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10221por Geboers, Bart, Timmer, Florentine E. F., Ruarus, Alette H., Pouw, Johanna E. E., Schouten, Evelien A. C., Bakker, Joyce, Puijk, Robbert S., Nieuwenhuizen, Sanne, Dijkstra, Madelon, van den Tol, M. Petrousjka, de Vries, Jan J. J., Oprea-Lager, Daniela E., Menke-van der Houven van Oordt, C. Willemien, van der Vliet, Hans J., Wilmink, Johanna W., Scheffer, Hester J., de Gruijl, Tanja D., Meijerink, Martijn R.“…IRE transiently alters the tumor’s immunosuppressive microenvironment while simultaneously generating antigen release, thereby instigating an adaptive immune response. Combining IRE with immunotherapeutic drugs, i.e., electroimmunotherapy, has synergistic potential and might induce a durable antitumor response. …”
Publicado 2021
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10222por Mitsune, Ayumi, Yamada, Mitsuhiro, Fujino, Naoya, Numakura, Tadahisa, Ichikawa, Tomohiro, Suzuki, Ayumi, Matsumoto, Shuichiro, Mitsuhashi, Yoshiya, Itakura, Koji, Makiguchi, Tomonori, Koarai, Akira, Tamada, Tsutomu, Endo, Shota, Takai, Toshiyuki, Okada, Yoshinori, Suzuki, Satoshi, Ichinose, Masakazu, Sugiura, Hisatoshi“…We compared inflammatory cell accumulation and emphysematous changes induced by elastase instillation between wild-type and LILRB4-deficient mice. …”
Publicado 2021
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10223por Hass, Ethan W., Sorrentino, Zachary A., Xia, Yuxing, Lloyd, Grace M., Trojanowski, John Q., Prokop, Stefan, Giasson, Benoit I.“…These studies demonstrate significant disease-, region- and cell type specific differences in carboxy terminal αSyn processing associated with pathological inclusions that likely contributes to their distinct strain-like prion properties and promotes the diversity displayed in the degrees of these insidious diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40478-021-01242-2.…”
Publicado 2021
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10224por Saleem, Saniya, Baig, Anayat, Sajun, Sana, Bird, Victoria, Priebe, Stefan, Pasha, Aneeta“…Participants reported that the group meetings were seen as a safe space for shared learning, and that the experience helped improve self-regulation of emotions and behaviors and instilled a sense of belonging. CONCLUSION: Multi-family groups in community treatment of common mental health disorders facilitated by non-specialist mental health service providers is feasible, experienced positively and has the potential for large and positive effects on subjective quality of life, self-reported depression and anxiety, and objective social outcomes. …”
Publicado 2021
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10225por Ferro, Matteo, Del Giudice, Francesco, Carrieri, Giuseppe, Busetto, Gian Maria, Cormio, Luigi, Hurle, Rodolfo, Contieri, Roberto, Arcaniolo, Davide, Sciarra, Alessandro, Maggi, Martina, Porpiglia, Francesco, Manfredi, Matteo, Fiori, Cristian, Antonelli, Alessandro, Tafuri, Alessandro, Bove, Pierluigi, Terrone, Carlo, Borghesi, Marco, Costantini, Elisabetta, Iliano, Ester, Montanari, Emanuele, Boeri, Luca, Russo, Giorgio Ivan, Madonia, Massimo, Tedde, Alessandro, Veccia, Alessandro, Simeone, Claudio, Liguori, Giovanni, Trombetta, Carlo, Brunocilla, Eugenio, Schiavina, Riccardo, Dal Moro, Fabrizio, Racioppi, Marco, Vartolomei, Mihai Dorin, Longo, Nicola, Spirito, Lorenzo, Crocetto, Felice, Cantiello, Francesco, Damiano, Rocco, Di Stasi, Savino M., Marchioni, Michele, Schips, Luigi, Parma, Paolo, Carmignani, Luca, Conti, Andrea, Soria, Francesco, Gontero, Paolo, Barone, Biagio, Deho, Federico, Zaffuto, Emanuele, Papalia, Rocco, Scarpa, Roberto M., Pagliarulo, Vincenzo, Lucarelli, Giuseppe, Ditonno, Pasquale, Botticelli, Francesco Maria Gerardo, Musi, Gennaro, Catellani, Michele, de Cobelli, Ottavio“…We observed a significant delay between diagnosis and surgical treatment, with a lower adherence to the standard therapeutic scheme such as BCG intravesical instillation and urological guidelines. We also recorded a different attitude in treatment depending on the patients’ location in Italy. …”
Publicado 2021
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10226por Bai, Zhaofang, Li, Pengyan, Wen, Jincai, Han, Yanzhong, Cui, Yuanyuan, Zhou, Yongfeng, Shi, Zhuo, Chen, Shuaishuai, Li, Qiang, Zhao, Xu, Wang, Zhongxia, Li, Ruisheng, Guo, Yuming, Zhan, Xiaoyan, Xu, Guang, Ding, Kaixin, Wang, Jiabo, Xiao, Xiaohe“…MATERIALS AND METHODS: Mice were challenged with LPS (2 mg/kg) by intratracheal instillation (i.t.) and were orally administered Keguan-1 (low dose, 1.25 g/kg; medium dose, 2.5 g/kg; high dose, 5 g/kg) after 2 h. …”
Publicado 2022
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10227por Wang, Rui, Li, Hai-Chao, Li, Xu-Yan, Tang, Xiao, Chu, Hui-Wen, Yuan, Xue, Tong, Zhao-Hui, Sun, Bing“…Multivariate analysis showed that a baseline forced vital capacity (FVC) < 2.7 L (OR, 0.276; 95% CI, 0.083–0.919, p = 0.036) and a volume of fluid instilled > 60 ml (OR, 1.034; 95% CI, 1.002–1.067, p = 0.036) were independent risk factors for hypoxemia during bronchoscopy in the modified HFNC group. …”
Publicado 2021
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10228por Lin, Yifeng, Dong, Shunni, Ye, Xiaohang, Liu, Juan, Li, Jiaqun, Zhang, Yanye, Tu, Mixue, Wang, Siwen, Ying, Yanyun, Chen, Ruixue, Wang, Feixia, Ni, Feida, Chen, Jianpeng, Du, Binyang, Zhang, Dan“…In vitro studies were further conducted using EdU, transwell, tube formation, and western blot assays. RESULTS: Instilled HP-MSCs with HA hydrogel (HP-MSCs-HA) exhibited a prolonged retention time in mouse uteri than normal HP-MSCs. …”
Publicado 2022
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10229por Zhang, Yang, Huo, Fan, Cao, Qiang, Jia, Ru, Huang, Qiju, Wang, Zhu A, Theodorescu, Dan, Lv, Qiang, Li, Pengchao, Yan, Chao“…Postoperational intravesical instillation of BCG is carried out for patients with high-risk disease to reduce tumor recurrence and progression to muscle invasive disease. …”
Publicado 2022
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10230por de Zwart, A.E., Riezebos-Brilman, A., Lunter, G., Neerken, E., Van Leer, C., Alffenaar, J.C., Van Gemert, J.P., Erasmus, M.E., Gan, C.T., Kerstjens, H.A., Vonk, J.M., Verschuuren, E.A.“…PURPOSE: In April 2020 COVID-19 lockdown measures were instigated leading to a dramatic drop in non-COVID respiratory virus infections (RVI). …”
Publicado 2022
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10231por Liu, Junzhao, Wu, Zuohong, Liu, Yadong, Zhan, Zhu, Yang, Liping, Wang, Can, Jiang, Qinqin, Ran, Haitao, Li, Pan, Wang, Zhigang“…Compared with direct DMF instillation, DTP@DMF NPs treatment presented enhanced antifibrotic effect. …”
Publicado 2022
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10232por Molnár, Csilla, Gál, Judit, Szántó, Dorottya, Fülöp, László, Szegedi, Andrea, Siró, Péter, Nagy, Endre V., Lengyel, Szabolcs, Kappelmayer, János, Fülesdi, Béla“…METHODS: Consecutive patients admitted with the diagnosis of non-traumatic SAH were included. Intitial assessment consisted of cranial CT, Hunt-Hess, Fisher and WFNS scoring, 12-lead ECG, transthoracic echocardiography (TTE), transcranial duplex sonography and collecting laboratory parameters (CK, CK-MB, cardiac troponin T, NT-proBNP and urine metanephrine and normetanephrine). …”
Publicado 2022
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10233por Dhlamini, Qhaweni, Wang, Wei, Feng, Guifeng, Chen, Aiping, Chong, Lei, Li, Xue, Li, Quan, Wu, Jin, Zhou, Depu, Wang, Jie, Zhang, Hailin, Zhang, Jin-San“…To induce the ALI model, the mice were treated by intratracheal instillation of LPS (5 mg/kg). Then, histopathological changes in lung tissues were assessed by hematoxylin and eosin staining and transmission electron microscopy. …”
Publicado 2022
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10234por Yushan, Maimaiaili, Yalikun, Ainizier, Hamiti, Yimurang, Lu, Cheng, Yusufu, Aihemaitijiang“…CONCLUSION: The onset of wrist TB is insidious; early diagnosis, good patient compliance, and surgery combined with ATT are crucial steps for treatment of wrist TB, and also essential for the patient's postoperative recovery. …”
Publicado 2022
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10235por Wu, Dong-Ming, He, Miao, Zhao, Yang-Yang, Deng, Shi-Hua, Liu, Teng, Zhang, Ting, Zhang, Feng, Wang, Yuan-Yi, Xu, Ying“…METHODS: In this study, a mouse model of A. fumigatus infection after radiation was established by irradiating with 5 Gy on the chest and instilling 5 × 10(7)/ml Aspergillus fumigatus conidia into trachea after 24 h to explore the effect and study its function and mechanism. …”
Publicado 2022
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10236por Kang, Dong-Woo, Boulé, Normand G., Field, Catherine J., Fairey, Adrian S., Courneya, Kerry S.“…After the intervention, the HIIT group reported that HIIT was even more enjoyable (p < 0.001; d = 1.38), more motivating (p = 0.001; d = 0.89), more controllable (p < 0.001; d = 0.85), and instilled more confidence (p = 0.004; d = 0.66) than they had anticipated. …”
Publicado 2022
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10237por Pilankar, Aishwarya, Singhavi, Hitesh, Raghuram, Gorantla V., Siddiqui, Sophiya, Khare, Naveen Kumar, Jadhav, Vishalkumar, Tandel, Harshali, Pal, Kavita, Bhattacharjee, Atanu, Chaturvedi, Pankaj, Mittra, Indraneel“…CONCLUSION: These results suggest that cfChPs released into TME from dying cancer cells are global instigators for cancer hallmarks and immune checkpoints in surviving cancer cells. …”
Publicado 2022
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10238por Zhao, Fangyuan, Barber, Christy J., Sammani, Saad, Wan, Li, Miller, Brian W., Furenlid, Lars R., Li, Zheng, Gotur, Deepa B., Barrios, Roberto, Woolfenden, James M., Martin, Diego R., Liu, Zhonglin“…METHODS: HA of 10 kDa molecular weight (HA10) was radiolabeled with (125)I and (99m)Tc respectively to produce [(125)I]I-HA10 and [(99m)Tc]Tc-HA10, followed by comparative studies on stability, in vivo biodistribution, and uptake at inflammatory skin sites in mice with 12-O-tetradecanoylphorbol-13-acetate (TPA)-inflamed ears. [(99m)Tc]Tc-HA10 was used for iQID in vivo dynamic imaging of mice with ARDS induced by intratracheal instillation of LPS. RESULTS: [(99m)Tc]Tc-HA10 and [(125)I]I-HA10 had similar biodistribution and localization at inflammatory sites. [(99m)Tc]Tc-HA10 was shown to be feasible in measuring skin injury and monitoring skin wound healing. [(99m)Tc]Tc-HA10 dynamic pulmonary images yielded good visualization of radioactive uptake in the lungs. …”
Publicado 2022
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10239por Gao, Junling, Lei, Tong, Wang, Hongyun, Luo, Kai, Wang, Yuanli, Cui, Bingqing, Yu, Zhuoran, Hu, Xiaoqi, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing“…Mice were also acutely exposed to 10 mg/kg PM(2.5) and/or exogenous ADMA (2 mg/kg) via intratracheal instillation every other day for 2 weeks. Inflammatory response, oxidative stress and related gene expressions in the lungs were examined. …”
Publicado 2022
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10240por Kim, Soojung, Willis, Erin, Wehlage, Shane, Scheffer-Wentz, Hannah, Dulitz, Michael“…CONCLUSIONS: Short-term and long-term intentions were predicted differently. Instilling strong confidence in COVID-19 vaccines should increase both short-term and long-term intentions.…”
Publicado 2022
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