“…SIMPLE SUMMARY: This study was conducted to investigate the effects of dietary supplementation with Bacillus megaterium 1259 (BM1259) on growth performance, nutrient digestibility, rumen fermentation, and blood biochemical parameters in Holstein bull calves. …”
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“…However, given the small evidence base, these findings should be treated with caution. PLAIN LANGUAGE SUMMARY: THERE ARE TOO FEW WELL‐DESIGNED STUDIES TO KNOW THE EFFECTS OF TEACH FOR AMERICA ON MATH, ENGLISH LANGUAGE ARTS, AND SCIENCE OUTCOMES OF K–12 STUDENTS IN THE USA: Teach For America (TFA) is an alternate route teacher preparation program that aims to address the decades‐long shortage of effective teachers in many rural and urban public schools for kindergarten through 12th grade (K–12), that serve the highest proportions of high‐poverty students across the USA. …”
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“…SIMPLE SUMMARY: In view of the rising demand for global health care, the traditional medical knowledge is experiencing significant attention to meet the public health needs of developing countries. …”
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“…SIMPLE SUMMARY: Sustainable wildlife management (SWM), based on traditional practice supported with advances in scientific knowledge and evolving economic and social circumstances, has shaped the global approach to wildlife management and policy. …”
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“…STUDY QUESTION: Can a targeted whole exome sequencing (WES) on a cohort of women showing a primary ovarian insufficiency (POI) phenotype at a young age, combined with a study of copy number variations, identify variants in candidate genes confirming their deleterious effect on ovarian function? SUMMARY ANSWER: This integrated approach has proved effective in identifying novel candidate genes unveiling mechanisms involved in POI pathogenesis. …”
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“…Neutropenia and acute kidney injury TEAEs were reported by 0 and 3 pts in the rescue arm, respectively. Table 1. Summary of patients from IAT-randomized group meeting criteria for entry into MBV rescue arm* [Image: see text] Table 2. …”
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“…Snapshot outcomes following CAB+RPV LA Q4W and Q8W at Week 48 in participants naive to CAB+RPV from ATLAS, FLAIR, and ATLAS-2M (ITT-E population) [Image: see text] Table 2. Safety summary through Week 48 following CAB+RPV LA Q4W and Q8W or comparator ART in participants naive to CAB+RPV from ATLAS, FLAIR, and ATLAS-2M [Image: see text] CONCLUSION: In US/CAN Phase 3/3b trial participants, CAB+RPV LA was highly effective and well tolerated, with outcomes consistent with the overall pooled population. …”
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“…Consistently, 11 out of 13 surviving patients have decreased plasma apo(a) concentration compared to the plasma collected during the onset of COVID-19 from the same individuals (the median values of the onset and recovery are 141.1 versus 106.5 μg/mL, p<0.001) (Figure D). In summary, our study shows lower tPA enzymatic activity and higher apo(a) concentration in SARS-CoV-2-positive hospitalized patients compared to SARS-CoV-2-negative hospitalized patients. …”
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“…When analyzing the subpopulations, we found that patients below 65 years reported improved physical health summaries (p-value 0.016), decreased fatigue (p-value < 0.001), less insomnia (p-value 0.002) and improved role functioning (p-value <0.001) during the first wave, reaching both statistical significance and the threshold of MID. …”
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“…SIMPLE SUMMARY: Eligible patients received PBS IMPT at a single institution. …”
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“…It is advisable to place the planning isocenter close to the spinal canal to further mitigate the rotational error. SUMMARY: We simulated various scenarios of patient setup errors with different rotational combinations of pitch and yaw with 1°, 2°, and 3°, respectively. …”
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“…STUDY QUESTION: Can transgender women cryopreserve germ cells obtained from their orchiectomy specimen for fertility preservation, after having used puberty suppression and/or hormonal treatment? SUMMARY ANSWER: In the vast majority of transgender women, there were still immature germ cells present in the orchiectomy specimen, and in 4.7% of transgender women—who all initiated medical treatment in Tanner stage 4 or higher—mature spermatozoa were found, which would enable cryopreservation of spermatozoa or testicular tissue after having used puberty suppression and/or hormonal treatment. …”
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“…STUDY QUESTION: Which classification system for endometriosis do clinicians use most frequently, and why? SUMMARY ANSWER: Even with a high uptake of the three existing endometriosis classification systems, most clinicians managing endometriosis would like a new simple surgical descriptive system for endometriosis. …”
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“…STUDY QUESTION: What are patients’ and fertility staff views of talking about possible IVF/ICSI failure and need for multiple cycles in treatment planning? SUMMARY ANSWER: Healthcare professionals (HCPs) typically plan treatment on a cycle-by-cycle basis but HCPs and patients see benefits in talking about possible IVF/ICSI failure and the consequent need for multiple cycles to better prepare patients for this possibility, to support them through treatment challenges and to foster a sense of collaboration with the clinic in achieving the shared goal of treatment success. …”
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“…Using participants as the unit of analysis, we fitted simplified univariable models for sensitivity and specificity separately, employing a random‐effects model to estimate the summary sensitivity and specificity at the current and commonly reported World Health Organization (WHO) threshold (≥ 1000 copies/mL). …”
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“…SIMPLE SUMMARY: Fishes have relatively younger chromosomes than mammals and birds, making them excellent models to study sex chromosome differentiation in teleosts. …”
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“…SIMPLE SUMMARY: Immune checkpoint inhibitors (ICIs) and radiotherapy (RT) are widely used for patients with brain metastasis (BM). …”
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“…Excluded were (i) opinion papers or commentaries; (ii) studies that reported qualitative data; (iii) studies with samples mainly consisting of HCW, participants with confirmed or probable COVID-19 infection, hospitalized patients, or patients with a disease or condition; and (iv) clinical trials or intervention studies. To yield summary statistics, prevalence rates and sample sizes were pooled across studies. …”
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“…STUDY QUESTION: Does adjuvant letrozole in ovarian stimulation for IVF decrease the uterine peristalsis frequency (UPF) prior to fresh embryo transfer (ET)? SUMMARY ANSWER: Adjuvant letrozole in ovarian stimulation for IVF does not reduce the UPF significantly prior to fresh ET. …”
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“…STUDY QUESTION: Does direct kisspeptin signaling in the oocyte have a role in the control of follicular dynamics and ovulation? SUMMARY ANSWER: Kisspeptin signaling in the oocyte plays a relevant physiological role in the direct control of ovulation; oocyte-specific ablation of kisspeptin receptor, Gpr54, induces a state of premature ovulatory failure in mice that recapitulates some features of premature ovarian insufficiency (POI). …”
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