Fabricio, Krijgsveld, Jeroen, Walz, Juliane S., Plass, Christoph“…Here, we use deep RNA sequencing from cancer cell lines treated with DNA methyltransferase inhibitor (DNMTi) and/or Histone deacetylase inhibitor (HDACi), to assemble a de novo transcriptome and identify several thousand ERV-derived, treatment-induced novel polyadenylated transcripts (TINPATs). …”
Publicado 2023
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9138por Gao, Lu, Gao, Minjie, Yang, Guang, Tao, Yi, Kong, Yuanyuan, Yang, Ruixue, Meng, Xiuqin, Ai, Gongwen, Wei, Rong, Wu, Huiqun, Wu, Xiaosong, Shi, Jumei“…To explore an optimized combinational therapy, interactions between the irreversible proteasome inhibitor carfilzomib exhibiting a well-tolerated side-effect profile and histone deacetylase inhibitor (HDACi) panobinostat (LBH589) were examined in MM cells. …”
Publicado 2015
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9139por Wei, Tzu-Tang, Lin, Yu-Chin, Lin, Pei-Hua, Shih, Jin-Yuan, Chou, Chia-Wei, Huang, Wei-Jan, Yang, Yu-Chih, Hsiao, Pei-Wen, Chen, Ching-Chow“…C-Cbl up-regulation induced by HDACi is a potential strategy for NSCLC treatment.…”
Publicado 2015
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9140por Valiati, Fernanda E., Vasconcelos, Mailton, Lichtenfels, Martina, Petry, Fernanda S., de Almeida, Rosa M. M., Schwartsmann, Gilberto, Schröder, Nadja, de Farias, Caroline B., Roesler, Rafael“…Here we show that infusion of an HDAC inhibitor (HDACi), trichostatin A (TSA), into the BLA, enhanced consolidation of IA memory in rats when given at 1.5, 3, or 6 h posttraining, but not when the drug was infused immediately after training. …”
Publicado 2017
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