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  1. 10101
    “…BACKGROUND: Treating elderly breast cancer patients remains a challenge but the increasing availability of immunotherapeutic approaches instills optimism that these tumours may also be susceptible to immune control. …”
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    Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients
  2. 10102
    “…As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently needed. …”
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    Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
  3. 10103
    “…We undertook a retrospective baseline audit of 100 clinical records of patients was undertaken prior to the instigation of the quality improvement intervention, and four months post implementation. …”
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    Evaluation of an evidence based quality improvement innovation for patients with musculoskeletal low back pain in an accident and emergency setting
  4. 10104
    “…CONCLUSIONS: Fluorophotometry generally did not correlate with any other DED tests, even though it showed capability of differentiating between DED and normal eyes up to 30 min after fluorescein dye instillation. There may be an aspect of DED that is missed in the current regimen of DED tests and only captured with fluorophotometry. …”
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    Corneal permeability changes in dry eye disease: an observational study
  5. 10105
    “…Two wk after initiating feeding, mice were intranasally instilled with 1 mg cSiO(2) once per wk for 4 wk and maintained on experimental diets for an additional 12 wk. …”
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    Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption
  6. 10106
    “…Dementia symptoms often developed insidiously, with delayed disease acknowledgement and caregiver self-identification. …”
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    In the Information Age, do dementia caregivers get the information they need? Semi-structured interviews to determine informal caregivers’ education needs, barriers, and preferences
  7. 10107
    “…From the 4th year of follow-up after nephroureterectomy, multiple recurrent bladder tumors staged as Ta transitional cell carcinoma developed, and six transurethral resections of the bladder (TURB) with multiple intravesical instillations were performed without any evidence of metastases and upper tract recurrences. …”
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    Bladder chondrosarcoma plus urothelial carcinoma in recurred transitional cell carcinoma of the upper urinary tract: a case report and literature review
  8. 10108
    “…Animals were treated by intravesical instillation of interleukin-activated NK cells. Tumor response was evaluated longitudinally by non-invasive bioluminescence imaging. …”
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    Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells
  9. 10109
    “…The immunity to pp65(336-439) instigates autoimmunity, suggesting that pp65(336-439) contains crucial B cell epitope(s) for the development of nephritis. …”
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    B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice
  10. 10110
    “…BACKGROUND: Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. …”
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    Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma
  11. 10111
    por Fluyau, Dimy, Revadigar, Neelambika
    Publicado 2017
    “…On the contrary, it seems that its potential side effects outweigh the benefits, and severe and real health hazards can, insidiously, lead to death. Kratom clinical, psychological, and medical manifestations can be disturbing. …”
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    Biochemical Benefits, Diagnosis, and Clinical Risks Evaluation of Kratom
  12. 10112
    “…Onset of motor symptoms may be acute following encephalopathic crisis or insidious without apparent crisis. Additionally, so-called late-onset GA1 has been described in single patients diagnosed after the age of 6 years. …”
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    Extrastriatal changes in patients with late-onset glutaric aciduria type I highlight the risk of long-term neurotoxicity
  13. 10113
    “…CASE REPORT: A 40-year-old male presented with complain of swelling over the dorsum of left foot for the duration of 2 years and pain in that foot for 4 months. Swelling was insidious in onset and has progressively increased in size. …”
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    An Unusual Case of Giant Cell Tumor of First Metatarsal: A Rare Case Report and Review of Literature
  14. 10114
    “…RESULTS: ICR mice were intratracheally instilled with the kaolins (0.05 and 0.2 mg/mouse), and comet assay was performed on their lungs. …”
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    Effect of physicochemical character differences on the genotoxic potency of kaolin
  15. 10115
    “…BACKGROUND: Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by the insidiously progressive nature of sacroiliitis and spondylitis. …”
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    Monosodium urate crystal deposition associated with the progress of radiographic grade at the sacroiliac joint in axial SpA: a dual-energy CT study
  16. 10116
    “…Sprague-Dawley rats (8–10 weeks) were exposed to nano-TiO(2) via intratracheal instillation (20, 100, or 200 µg suspended per 250 µL of vehicle) 24 h prior to vascular assessments. …”
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    Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure
  17. 10117
    “…RESULTS: Disulfide HMGB1 elicited abdominal mechanical hypersensitivity 24 hours after intravesical (5, 10, 20 μg/150 μl) instillation. In contrast, all-thiol HMGB1 did not produce abdominal mechanical hypersensitivity in any of the doses tested (1, 2, 5, 10, 20 μg/150 μl). …”
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    Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4
  18. 10118
    “…METHODS: In two similar multicenter, randomized studies, patients received either nepafenac 0.1% or vehicle, instilled three times daily starting a day prior to surgery and continuing for 90 days postoperatively. …”
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    Efficacy of nepafenac ophthalmic suspension 0.1% in improving clinical outcomes following cataract surgery in patients with diabetes: an analysis of two randomized studies
  19. 10119
    “…PM(2.5) was given by intratracheal instillation every 2 days for 3 weeks. Aspirin, Vitamin C, and Vitamin E were given once a day by oral gavage for 3 weeks, and ozone was administered by intraperitoneal injection once a day for 3 weeks. …”
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    Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PM(2.5)) Pollution in Mice: Possible Protective Medications and Mechanisms
  20. 10120
    “…Pulmonary mechanics, inflammatory, and fibrotic changes were assessed 28 days after intranasal instillation of silica particles in Swiss–Webster mice. …”
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    LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A(2A) Receptor
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