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3361por Thaiparambil, Jose, Amara, Chandra S., Sen, Subrata, Putluri, Nagireddy, El‐Zein, Randa“…METHODS: We used confocal microscopy, real‐time PCR, siRNA knockdown, and western blot to analyze centrosome clustering and declustering using normal lung bronchial epithelial and nonsmall‐cell lung cancer (NSCLC) cell lines. Also, we used Ingenuity Pathway Analysis software to identify novel pathways associated with centrosome clustering. …”
Publicado 2023
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3362por Miyahara, Kazusa, Hino, Mizuki, Shishido, Risa, Nagaoka, Atsuko, Izumi, Ryuta, Hayashi, Hideki, Kakita, Akiyoshi, Yabe, Hirooki, Tomita, Hiroaki, Kunii, Yasuto“…Finally, we conducted pathway analysis and upstream analysis using Ingenuity Pathway Analysis to clarify the functions and upstream regulators of symptom-related gene modules. …”
Publicado 2023
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3363por Peniche Silva, Carlos Julio, De La Vega, Rodolfo E., Panos, Joseph, Joris, Virginie, Evans, Christopher H., Balmayor, Elizabeth R., van Griensven, Martijn“…Later, target prediction for the aberrantly expressed miRNAs was performed by means of the Ingenuity Pathway Analysis, and the expression of mRNA targets relevant for enthesis healing was confirmed using qPCRs. …”
Publicado 2023
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3364por Gurbuz, Berivan, Guldiken, Nurdan, Reuken, Philipp, Fu, Lei, Remih, Katharina, Preisinger, Christian, Brůha, Radan, Leníček, Martin, Petrtýl, Jaromír, Reissing, Johanna, Aly, Mahmoud, Fromme, Malin, Zhou, Biaohuan, Karkossa, Isabel, Schubert, Kristin, von Bergen, Martin, Stallmach, Andreas, Bruns, Tony, Strnad, Pavel“…Unsupervised hierarchical clustering was performed with Perseus software and R. Ingenuity pathway analysis (IPA) suggested upstream regulators that were validated in liver tissues. …”
Publicado 2023
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3365por Zhou, Huanhuan, Yang, Lu, Lin, Xiao, Chan, Ting Fung, Lee, Nikki Pui-Yue, Tse, William Ka Fai, Zhang, Xing, Li, Rong, Lai, Keng Po“…To investigate the downstream targets of USP44 and the molecular mechanisms underlying its regulation of cell proliferation in HCC, we conducted a comparative transcriptomic analysis and identified a cluster of proliferation-related genes, including CCND2, CCNG2, and SMC3. Ingenuity Pathway Analysis further delineated the gene networks controlled by USP44 through the regulation of membrane proteins and receptors, enzymes, transcriptional factors, and cyclins involved in the control of cell proliferation, metastasis, and apoptosis in HCC. …”
Publicado 2023
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3366por Yang, Yuxian, Liu, Shiliang, Xie, Chunxia, Li, Qiaoqiao, Gao, Tiantian, Liu, Mengzhong, Xi, Mian, Zhao, Lei“…Proteins that are functionally related to TMED3 were recognized by Affymetrix microarray and Ingenuity Pathway Analysis (IPA). Functional verification experiments were performed to analyze the role of FAM60A (a protein functionally related to TMED3) in vitro. …”
Publicado 2023
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3367por González-Ramírez, Martha I., Cardona, Yurley T., Agudelo, María C., López, Carolina, Florez-Acosta, Juan J., Agudelo-Gamboa, Samuel, Garai, Jone, Li, Li, Orozco-Castaño, Carlos A., Zabaleta, Jovanny, Sánchez, Gloria I.“…Five miRNAs differentially expressed were validated by RT-qPCR in an independent set of FFPE tissues with a reviewed diagnosis of CIN2+ (n = 105) and ≤ CIN1 (n = 105). The Ingenuity Pathway Analysis (IPA) was conducted to identify mRNAs inversely correlated with the top 25 differentially expressed miRNAs. …”
Publicado 2023
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3368por Pirone, Andrea, Ciregia, Federica, Lazzarini, Giulia, Miragliotta, Vincenzo, Ronci, Maurizio, Zuccarini, Mariachiara, Zallocco, Lorenzo, Beghelli, Daniela, Mazzoni, Maria Rosa, Lucacchini, Antonio, Laura, Giusti“…Moreover, the protein data set of CLA vs PU comparison was analyzed by Ingenuity Pathways Analysis to obtain a prediction of most significant canonical pathways, upstream regulators, human diseases, and biological functions. …”
Publicado 2023
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3369por Provasek, Vincent E., Kodavati, Manohar, Guo, Wenting, Wang, Haibo, Boldogh, Istvan, Van Den Bosch, Ludo, Britz, Gavin, Hegde, Muralidhar“…Functional enrichment analyses of DEGs indicated pathways associated with neuronal development and carcinogenesis that were likely altered by FUS mutations. Ingenuity Pathway Analysis (IPA) and GO network analysis of lncRNA-targeted mRNAs indicated associations related to RNA metabolism, lncRNA regulation, and DNA damage repair. …”
Publicado 2023
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3370por Honda, Hiroshi, Nishimichi, Norihisa, Kaneko, Mayumi, Yamashita, Michinori, Akimoto, Yumiko, Tanimoto, Hirotoshi, Teramoto, Mitsue, Teramoto, Hideki, Yokosaki, Yasuyuki“…We performed a gene ontology (GO) analysis and Ingenuity pathway analysis using these data. To validate the microarray data, we performed real-time RT-PCRs and immunohistochemistry for the differentially expressed genes between the two groups. …”
Publicado 2023
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3371por Peyton, Mina P., Yang, Tzu-Yi, Higgins, LeeAnn, Markowski, Todd W., Murray, Kevin, Vue, Cha, Parker, Laurie L., Lowe, Dawn A.“…Comparative analyses between Ovx/Sham and OA/YA using Ingenuity Pathway Analysis (IPA) found parallel patterns of inhibition and activation across IPA-defined canonical signaling pathways and physiological functional analysis, which were similarly observed in downstream GO, KEGG, and Reactome pathway overrepresentation analysis pertaining to muscle structural integrity and contraction, including AMPK and calcium signaling. …”
Publicado 2023
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3372“…These observations can be explained by the older adults’ subjective health perceptions arising from their ingenuous understanding of their health, which indirectly influences their smoking behavior to some extent. …”
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3373por Picard, Daniel, Felsberg, Jörg, Langini, Maike, Stachura, Paweł, Qin, Nan, Macas, Jadranka, Reiss, Yvonne, Bartl, Jasmin, Selt, Florian, Sigaud, Romain, Meyer, Frauke-D., Stefanski, Anja, Stühler, Kai, Roque, Lucia, Roque, Rafael, Pandyra, Aleksandra A., Brozou, Triantafyllia, Knobbe-Thomsen, Christiane, Plate, Karl H., Roesch, Alexander, Milde, Till, Reifenberger, Guido, Leprivier, Gabriel, Faria, Claudia C., Remke, Marc“…Patients with Group 1 tumors were significantly younger and showed worse progression-free survival compared to patients with group 2 tumors. Ingenuity pathways analysis (IPA) and gene set enrichment analysis (GSEA) revealed that Group 1 tumors were enriched for immune response pathways, such as interferon signaling, while Group 2 tumors showed enrichment for action potential and neurotransmitter signaling pathways. …”
Publicado 2023
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3374por Smith, Brandon C., Tinkey, Rachel A., Brock, Orion D., Mariam, Arshiya, Habean, Maria L., Dutta, Ranjan, Williams, Jessica L.“…Here, we performed RNA sequencing and ingenuity pathway analysis on IFNγ-treated astrocytes and found that PD-L1 was prominently expressed. …”
Publicado 2023
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3375por Provasek, Vincent E., Kodavati, Manohar, Guo, Wenting, Wang, Haibo, Boldogh, Istvan, Van Den Bosch, Ludo, Britz, Gavin, Hegde, Muralidhar L.“…Functional enrichment analyses of DEGs indicated pathways associated with neuronal development and carcinogenesis as likely altered by these FUS mutations. Furthermore, ingenuity pathway analysis (IPA) and GO network analysis of lncRNA-targeted mRNAs indicated associations between RNA metabolism, lncRNA regulation, and DNA damage repair. …”
Publicado 2023
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3376por Toprak, Muge, Yuksel, Nursen, Akpinar, Gurler, Kasap, Murat, Pirhan, Dilara, Tugan, Busra Yilmaz“…Aqueous humor (AH) from patients with PEX and cataracts was also collected for a comprehensive study of the data; ingenuity pathway analysis (IPA) was used for the discovered proteins. …”
Publicado 2023
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3377por Fortéa, José Osorio y, de La Llave, Emilie, Regnault, Béatrice, Coppée, Jean-Yves, Milon, Geneviève, Lang, Thierry, Prina, Eric“…Comparable fold-change values were obtained between the Affymetrix technology and the RTQPCR method. Ingenuity Pathway Analysis software(® )pinpointed the up-regulation of the sterol biosynthesis pathway (p-value = 1.31e-02) involving several genes (1.95 to 4.30 fold change values), and the modulation of various genes involved in polyamine synthesis and in pro/counter-inflammatory signalling. …”
Publicado 2009
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3378por Hedegaard, Jakob, Arce, Cristina, Bicciato, Silvio, Bonnet, Agnès, Buitenhuis, Bart, Collado-Romero, Melania, Conley, Lene N, SanCristobal, Magali, Ferrari, Francesco, Garrido, Juan J, Groenen, Martien AM, Hornshøj, Henrik, Hulsegge, Ina, Jiang, Li, Jiménez-Marín, Ángeles, Kommadath, Arun, Lagarrigue, Sandrine, Leunissen, Jack AM, Liaubet, Laurence, Neerincx, Pieter BT, Nie, Haisheng, Poel, Jan van der, Prickett, Dennis, Ramirez-Boo, María, Rebel, Johanna MJ, Robert-Granié, Christèle, Skarman, Axel, Smits, Mari A, Sørensen, Peter, Tosser-Klopp, Gwenola, Watson, Michael“…The following tools were used: Ingenuity Pathway Analysis, MAPPFinder, LIMMA, GOstats, GOEAST, GOTM, Globaltest, TopGO, ArrayUnlock, Pathway Studio, GIST and AnnotationDbi. …”
Publicado 2009
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3379por Saris, Christiaan GJ, Horvath, Steve, van Vught, Paul WJ, van Es, Michael A, Blauw, Hylke M, Fuller, Tova F, Langfelder, Peter, DeYoung, Joseph, Wokke, John HJ, Veldink, Jan H, van den Berg, Leonard H, Ophoff, Roel A“…Our findings were replicated in a second (30 patients and 30 controls) and third dataset (63 patients and 63 controls), thereby demonstrating a highly significant and consistent association of two large co-expression modules with ALS disease status. Ingenuity Pathway Analysis of the ALS related module genes implicates enrichment of functional categories related to genetic disorders, neurodegeneration of the nervous system and inflammatory disease. …”
Publicado 2009
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3380por Lonergan, Kim M., Chari, Raj, Coe, Bradley P., Wilson, Ian M., Tsao, Ming-Sound, Ng, Raymond T., MacAulay, Calum, Lam, Stephen, Lam, Wan L.“…METHODOLOGY/PRINCIPAL FINDINGS: Through the construction and analysis of SAGE libraries, we have determined transcriptome profiles for preinvasive carcinoma-in-situ (CIS) and invasive squamous cell carcinoma (SCC) of the lung, and compared these with expression profiles generated from both bronchial epithelium, and precancerous metaplastic and dysplastic lesions using Ingenuity Pathway Analysis. Expression of genes associated with epidermal development, and loss of expression of genes associated with mucociliary biology, are predominant features of CIS, largely shared with precancerous lesions. …”
Publicado 2010
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