“…On the other hand, some isoforms, lacking those functional domains, are reported to be repressors that make heterodimers with activator isoforms. The complex and ingenious function for CREB1 arises in part from the variation in their spliced isoforms, which allows them to interact with each other. …”
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“…In light of the click-chemistry paradigm which advocates the utilization of concise and selective carbon-heteroatom ligation reactions for the modular construction of useful compound libraries, the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction (CuAAC) has fueled enormous energy into the modern drug discovery. Recently, this ingenious chemical ligation tool has also revealed efficacious and expeditious in establishing large combinatorial libraries for the acquisition of novel PTPs inhibitors with promising pharmacological profiles. …”
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“…To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of pregnancy, we performed genome-wide DNA methylation profiling of human amnion from term (with and without labor) and preterm deliveries. Using the Illumina Infinium HumanMethylation27 BeadChip, we identified genes exhibiting differential methylation associated with normal labor and preterm birth. …”
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“…Due to the excellent performance of BiOI NFs array/TiO(2) NTs array and the ingenious signaling mechanism, the proposed system could achieve the sensitive and specific VEGF detection. …”
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“…Here we report a genome-wide association analysis of 567 winter wheat (Triticum aestivum) landrace accessions using the Infinium iSelect 9K wheat SNP array to identify loci associated with seedling resistance to five races of Pt (MDCL, MFPS, THBL, TDBG, and TBDJ) and one race of Pst (PSTv-37) frequently found in the Northern Great Plains of the United States. …”
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“…Noticeably, with the ingenious design procedure of our proposed algorithm, the computation complexity is reduced effectively. …”
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“…We applied this protocol to demonstrate MeDIP-Seq on the Ion Torrent platform provides adequate coverage of CpG cytosines, the methylation states of which we validated at single-base resolution on the Infinium HumanMethylation450 BeadChip array, and accurately identifies sites of differential DNA methylation. …”
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“…As technology involved, cost advantages of chip based genotyping was combined with information about rare variants, resulting in the Infinium HumanExome Beadchip. Using this chip, a sample of 493 patients with schizophrenia or schizoaffective disorder and 484 healthy controls was genotyped. …”
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“…Genotyping was performed using the Illumina BovineHD BeadChip according to the Infinium protocol. Moving average of -logP was used to map QTLs and Log drop was used to define their boundaries (QTLRs). …”
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“…Here, an intelligent framework is applied, encompassing epidemiological genome-scale DNA methylation data produced from the Illumina’s Infinium Human Methylation 450K Bead Chip platform, in an effort to correlate interesting methylation patterns with cancer predisposition and, in particular, breast cancer and B-cell lymphoma. …”
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“…Advances in the performances of many modern materials fundamentally depend upon the exploitation of new micro/nanostructures. Therefore, ingenious design of hierarchical structures through the mimicking of natural systems is of increasing importance. …”
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“…Therefore, a synergistic regulation of cations and anions at the interface is vital to promoting dendrite-free Li anodes. An ingenious molecular structure is designed to realize the “cation-anion regulation” with strong interactions between adsorption sites and ions at the molecular level. …”
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“…An important and difficult paradigm for motor function rehabilitation training is the movement rhythm on the shoulder, which is not a single joint but complex and ingenious combination of bones, muscles, ligaments, and tendons. …”
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“…Our micro-supercapacitors can be used as ingenious energy storage devices for future portable and wearable electronic applications.…”
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“…This work highlights the superiority of water-sensitive metal–organic frameworks in the ingenious design of hollow carbon materials incorporated with well-dispersed metal alloy NPs.…”
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“…Here, we describe a new version of our RnBeads software - an R/Bioconductor package that implements start-to-finish analysis workflows for Infinium microarrays and various types of bisulfite sequencing. …”
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“…This makes it an innovative and ingenious culture device that opens up new parameters for growing microaerobic microorganisms.…”
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“…Here, we reported an ingenious fabrication of moisture responsive graphene-based actuator via unilateral two-beam laser interference (TBLI) treatment of graphene oxide (GO) papers. …”
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“…Gene Set Enrichment Analysis (GSEA) is a general tool to aid biological interpretation, yet its correct and unbiased implementation in the EWAS context is difficult due to the differential probe representation of Illumina Infinium DNA methylation beadchips. RESULTS: We present a novel GSEA method, called ebGSEA, which ranks genes, not CpGs, according to the overall level of differential methylation, as assessed using all the probes mapping to the given gene. …”
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“…Genotyping was performed through an Illumina Infinium Genechip BARCBEAN6K_3 single nucleotide polymorphism (SNP) array. …”
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