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4241por Rai, Muhammad Farooq, Sandell, Linda J., Zhang, Bo, Wright, Rick W., Brophy, Robert H.“…Based on disease-specific Ingenuity Pathways Analysis, gene transcripts associated with aging were enriched for bone/cartilage disease while the gene expression profile associated with BMI was enriched for growth-plate calcification and OA. …”
Publicado 2016
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4242por Chun, Sunwoo, Bamba, Takeshi, Suyama, Tatsuya, Ishijima, Tomoko, Fukusaki, Eiichiro, Abe, Keiko, Nakai, Yuji“…Evaluation of the upstream regulators of DEGs using Ingenuity Pathway Analysis indicated that PPARα was activated in the livers of HP diet-fed rats. …”
Publicado 2016
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4243“…Two hybrids, mRMR + SVM and mRMR + BN, were the best models when tested on other datasets, and they achieved a prediction accuracy of 95.27% and 91.99%, respectively, compared to other mRMR hybrid models (mRMR + RF, mRMR + NB, mRMR + REPT, and mRMR + MLP). Ingenuity pathway analysis was used to analyze the functions of the 30 genes selected for this model and their potential association with CRC: CDH3, CEACAM7, CLDN1, IL8, IL6R, MMP1, MMP7, and TGFB1 were predicted to be CRC biomarkers. …”
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4244por Pinilla-Vera, Miguel, Xiong, Zeyu, Zhao, Yutong, Zhao, Jing, Donahoe, Michael P., Barge, Suchitra, Horne, William T., Kolls, Jay K., McVerry, Bryan J., Birukova, Anastasiya, Tighe, Robert M., Foster, W. Michael, Hollingsworth, John, Ray, Anuradha, Mallampalli, Rama, Ray, Prabir, Lee, Janet S.“…LPS induced a robust type I interferon transcriptional response and Ingenuity Pathway Analysis predicted interferon regulatory factor (IRF)7 as the top upstream regulator of 89 known gene targets. …”
Publicado 2016
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4245por Shinozaki, Fumika, Abe, Takashi, Kamei, Asuka, Watanabe, Yuki, Yasuoka, Akihito, Shimada, Kosuke, Kondo, Kaori, Arai, Soichi, Kumagai, Kota, Kondo, Takashi, Abe, Keiko“…Because the coordinated regulation of tissue transcriptomes implied the presence of upstream signaling common to these tissues, we conducted an Ingenuity Pathways Analysis. This analysis showed that estrogenic and glucagon signals were activated in the liver and WAT and that beta-adrenergic signaling was activated in all three tissues. …”
Publicado 2016
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4246“…We aligned >50 million 2X150 bp paired-end sequences/sample to the hg19 human genome and applied three different algorithms (Cuffdiff2, DEseq2, EdgeR) for identification of differentially expressed genes (DEG’s). Ingenuity Pathways Analysis (IPA) and Weighted Gene Co-expression Network Analysis (WGCNA) identified inflammatory processes as significantly elevated in our ALS samples, with tumor necrosis factor (TNF) found to be a major pathway regulator (IPA) and TNFα-induced protein 2 (TNFAIP2) as a major network “hub” gene (WGCNA). …”
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4247por Kadioglu, Onat, Cao, Jingming, Kosyakova, Nadezda, Mrasek, Kristin, Liehr, Thomas, Efferth, Thomas“…RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed. Chromosomal aberrations were identified by array-comparative genomic hybridisation (aCGH) and multicolour fluorescence in situ hybridisation (mFISH). …”
Publicado 2016
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4248por Rai, Richa, Chauhan, Sudhir Kumar, Singh, Vikas Vikram, Rai, Madhukar, Rai, Geeta“…The biological relevance of dysregulated transcripts in each SLE subsets was assessed by ingenuity pathway analysis (IPA) software. We observed that dysregulation in the transcriptome expression pattern was clearly distinct in each SLE patients subsets. …”
Publicado 2016
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4249por He, Shuang, Zhao, Tiechan, Guo, Hao, Meng, Yanzhi, Qin, Gangjian, Goukassian, David A., Han, Jihong, Gao, Xuimei, Zhu, Yan“…A cross talk between ischemia-induced angiogenesis and glucose tolerance pathways was analyzed by Ingenuity Pathway Analysis (IPA) which suggested an interaction of VEGF-A/VEGFR-2 and peroxisome proliferator-activated receptor δ (PPARδ)/peroxisome proliferator-activated receptor γ (PPARγ) genes. …”
Publicado 2016
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4250por Pegolo, Sara, Cecchinato, Alessio, Mach, Núria, Babbucci, Massimiliano, Pauletto, Marianna, Bargelloni, Luca, Schiavon, Stefano, Bittante, Giovanni“…Functional analyses using ClueGo and Ingenuity Pathway Analysis evidenced that DEGs in bovine liver were variously involved in energy reserve metabolic process, glutathione metabolism, and carbohydrate and lipid metabolism. …”
Publicado 2016
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4251por Slawinska, Anna, Plowiec, Arkadiusz, Siwek, Maria, Jaroszewski, Marcin, Bednarczyk, Marek“…Most of the differentially expressed genes (DEG) were detected in the cecal tonsils of P2 (378 DEG), and were assigned to gene ontology categories: lymphocyte proliferation, activation and differentiation, and cytokine production. Ingenuity pathway analysis of the DEG (CT of P2) indicated the inhibition of humoral and cellular immune responses, e.g., role of NFAT in regulation of immune responses, phagocytosis, production of nitric oxide, NF-κB, IL-8, and CXCR4 signaling. …”
Publicado 2016
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4252por Schüler-Toprak, Susanne, Häring, Julia, Inwald, Elisabeth C., Moehle, Christoph, Ortmann, Olaf, Treeck, Oliver“…Pathway and gene network analyses were performed by means of Genomatix and Ingenuity Pathway Analysis software. RESULTS: Invasiveness of MBA-MB-231 and HS578T breast cancer cells decreased after treatment with ERβ agonists ERB-041 and WAY200070. …”
Publicado 2016
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4253por Naga Prasad, Sathyamangla V., Gupta, Manveen K., Duan, Zhong-Hui, Surampudi, Venkata Suresh K., Liu, Chang-Gong, Kotwal, Ashwin, Moravec, Christine S., Starling, Randall C., Perez, Dianne M., Sen, Subha, Wu, Qingyu, Plow, Edward F., Karnik, Sadashiva“…To gain an unbiased perspective on global regulation by top eight altered miRNAs, functional relationship of predicted targets for these eight miRNAs were examined by network analysis. Ingenuity Pathways Analysis network algorithm was used to build global signaling networks based on the targets of altered miRNAs which allowed us to identify participating networks and nodal molecules that could contribute to cardiac pathophysiology. …”
Publicado 2017
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4254por Rohena-Rivera, Krizia, Sánchez-Vázquez, María M., Aponte-Colón, Diana A., Forestier-Román, Ingrid S., Quintero-Aguiló, Mario E., Martínez-Ferrer, Magaly“…In addition, we employed a microarray approach using the Affymetrix Hugene 2.0 ST array chip followed by analysis with Ingenuity Pathways Analysis (IPA) software. In vitro studies showed that IL-15 decreased PCa cell motility at both concentrations. …”
Publicado 2017
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4255por Tsai, Yi-Fang, Tseng, Ling-Ming, Hsu, Chih-Yi, Yang, Muh-Hwa, Chiu, Jen-Hwey, Shyr, Yi-Ming“…Furthermore, decreased migratory activity was found for △BDNF and △TrkB cell lines. Ingenuity pathway analysis (IPA) of MDA-MB-231 cells showed that BDNF is a key factor that is able to regulate a network made up of metalloproteases and calmodulin. …”
Publicado 2017
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4256por Reyes-Gibby, Cielito C., Melkonian, Stephanie C., Wang, Jian, Yu, Robert K., Shelburne, Samuel A., Lu, Charles, Gunn, Gary Brandon, Chambers, Mark S., Hanna, Ehab Y., Yeung, Sai-Ching J., Shete, Sanjay“…It is expected that multiple genes are involved in the formation, severity, and persistence of mucositis. We used Ingenuity Pathway Analysis (IPA), a novel network-based approach that integrates complex intracellular and intercellular interactions involved in diseases, to systematically explore the molecular complexity of mucositis. …”
Publicado 2017
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4257por Elam, Marshall B., Majumdar, Gipsy, Mozhui, Khyobeni, Gerling, Ivan C., Vera, Santiago R., Fish-Trotter, Hannah, Williams, Robert W., Childress, Richard D., Raghow, Rajendra“…To identify putative gene expression and metabolic pathways that may be perturbed in skeletal muscles of patients with statin myalgia, we subjected DEGs to Ingenuity Pathways (IPA) and DAVID (Database for Annotation, Visualization and Integrated Discovery) analyses. …”
Publicado 2017
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4258“…Secondly, the DEGs obtained were mapped to the pathways downloaded from an ingenuity pathways analysis (IPA), to reveal the underlying relationship between the DEGs and pathways enriched by these DEGs. …”
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4259por Cui, Lin, Rashdan, Nabil A., Zhu, Dongxing, Milne, Elspeth M., Ajuh, Paul, Milne, Gillian, Helfrich, Miep H., Lim, Kelvin, Prasad, Sai, Lerman, Daniel A., Vesey, Alex T., Dweck, Marc R., Jenkins, William S., Newby, David E., Farquharson, Colin, Macrae, Vicky E.“…Through bioinformatic analysis using Ingenuity Pathway Analysis (IPA), the up‐regulation of canonical signaling pathways relevant to cardiovascular function were identified in calcifying VIC‐derived MVs, including aldosterone, Rho kinase, and metal binding. …”
Publicado 2017
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4260“…This gene set was analysed with the BioLayout Express(3D) and Ingenuity Pathway Analysis software and relevant biological pathways and networks were identified. …”
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