“…We had insufficient data to estimate summary sensitivity and specificity of version 2.0 (smear‐positive and ‐negative specimens) or to compare accuracy of the two versions. …”
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“…We used the GRADE system to assess the quality of evidence for core comparisons, and created three 'Summary of findings' tables. MAIN RESULTS: We included an additional 38 trials (involving 1225 randomised participants) in this update, making a total of 94 trials in the review (involving 2983 randomised participants). …”
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“…However, in the long-term, direct costs of care may continue to increase, dictated by a rising IBD prevalence and increasing use of biologic therapies. KEY SUMMARY POINTS: 1. The costs of health care for patients with IBD are more than double those without IBD. 2. …”
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“…It may be preliminary to make conclusions about female representation in phase I clinical trials because it is not mandatory to register all phase I trials on clinicaltrials.gov, but further investigation will be conducted into FDA summary reports. Preliminary findings indicate that efforts to include female subjects may be effective in the subset of studies that reported their results. …”
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“…Hemispherx and AOP Orphan Pharmaceuticals have signed a marketing agreement for Ampligen® for the treatment of chronic fatigue syndrome for Austria, the Czech Republic, Poland and Hungary. In an arrangement between Hemispherx and Bioclones, Bioclones has certain marketing rights for Ampligen® in the Southern Hemisphere, UK and Ireland. …”
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“…Individual tests We calculated pooled results of individual tests for ID NOW (Abbott Laboratories) (5 evaluations) and Xpert Xpress (Cepheid Inc) (6 evaluations). Summary sensitivity for the Xpert Xpress assay (99.4%, 95% CI 98.0% to 99.8%) was 22.6 (95% CI 18.8 to 26.3) percentage points higher than that of ID NOW (76.8%, (95% CI 72.9% to 80.3%), whilst the specificity of Xpert Xpress (96.8%, 95% CI 90.6% to 99.0%) was marginally lower than ID NOW (99.6%, 95% CI 98.4% to 99.9%; a difference of −2.8% (95% CI −6.4 to 0.8)) AUTHORS' CONCLUSIONS: This review identifies early‐stage evaluations of point‐of‐care tests for detecting SARS‐CoV‐2 infection, largely based on remnant laboratory samples. …”
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“…STUDY QUESTION: How should endometriosis be diagnosed and managed based on the best available evidence from published literature? SUMMARY ANSWER: The current guideline provides 109 recommendations on diagnosis, treatments for pain and infertility, management of disease recurrence, asymptomatic or extrapelvic disease, endometriosis in adolescents and postmenopausal women, prevention and the association with cancer. …”
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“…Furthermore, NCRB releases summary annual data rather than weekly or monthly data to analyse trends (Important during COVID19). …”
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“…STUDY QUESTION: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, after first embryo transfer, when compared with the current policy of transferring fresh embryos? SUMMARY ANSWER: This study, although limited by sample size, provides no evidence to support the adoption of a routine policy of elective freeze in preference to fresh embryo transfer in order to improve IVF effectiveness in obtaining a healthy baby. …”
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“…SIMPLE SUMMARY: Ensuring “animal welfare” and “customer satisfaction” are crucial concerns in the modern slaughterhouse. …”
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“…This Campbell systematic review was published in 2018. EXECUTIVE SUMMARY/ABSTRACT: BACKGROUND: Increasing class size is one of the key variables that policy makers can use to control spending on education. …”
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“…Introduction: Physics and Its Relation to Computer and Internet Technologies  Physics, Silicon, and the "Magic" behind the Internet Age  A Zoomed-In Look inside a Computer       Timeline of Great Discoveries and Inventions in Physics and Computer and Communication Technologies  The Methods and Significance of Science       The Relation of Science and Information Technology    Social Impacts: Science and Technology       Mathematics: The Language of Science and Technology    The Utility of Mathematics in Science and Technology   Graphs                Precision and Significant Digits          Large and Small Numbers and Scientific Notation     Real-World Example 2.1: Precision of Display Pixels    Units for Physical Quantities          Proportionality              Binary Numbers              The Concept of Information           Exponential Growth   Social Impacts: The Exponential Change of Nearly EverythingMechanics: Energy Enables Information TechnologyFrom Looms to Computers        Speed, Acceleration, and Force        In-Depth Look 3.1: Distance Traveled under Constant Acceleration     Real-World Example 3.1: Seek Time of a Hard-Drive Head  In-Depth Look 3.2: Net Force Vectors        Real-World Example 3.2: Acceleration in Cathode-Ray TubesPrinciples of Mechanics            Real-World Example 3.3: Force on a Hard-Drive Head    The Physics of Energy            Friction and Thermal Energy          The Constancy of Energy           Units for Mechanics             Power                Real-World Example 3.4: Motion Sensors in LaptopsSocial Impacts: Scientific Thought and Methods Have Arguably Changed the Course of Human History More Than Anything ElseMatter and Heat: Cooling Computers is Required by the Physics of ComputationFrom Steam Engines to ComputersMatter and AtomsGases, Liquids, and SolidsIn-Depth Look 4.1: Size and Numbers of AtomsReal-World Example 4.1: Growing Silicon Crystals for Computer ChipsPressure in a GasPressure in a LiquidPumps, Current, and ResistanceReal-World Example 4.2: A Water-Pressure-Operated ComputerTemperature              The Ideal GasHeat and Thermal Energy TransferReal-World Example 4.3: Cooling Computer Chips    Principles of Thermodynamics: Extracting Work from Heat  Cooling Computers is Required by the Physics of Computation              Social Impacts: The Industrial Revolution and the Information Revolution               Electricity and Magnetism: The Workhorses of Information TechnologyElectricity and Magnetism Are the Basis of Computers and the Internet           Electric ChargeIn-Depth Look 5.1: The Concept of Plus and Minus Electric ChargeElectric Forces: Coulomb's LawIn-Depth Look 5.2: The Discovery of the ElectronElectric FieldsIn-Depth Look 5.3: Electric Field LinesElectric Current and ConductorsElectrical Energy and VoltageReal-World Example 5.1: Capacitor Computer MemoryResistors, Conductors, and Ohm's LawElectrical Power MagnetismElectromagnetism             Real-World Example 5.2: The Telegraph, Precursor to the Internet                In-Depth Look 5.4: Magnetic Materials and Data StorageSocial Impacts: Innovation and Public Support of ScienceDigital Electronics and Computer LogicThe "Reasoning" Abilities of ComputersConcepts of LogicElectronic Logic CircuitsLogic Operations and DiagramsUsing Logic to Perform ArithmeticImplementing Logic with Electromagnetic SwitchesSupplemental Section: Boolean Search of Databases    Chapter 7 Waves: Sound, Radio, and LightCommunicating with Sound, Radio, and Light     Simple Harmonic Motion           Damped and Complex Harmonic Motion       Driven Harmonic Motion and Resonance       In-Depth Look 7.1: Resonance Frequencies      Real-World Example 7.1: Crystal Oscillators and Microprocessor Clocks            WavesSimple Harmonic WavesInterference of WavesIn-Depth Look 7.2: Standing WavesSound WavesIn-Depth Look 7.3: BeatsWireless Radio WavesReal-World Example 7.2: AM RadioLet There Be Light WavesIn-Depth Look 7.4: Light PolarizationReal-World Example 7.3: LCD ScreensInterference of Light            Social Impacts: Music, Science and Technology     Analog and Digital CommunicationCommunication Systems: Analog and DigitalBasics of Analog RadioBasics of Digital Radio            The Maximum Rate of Transmitting DataMaximum Data RateFrequency Multiplexing and BandwidthIn-Depth Look 8.1: Signal ReconstructionQuantum Physics of Atoms and MaterialsAtoms, Crystals, and ComputersThe Quantum Nature of Electrons and AtomsThe Experiments behind Quantum TheoryIn-Depth Look 9.1: Spectrum of Hydrogen AtomsThe Spinning of ElectronsThe Principles of Quantum PhysicsBuilding Up the AtomsReal-World Example 9.1: Fluorescent LampsElectrical Properties of MaterialsIn-Depth Look 9.2: Origin of the Energy Gap in Silicon CrystalsIn-Depth Look 9.3: Atomic Nature of Magnetic DomainsSocial Impacts: Science, Mysticism, and Pseudo-Science  Semiconductor Physics: Transistors and CircuitsSilicon, Transistors, and Computers        Controlling the Conductivity of Silicon       p-n Junctions and Diodes          Real-World Example 10.1: A Simple Crystal AM Radio ReceiverTransistors              CMOS Computer Logic           In-Depth Look 10.1: Water-Effect Transistors     Miniaturization, Integrated Circuits, and Photolithography  In-Depth Look 10.2: Bipolar Transistors      Social Impacts: Labeling Every Object in the World   Digital Memory and ComputersPhysics, Memory, and Computers        Sequential Logic for Computer Memory      Feedback Example #1: NOT Loop        Feedback Example #2: One-Time Latch       Static Random-Access Memory         In-Depth Look 11.1: SRAM with Six Transistors    Dynamic Random-Access Memory       Nonvolatile Memory            In-Depth Look 11.2: Quantum Tunneling      Magnetic Tape and Hard Disk Memory       Optical Compact Disk Memory        Error Immunity of Digital Data         The Structure of a Computer          Hierarchy of Computer Memory         Heat-Imposed Limits of Computers      Representing Information in Computers using Codes  Coding Images             Data Compression            Photons: Light Detectors and Light Emitting DiodesLight, Physics, and TechnologyThe Quantum Nature of Light-PhotonsPower and Energy in LightAbsorption of Light by Atoms and Crystals (or "How Einstein Got His Nobel Prize")In-Depth Look 12.1: Inability of Constant Voltage to Accelerate Electrons in an Insulator       Real-World Example 12.1: Semiconductor Light DetectorsEmission of Light by Atoms and CrystalsReal-World Example 12.2: Light-Emitting DiodesSocial Impacts: Lighting the Darkness (Efficiently)Light and Optical Fibers for the InternetLight as a Communication MediumPropagation, Reflection and Transmission of LightLight in Transparent MediaRefraction of Light at a BoundaryReflection of Light at a BoundaryTotal Internal ReflectionPrisms and Speeds of Different Colored LightLenses and Curved MirrorsOptical Loss in Materials-The Clarity of Optical FiberLight GuidingOptical FibersLight Pulses in Optical FibersSocial Impacts: Total Immersion in a Sea of InformationLight Amplification and LasersAtoms and LasersThe Uniqueness of Laser LightAbsorption and Emission of Light by AtomsLaser ResonatorsIn-Depth Look 14.1: Laser Resonator FrequenciesHow a Laser WorksThe Helium-Neon LaserIn-Depth Look 14.2: Extreme Laser FactsVariable-Color Semiconductor LasersOvercoming Losses in Fiber-Optic SystemsQuantum Physics Description of LasersThe Semiconductor Diode LaserFiber-Optics CommunicationBandwidth and the Physics of WavesOverview of Fiber-Optical Communication SystemsModulating a Laser Beam with DataWavelength Multiplexing in Optical CommunicationThe Virtues of Lasers for Optical CommunicationHardware for Wavelength MultiplexingLaser Beam RoutingCommunication Networks and the InternetThe Physics behind the InternetThe Goals of Computer Communication NetworksNoise in Analog and Digital SystemsChallenges in NetworkingBroadcasting Networks and Switching NetworksFailure-Resistant CommunicationsWireless Mobile Cell Phone NetworksPropagation of Wireless Waves in TerrainSummary of Scientific Notation and UnitsSources and Credits for Quotes Used with PermissionGlossary.…”
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“…In addition, the improved Quality Control (QC) procedure is applicable to the reaction and impregnation procedures, and may allow to control the repeatability of obtained coil geometry. Comprehensive summary is given in chapter 9. This includes the description of obtained objectives and a recommended outline of future studies aiming for automated superconducting coil winding.…”
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“…STUDY QUESTION: Can in vitro maturation (IVM) and developmental competence of human oocytes be improved by co-culture with ovarian support cells (OSCs) derived from human-induced pluripotent stem cells (hiPSCs)? SUMMARY ANSWER: OSC-IVM significantly improves the rates of metaphase II (MII) formation and euploid Day 5 or 6 blastocyst formation, when compared to a commercially available IVM system. …”
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“…Additionally, here was a 3-fold (P<0.05) decrease in p-S6k levels and >10-fold increase in p-p38 MAPK level in (56)Fe vs control and (1)H-IR-AMI hearts, suggesting continuous decreases in the survival, proliferation and angiogenesis signaling (p-Akt and p-S6k) and increase in the apoptotic signaling (p-p38 MAPK) up to Day 7 post-AMI in (56)Fe-IR-AMI mice. In summary, our results revealed that by 1 and 3 months post-IR in IR + AGING, (56)Fe-IR but not (1)H-IR mice had worse cardiac function. …”
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“…Better outcome measures, studies of better quality and better reporting are all needed to improve the evidence base for antifungals for seborrhoeic dermatitis. PLAIN LANGUAGE SUMMARY: ANTIFUNGAL TREATMENTS APPLIED TO THE SKIN TO TREAT SEBORRHOEIC DERMATITIS: Background Seborrhoeic dermatitis is a chronic inflammatory skin condition found throughout the world, with rashes with varying degrees of redness, scaling and itching. …”
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“…Further multi-centre randomised trials evaluating the effects of in-service emergency care training on long-term outcomes (health professional practice and patient outcomes) are needed. PLAIN LANGUAGE SUMMARY: In-service training for health professionals to improve care of seriously ill newborns and children in low-income countries WHAT QUESTION WAS THE REVIEW ASKING? …”
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“…Prespecified adverse outcomes are included in 'Summary of findings' tables, with the best available estimate of the absolute frequency of each outcome in short‐term international travellers. …”
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“…We presented sensitivity and specificity in paired forest plots, in receiver operating characteristic space and in dumbbell plots. We estimated summary parameters using a bivariate random‐effects meta‐analysis whenever five or more primary studies were available, and whenever heterogeneity across studies was deemed acceptable. …”
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“…In this group, a polyfunctional T cell response was found in 4/19 patients (30.8%). 33.3% of patients with GVHD requiring ECP had a T cell response, compared with 42.9% in post HSCT without GVHD. Summary: Despite encouraging results of antibody and T cell response to a first vaccination dose in patients with chronic myeloid malignancies, these results raise concerns regarding the humoral and T cell responses to vaccination in patients post HSCT, recognised as a particularly immunosuppressed group. …”
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