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  1. 1
    “…Here, we show that the master melanocyte differentiation factor, microphthalmia transcription factor (MITF), regulates cell cycle exit by activating the cell cycle inhibitor INK4A, a tumor suppressor that frequently is mutated in melanomas. …”
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    MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
  2. 2
    por Hudack, Stephen, McMaster, Philip D.
    Publicado 1932
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    I. THE PERMEABILITY OF THE WALL OF THE LYMPHATIC CAPILLARY
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    A comparative evaluation of three methods for the rapid diagnosis of cryptococcal meningitis (CM) among HIV-infected patients in Northern Malawi
  4. 4
    “…After preparing an access cavity, K-file size #15 was introduced into the root canal and India ink was injected with an insulin syringe. Sixty samples were randomly divided in to experimental groups in group I (n=30), root canals were prepared with hand K-files; in group II (n=30), rotary Flex Master files were used for instrumentation, and in group III 8 remained samples were considered as negative controls. …”
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    Root Canal Cleaning Efficacy of Rotary and Hand Files Instrumentation in Primary Molars
  5. 5
    “…Mammalian target of rapamycin (mTOR) complexes, mTORC1 and mTORC2, are master regulators of cellular survival, growth and metabolism. …”
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    Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
  6. 6
    “…These include the cyclin-dependent kinase inhibitor (CDKI) p18(INK4c), the master transcriptional regulator of PC differentiation B lymphocyte-induced maturation protein-1 (BLIMP-1), and the cell surface antigens CD38 and CD138/Syndecan-1. …”
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    EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency
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    “…RESULTS: Histological analysis indicated localization of India ink to the suprachoroidal space below sclera, following injection. …”
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    Comparison of Suprachoroidal Drug Delivery with Subconjunctival and Intravitreal Routes Using Noninvasive Fluorophotometry
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    “…Hypoxia-mediated inhibition of PHF14 was associated with increase of key cell cycle inhibitors, p14(ARF), p15(INK4b), and p16(INK4a), which are responsible for G1-S phase transition and decrease of AKT-mTOR-4E-BP1/pS6K signaling pathway, a master regulator of protein synthesis, in response to environmental cues. …”
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    Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
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    “…METHODS: Using a small hypodermic 26G needle (3/8”) with a short bevel (250 µm), location of the suprachoroidal injection in an ex vivo New Zealand white rabbit eye model was confirmed with India ink. Ocular tissue distribution of NaF (25 µl of 1.5 µg/ml) at 37 °C was monitored noninvasively using the Fluorotron Master(TM) at 0, 1, and 3 h following suprachoroidal, intravitreal, or intracameral injections in ex vivo rabbit eyes. …”
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    Suprachoroidal delivery in a rabbit ex vivo eye model: influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes
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    “…After 7 days, samples were divided on the basis of calcium hydroxide removal method (Master apical file, Navi Tip FX, and F File) and obturating material (Activ GP and Gutta Flow). …”
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    Relationship between sealing ability of Activ GP and Gutta Flow and methods of calcium hydroxide removal
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    “…This identifies VEGF-A as the first pharmacologically pliable master pathway for human organ rejuvenation in vivo and demonstrates the potential of our humanized mouse model for clinically relevant aging research.…”
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    Human organ rejuvenation by VEGF-A: Lessons from the skin
  12. 12
    “…3D printing of polymeric foams by direct-ink-write is a recent technological breakthrough that enables the creation of versatile compressible solids with programmable microstructure, customizable shapes, and tunable mechanical response including negative elastic modulus. …”
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    3D printed cellular solid outperforms traditional stochastic foam in long-term mechanical response
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    “…Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is implicated in the pathogenesis of age-related disorders; however, little is known about the association between Nrf2 and premature biological aging in ESRD patients. …”
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    Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study
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    “…Landmark studies in laboratory mice have characterized a number of master senescence regulators, including p16(INK4a), p21, NF-κB, p53, and C/EBPβ. …”
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    A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence
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    “…NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles and oxidation, promotes NRF2 degradation in unstressed conditions. …”
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    RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding
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    “…Its effects in physiology and disease are believed to be linked to its role as a master regulator of epithelial-to-mesenchymal transition (EMT). …”
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    Non-canonical functions of SNAIL drive context-specific cancer progression
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    “…Analysis of publically available RNASeq on 32 AT/RT identified elevated expression of NRF2 (median expression 40.78, normal brain 18.81). NRF2 is a master regulator of cell’s stress response whose expression is correlated with therapy resistance and poor survival. …”
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    ATRT-23. THE DUAL mTORC1/2 INHIBITOR SAPANISERTIB DISRUPTS THE NRF2-MEDIATED STRESS RESPONSE AND COMBINES SYNERGISTICALLY WITH THE BH3 MIMETIC OBATOCLAX TO EXTEND AT/RT SURVIVAL
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    “…Mechanistically, the ablation of sex hormone signalling reduced the expression of transcription factor EB (Tfeb) and Tfeb target gene in MuSCs, suggesting that sex hormones directly induce the expression of Tfeb, a master regulator of the autophagy–lysosome pathway, and consequently autophagosome clearance. …”
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    The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance
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    “…In the process, a polydimethylsiloxane (PDMS) stamp was prepared by replica molding against the surfaces of fresh lotus leaves that functioned as masters. A dispersion of octadecylamine-modified reduced graphene oxide (ODA-RGO) in tetrahydrofuran (THF) was used as “ink”. …”
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    Superhydrophobic lotus-leaf-like surface made from reduced graphene oxide through soft-lithographic duplication
  20. 20
    “…It aims at producing a message to be imprinted as an ink trace left on a writing medium. The generated trajectory of the pen tip is made up of strokes superimposed over time. …”
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    The lognormal handwriter: learning, performing, and declining
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