“…STUDY QUESTION: Is there a difference in DNA methylation status of imprinted genes in placentas derived from IVF conceptions where embryo culture was performed in human tubal fluid (HTF) versus G5 culture medium? SUMMARY ANSWER: We found no statistically significant differences in the mean DNA methylation status of differentially methylated regions (DMRs) associated with parentally imprinted genes in placentas derived from IVF conceptions cultured in HTF versus G5 culture medium. …”
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“…STUDY QUESTION: Can an artificial intelligence (AI)-based model predict human embryo viability using images captured by optical light microscopy? SUMMARY ANSWER: We have combined computer vision image processing methods and deep learning techniques to create the non-invasive Life Whisperer AI model for robust prediction of embryo viability, as measured by clinical pregnancy outcome, using single static images of Day 5 blastocysts obtained from standard optical light microscope systems. …”
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“…PRS-SZ was calculated using summary statistics from the PGC and corrected for the 10 principal components of the GWAS. …”
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“…Identifying how signaling networks are rewired in model systems of spontaneous origin can inspire therapeutic strategies in humans. PLAIN ENGLISH SUMMARY: Interleukin-12 is a key cytokine that promotes anti-tumor immunity, as it is secreted by antigen presenting cells to activate Natural Killer cells and T cells present within the tumor microenvironment. …”
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“…STUDY QUESTION: Are male factor infertility or remaining childless risk factors for unipolar depression among men in assisted reproductive technology (ART) treatment? SUMMARY ANSWER: Male factor infertility was not associated with a significantly increased risk of unipolar depression and men remaining childless did not have a significantly increased risk of developing unipolar depression compared to men in ART treatment who became fathers. …”
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“…An increase in contact frequency between residues Ser263, Thr267, Tyr285, and Leu707 at the allosteric site and residues Thr397, Pro398, Thr402, and Gln395 at the ATP binding TXE loop was observed. In summary, this study identified five potential orthosteric inhibitors and five allosteric modulators against PfProRS. …”
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“…STUDY QUESTION: What are the risk factors and prevalence of bowel fistula following surgical management of deep endometriosis infiltrating the rectosigmoid and how can it be managed? SUMMARY ANSWER: In patients managed for deep endometriosis of the rectosigmoid, risk of fistula is increased by bowel opening during both segmental colorectal resection and disc excision and rectovaginal fistula repair is more challenging than for bowel leakage. …”
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“…SIMPLE SUMMARY: Embryo transfer is a common procedure in rodent facilities related to rederivation protocols, recovery of cryopreserved embryos and production of genetically engineered animals. …”
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“…SIMPLE SUMMARY: All of the veterinary schools in Australia and New Zealand worked together to develop the online One Welfare learning and teaching portal (OWP) for sharing teaching resources to assist veterinary graduates to become leaders in animal welfare and ethics (AWE). …”
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“…METHODS: GP73 serum levels were retrospectively determined by a novel GP73 ELISA (QUANTA Lite(®) GP73, Inova Diagnostics, Inc., Research Use Only) in a large cohort of 632 consecutive patients with chronic viral and non-viral liver diseases collected from two tertiary Academic centers in Larissa, Greece (n = 366) and Debrecen, Hungary (n = 266). Aspartate aminotransferase (AST)/Platelets (PLT) ratio index (APRI) was also calculated at the relevant time points in all patients. …”
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“…SIMPLE SUMMARY: The use of restrictive nosebands in equestrian sports is of increasing concern to veterinarians and equitation scientists. …”
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“…SIMPLE SUMMARY: Stressful stimuli, both infectious and non-infectious, can modify and trigger an innate immune response and inflammation, via an attempt to restore a homeostatic state. …”
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“…SIMPLE SUMMARY: Philasterides dicentrarchi is a free-living ciliate that causes high mortality in marine cultured fish, particularly flatfish, and in fish kept in aquaria. …”
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“…The 1L cohort also had statistically significant reductions in all-cause ER visits, FS-related IP visits, and total, medical, all-cause ER and OP, and FS-related medical charges. PLAIN LANGUAGE SUMMARY: Knowledge of healthcare resource utilization (HCRU) and costs of care in patients taking anti-seizure drugs (ASDs) is required to inform prescribing and formulary decision-making. …”
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“…SIMPLE SUMMARY: PTEN is an important tumor suppressor that is frequently mutated in malignancy. …”
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“…SIMPLE SUMMARY: Feeding maternal animals divergent ratios of omega-6 (ω6) and omega-3 (ω3) fatty acids can change not only their health, physiological condition, and performance but also do the same for their offspring. …”
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“…STUDY QUESTION: Is earlier puberty more likely a result of adiposity gain in childhood than a cause of adiposity gain in adulthood? SUMMARY ANSWER: Pre-pubertal fat mass is associated with earlier puberty timing but puberty timing is not associated with post-pubertal fat mass change. …”
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“…STUDY QUESTION: How has the performance of the European regional register of the European IVF-monitoring Consortium (EIM)/European Society of Human Reproduction and Embryology (ESHRE) evolved from 1997 to 2016, as compared to the register of the Centres for Disease Control and Prevention (CDC) of the USA and the Australia and New Zealand Assisted Reproduction Database (ANZARD)? SUMMARY ANSWER: It was found that coherent and analogous changes are recorded in the three regional registers over time, with a different intensity and pace, that new technologies are taken up with considerable delay and that incidental complications and adverse events are only recorded sporadically. …”
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“…STUDY QUESTION: Is there a difference in dietary patterns among subfertile South Asian women undergoing frozen embryo transfer (FET)? SUMMARY ANSWER: Significant regional differences in dietary pattern exist among subfertile South Asian women undergoing FET. …”
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“…SIMPLE SUMMARY: In poultry farming, additives are sought after to ensure the living needs of birds, improve the health of birds, and improve growth performance. …”
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