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  1. 10121
    “…However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. …”
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    Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study
  2. 10122
    “…However, recent studies have hypothesized that lack of sleep may instigate internet use for leisure. To elucidate the potential effects of sleep time on internet use, we explored the different associations between sleep time and internet use according to its purpose. …”
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    Lack of sleep is associated with internet use for leisure
  3. 10123
    “…Female BALB/c mice received intratracheal instillation of 50 μL of saline (S groups) or papain (P groups, 10 IU/50 μl of saline) on days 1 and 7 of the experimental protocol. …”
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    Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema
  4. 10124
    “…Prior reports have focused on toxic metabolic byproducts and reactive oxygen species as instigators of cerebral inflammation and subsequent immune cell invasion leading to BBB breakdown. …”
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    Modeling and rescue of defective blood–brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients
  5. 10125
    “…SIMPLE SUMMARY: Scarcity of non-steroidal anti-inflammatory drugs (NSAID) to minimise the pain in sheep instigated the current study. The aim of this study was to know the pharmacokinetic parameters of salicylic acid in New Zealand sheep after administration of multiple intravenous and oral doses of sodium salicylate (sodium salt of salicylic acid). …”
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    Pharmacokinetics of Salicylic Acid Following Intravenous and Oral Administration of Sodium Salicylate in Sheep
  6. 10126
    “…In the murine model, increased expression of HO-1 in the lungs was observed after silica-instillation. Moreover, silica-medicated activation of extracellular signal-regulated kinase (ERK) in the lungs was attenuated in response to silica-induced HO-1 upregulation. …”
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    Regulatory role of heme oxygenase-1 in silica-induced lung injury
  7. 10127
    “…CONCLUSION: The present study reports for the first time that maternal inhalation exposure to Printex 90 carbon black induced dose-dependent denaturation of PVM and reactive astrocytes, similarly to the findings observed following maternal exposure to Printex 90 by airway instillation. Of note, some of the observed effects have striking similarities with those observed in mouse models of neurodevelopmental disorders. …”
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    Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
  8. 10128
    “…ALT containing Gentamicin (5 mg/2 mL) in 4% sodium citrate was instilled into each catheter lumen after HD. National Healthcare Safety Network (NHSN) criteria were used to define CRB. …”
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    2117. Catheter-related Bacteremia in Hemodialysis Patients on Antibiotic Lock Therapy: Are Antibiotic Locks Ineffective?
  9. 10129
    “…BACKGROUND: School-based breastfeeding education (SBBE) may help improve breastfeeding rates in the long term by instilling in young people a base of evidence-informed knowledge, skills, and attitudes that primes them to make informed decisions about infant feeding and to become positive change agents. …”
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    Getting schooled: teachers’ views on school-based breastfeeding education in Lebanon
  10. 10130
    “…BACKGROUND: Cancer cachexia is an insidious process characterized by muscle atrophy with associated motor deficits, including diaphragm weakness and respiratory insufficiency. …”
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    Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia
  11. 10131
    por Goodman, Miri
    Publicado 2019
    “…Analogous proteins to gliadin can be found in other cereal grains and can also instigate the autoimmune response characterized in celiac (Schalk, Lexhaller, Koehler, & Scherf, 2017). …”
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    MON-177 The Effect of Gluten Protein Components on Type 1 Diabetes and the Viability of Treatment with Antioxidants
  12. 10132
    por Motwani, Komal, Siraj, Elias
    Publicado 2019
    “…Introduction: Acromegaly is known to have a slow and insidious course. As a result, the diagnosis is made very late, and at the time of diagnosis most patients have macroadenomas. …”
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    SAT-468 Conversion of a Non-Secreting to a Growth Hormone-Secreting Pituitary Adenoma: A Case of Rapid Development of Acromegaly
  13. 10133
    “…We also placed a contralateral Ommaya reservoir to permit continued weekly intrathecal amphotericin B without violation of the shunt valve. With each instillation, the shunt was set to its highest setting to minimize CSF egress for 6 hours then reset to its “drainage” setting. …”
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    Invasive Cryptococcal Meningitis Presenting as a Skull Base Mass in An Immunocompetent Host: A Case Report
  14. 10134
    “…Bupivacaine 0.25% alone (BG; 2 mg/kg) or bupivacaine (same dose) with dexmedetomidine (BDG; 1 μg/kg) were instilled/splashed over the ovarian pedicles and caudal aspect of uterus before ovariohysterectomy. …”
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    Analgesic Efficacy of Bupivacaine or Bupivacaine-Dexmedetomidine After Intraperitoneal Administration in Cats: A Randomized, Blinded, Clinical Trial
  15. 10135
    “…Occupational exposure to respirable crystalline silica (cSiO(2)) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO(2) triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, dietary supplementation with the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) abrogates these responses. …”
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    Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal
  16. 10136
    “…Methods: Male nude rats were whole body irradiated, intratracheally instilled with Calu-3 cancer cells and divided into six treatment arms (n = 20 each): no treatment (Group 1); intravenous nab-paclitaxel at 5.0 mg/kg once weekly for 3 weeks (Group 2); IH NanoPac at 0.5 or 1.0 mg/kg, once weekly for 4 weeks (Groups 3 and 4), or twice weekly for 4 weeks (Groups 5 and 6). …”
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    Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer
  17. 10137
    “…METHODS: Two-week-old infants were vaccinated with a single dose of Mnull RSV (8 × 10(7) vaccine units) or a sham preparation instilled into an endotracheal tube. Infants were observed continuously for signs of rapid breathing using infrared cameras. …”
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    2770. Intrapulmonary Vaccination with an M Protein-Deficient Respiratory Syncytial Virus (RSV) Vaccine Protects Infant Baboons Against an RSV Challenge
  18. 10138
    “…METHODS: Rabbits were infected by endotracheal instillation of 1.8 mL of a standardized inoculum containing 9 × 10(7) CFU of PA clinical strain 6206 (predetermined 100% lethal dose). …”
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    2202. Validation of a Rabbit Model of Pseudomonas aeruginosa Acute Pneumonia
  19. 10139
    “…Aqueous humor samples were collected after 15, 30, 60, and 90 min from instillation and then detected by LC-MS/MS. Hyperosmotic insult significantly activated protein expression of inflammatory biomarkers, which were significantly modulated by HC treatment. …”
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    Ocular Pharmacological Profile of Hydrocortisone in Dry Eye Disease
  20. 10140
    “…Hepatocellular carcinoma (HCC) is generally considered one of the most common gastrointestinal malignant tumors, characterized by high invasiveness and metastatic rate, as well as insidious onset. A relationship between carcinogenicity and aberrant microRNA-139-5p (miR-139-5p) expression has been identified in multiple tumors while the specific molecular mechanisms of miR-139-5p in HCC have not yet been thoroughly elucidated. …”
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    Reduced expression of microRNA-139-5p in hepatocellular carcinoma results in a poor outcome: An exploration the roles of microRNA-139-5p in tumorigenesis, advancement and prognosis at the molecular biological level using an integrated meta-analysis and bioinformatic investigation
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