Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability

por Devall, Matthew A.M., Casey, Graham
Publicado 2021

Up to your NEK2 in CIN

por Seachrist, Darcie D., Anstine, Lindsey J., Keri, Ruth A.
Publicado 2021

The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations

por Kulkarni, Aditya, McDermott, Joseph Ryan, Kathad, Umesh, Modali, Rama, Richard, Jean-Philippe, Sharma, Panna, Bhatia, Kishor
Publicado 2021

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas

por Desai, Chandni, Thomason, Jon, Kohlmeyer, Jordan L., Reisetter, Anna C., Ahirwar, Parmanand, Jahanseir, Khadijeh, Leidinger, Mariah, Ofori-Amanfo, Georgina, Fritchie, Karen, Velu, Sadanandan E., Breheny, Patrick, Quelle, Dawn E., Tanas, Munir R.
Publicado 2021

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC

por Montaudon, Elodie, El Botty, Rania, Vacher, Sophie, Déas, Olivier, Naguez, Adnan, Chateau-Joubert, Sophie, Treguer, Damien, de Plater, Ludmilla, Zemoura, Leïla, Némati, Fariba, Nicolas, André, Chapelier, Alain, Livartowski, Alain, Cairo, Stefano, Daniel, Catherine, Brevet, Marie, Marangoni, Elisabetta, Meseure, Didier, Roman-Roman, Sergio, Bieche, Ivan, Girard, Nicolas, Decaudin, Didier
Publicado 2021

Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth

por Sphyris, Nathalie, King, Cody, Hoar, Jonathan, Werden, Steven J., Vijay, Geraldine V., Miura, Naoyuki, Gaharwar, Akhilesh, Sarkar, Tapasree Roy
Publicado 2021

Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer

por Gudi, Radhika R., Janakiraman, Harinarayanan, Howe, Philip H., Palanisamy, Viswanathan, Vasu, Chenthamarakshan
Publicado 2021

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib

por Mohamed, Yehia I., Lee, Sunyoung, Xiao, Lianchun, Hassan, Manal M., Qayyum, Aliya, Hiatia, Rikita, Pestana, Roberto Carmagnani, Haque, Abedul, George, Bhawana, Rashid, Asif, Duda, Dan G., Elghazaly, Hesham, Wolff, Robert A., Morris, Jeffrey S., Yao, James, Amin, Hesham M., Kaseb, Ahmed O.
Publicado 2021

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra(®)

por White, Tracey, Szelinger, Szabolcs, LoBello, Janine, King, Amy, Aldrich, Jessica, Garinger, Nathan, Halbert, Matthew, Richholt, Ryan F., Mastrian, Stephen D., Babb, Cody, Ozols, Audrey A., Goodman, Laurie J., Basu, Gargi D., Royce, Thomas
Publicado 2021

Predicting clinical outcomes using cancer progression associated signatures

por Mamrot, Jared, Hall, Nathan E., Lindley, Robyn A.
Publicado 2021

Drug exposure: still relevant after all these years

por Gerber, David E., Putnam, William C.
Publicado 2021

Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens

por Vanarsa, Kamala, Enan, Shereen, Patel, Pooja, Strachan, Briony, Sam Titus, Anto Sam Crosslee Louis, Dennis, Aphrihl, Lotan, Yair, Mohan, Chandra
Publicado 2021

Immunotherapy and fatigue: what we know and what we don’t know

por Azeem Khan, Muhammad, Florou, Vaia, Swami, Umang
Publicado 2021

Is there a role for CDK 4/6 inhibitors in breast cancer brain metastases?

por Schlam, Ilana, Tolaney, Sara M.
Publicado 2021

Multigene tests for breast cancer: the physician’s perspective

por Cognetti, Francesco, Biganzoli, Laura, De Placido, Sabino, del Mastro, Lucia, Masetti, Riccardo, Naso, Giuseppe, Pruneri, Giancarlo, Santini, Donatella, Tondini, Carlo Alberto, Tinterri, Corrado, Tonini, Giuseppe, Barni, Sandro
Publicado 2021

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore

por Paradkar, Sateja, Herrington, James, Hendricson, Adam, Hewawasam, Piyasena, Plummer, Mark, Hoyer, Denton, Sundaram, Ranjini K., Surovtseva, Yulia V., Bindra, Ranjit S.
Publicado 2021

Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2

por Al-Salam, Suhail, Kandhan, Karthishwaran, Sudhadevi, Manjusha
Publicado 2021

Correction: Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

por Raninga, Prahlad V., Trapani, Giovanna Di, Vuckovic, Slavica, Bhatia, Maneet, Tonissen, Kathryn F.
Publicado 2021

A higher De Ritis ratio (AST/ALT) is a risk factor for progression in high-risk non-muscle invasive bladder cancer

por Fukui-Kawaura, Sachi, Kawahara, Takashi, Araki, Yushi, Nishimura, Reona, Uemura, Koichi, Namura, Kazuhiro, Mizuno, Nobuhiko, Yao, Masahiro, Uemura, Hiroji, Ikeda, Ichiro
Publicado 2021

Activation of plasmacytoid dendritic cells promotes AML-cell fratricide

por Fatehchand, Kavin, Mehta, Payal, Colvin, Christopher B., Buteyn, Nathaniel J., Santhanam, Ramasamy, Merchand-Reyes, Giovanna, Inshaar, Hafza, Shen, Brenda, Mo, Xiaokui, Mundy-Bosse, Bethany, Tridandapani, Susheela, Butchar, Jonathan P.
Publicado 2021