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541“…AIM: The main target is evacuation; however, with evidence about the value of intrapleural instillation of different fibrinolytic agents still under evaluation, our aim was comparing the effectiveness and safety of intrapleural instillation of sodium bicarbonate (NaHCO(3)) in comparison with urokinase in patients with infected pleural effusion. …”
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542por Sayyed, Sharif Karim, Quraishi, Marzuqa, Jobby, Renitta, Rameshkumar, Neelamegam, Kayalvizhi, Nagarajan, Krishnan, Muthukalingan, Sonawane, Tareeka“…This comparative study will open new possibilities to guide the rational design of novel lead compounds for antiretroviral therapies (ARTs), more specifically the structure-based design of novel Integrase strand transfer inhibitors (INSTIs) that may possess a better resistance profile than present drugs. …”
Publicado 2023
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543por Rich, Shannan N., Nasta, Paola, Quiros-Roldan, Eugenia, Fusco, Paolo, Tondinelli, Alice, Costa, Cecilia, Fornabaio, Chiara, Mazzini, Nicola, Prosperi, Mattia, Torti, Carlo, Carosi, Giampiero“…BACKGROUND: Integrase strand transferase inhibitors (INSTI), including raltegravir (RAL), elvitegravir (ELV), and dolutegravir (DTG), have demonstrated better efficacy and tolerability than other combination antiretroviral therapy (cART) classes in clinical trials; however, studies of sustainability of INSTI-containing therapy in the long-term are sparse. …”
Publicado 2023
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545por Focà, Emanuele, Calcagno, Andrea, Calza, Stefano, Renzetti, Stefano, Chiesa, Annacarla, Siano, Matteo, De Socio, Giuseppe, Piconi, Stefania, Orofino, Giancarlo, Madeddu, Giordano, Cattelan, Anna Maria, Nozza, Silvia, Ferrara, Micol, Milic, Jovana, Celesia, Benedetto Maurizio, Castelli, Francesco, Guaraldi, Giovanni“…Overall, 483, 243 and 96 participants received DTG, RAL and EVG/c respectively as first InSTI. At the end of the follow up 6.4%, 21.1% and 22.9% participants discontinued DTG, RAL and EVG/c respectively. …”
Publicado 2021
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546“…BACKGROUND: Bacille Calmette-Guérin (BCG) instillation is recommended in patients with non-muscle-invasive bladder cancer who have intermediate-risk and high-risk tumors. …”
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547por Milcheski, Dimas, Clivatti, Gustavo, González, Carol, Santos, Rafael, Monteiro, Araldo, Gemperli, RolfEnlace del recurso
Publicado 2023
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548
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549“…Importantly, exposure of Cur-B competently reduced the expression of the Notch signaling cascade which may be the plausible cause behind Cur-B-instigated apoptotic cell death and cell cycle arrest in LNCaP cells. …”
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550por Sato, Kei, Fukui, Hiroko, Hagiwara, Yuji, Ogawa, Ryoji, Nishioka, Ayako, Numano, Takamasa, Sugiyama, Taiki, Kawabe, Mayumi, Mera, Yukinori, Yoneda, Tadashi“…The carbon fibers were administered to rats by intratracheal instillation at doses of 0, 0.016, 0.08, and 0.4 mg/kg (total doses of 0, 0.128, 0.64, and 3.2 mg/kg) once per week for eight weeks and the rats were observed for up to 2 years after the first instillation. …”
Publicado 2023
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551“…After intracerebral injection or nasal instillation of vesicular stomatitis virus in young or old mice, there was no evidence of a generalized, systemic or blood infection. 2. …”
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552
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553por Kobayashi, Norihiro, Naya, Masato, Mizuno, Kohei, Yamamoto, Kazuhiro, Ema, Makoto, Nakanishi, Junko“…The present study was conducted to assess the pulmonary and systemic responses in rats after intratracheal instillation of highly pure, well-dispersed, and well-characterized SWCNTs. …”
Publicado 2011
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554por Jackson, Petra, Hougaard, Karin Sørig, Boisen, Anne Mette Z., Jacobsen, Nicklas Raun, Jensen, Keld Alstrup, Møller, Peter, Brunborg, Gunnar, Gutzkow, Kristine Bjerve, Andersen, Ole, Loft, Steffen, Vogel, Ulla, Wallin, Håkan“…Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. …”
Publicado 2012
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555por Khin Hnin Si, May, Mitaka, Chieko, Tulafu, Miniwan, Abe, Shinya, Kitagawa, Masanobu, Ikeda, Satoshi, Eishi, Yoshinobu, Kurata, Shunichi, Tomita, Makoto“…CONCLUSIONS: The PARP inhibition attenuated lung-kidney crosstalk induced by intratracheal LPS instillation, partly via an inhibition of NF-κB dependent proinflammatory cytokines.…”
Publicado 2013
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556por Erdely, Aaron, Antonini, James M, Young, Shih-Houng, Kashon, Michael L, Gu, Ja K, Hulderman, Tracy, Salmen, Rebecca, Meighan, Terence, Roberts, Jenny R, Zeidler-Erdely, Patti C“…Rats were intratracheally instilled (ITI) with PBS or 2 mg of welding fume collected from a stainless steel weld. …”
Publicado 2014
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557por Sebban, Shulamit, Farago, Marganit, Rabinovich, Shiran, Lazer, Galit, Idelchuck, Yulia, Ilan, Lena, Pikarsky, Eli, Katzav, ShulamitEnlace del recurso
Publicado 2014
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558por Privalova, Larisa I., Katsnelson, Boris A., Loginova, Nadezhda V., Gurvich, Vladimir B., Shur, Vladimir Y., Beikin, Yakov B., Sutunkova, Marina P., Minigalieva, Ilzira A., Shishkina, Ekaterina V., Pichugova, Svetlana V., Tulakina, Ludmila G., Beljayeva, Svetlana V.“…We used stable water suspensions of copper oxide particles with mean diameter 20 nm and of particles containing copper oxide and element copper with mean diameter 340 nm to assess the pulmonary phagocytosis response of rats to a single intratracheal instillation of these suspensions using optical, transmission electron, and semi-contact atomic force microscopy and biochemical indices measured in the bronchoalveolar lavage fluid. …”
Publicado 2014
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560“…Intermittent negative pressure wound therapy with instillation (NPWTi) is starting to be used successfully to treat early periprosthetic infections of endoprostheses. …”
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