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  1. 10381
    “…CONCLUSIONS: After completing one or both MOOCs, self-reported confidence in genomic variant interpretation significantly increased, and most respondents could correctly classify variants such that appropriate clinical management would be instigated. Genomics HCPs reported higher satisfaction with the level of content than the non-genomics clinicians. …”
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    Evaluation of two Massive Open Online Courses (MOOCs) in genomic variant interpretation for the NHS workforce
  2. 10382
    “…BACKGROUND: Aging military veterans are an important and growing population who are at an elevated risk for developing mild cognitive impairment (MCI) and Alzheimer dementia, which emerge insidiously and progress gradually. Traditional clinic-based assessments are administered infrequently, making these visits less ideal to capture the earliest signals of cognitive and daily functioning decline in older adults. …”
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    Feasibility of In-Home Sensor Monitoring to Detect Mild Cognitive Impairment in Aging Military Veterans: Prospective Observational Study
  3. 10383
    “…BACKGROUND: We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. …”
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    Contribution of nuclear BCL10 expression to tumor progression and poor prognosis of advanced and/or metastatic pancreatic ductal adenocarcinoma by activating NF-κB-related signaling
  4. 10384
    “…Early recognition of seizures and aggressive instigation of treatment may help circumvent or slow neuronal loss and abate increasing disease burden. …”
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    Forecasting stroke-like episodes and outcomes in mitochondrial disease
  5. 10385
    “…It usually develops insidiously without any specific symptoms in the early stages. …”
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    Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis
  6. 10386
    “…Background: Optimal glycemic control of Type 1 Diabetes Mellitus (T1DM) remains a clinical challenge instigated by hypoglycemic episodes and the burden of insulin self-management. …”
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    SAT094 Closed-Loop Insulin Delivery Versus Standard Care In Type 1 Diabetic Adult Patients: A Meta-analysis Of Randomized Controlled Trials
  7. 10387
    “…Furthermore, we predicted 34 potential compounds, including cyclosporine, oestrogen and so on, which may engage with hub genes and attenuate immune disorders instigated by PTE. The diagnostic performance of these biomarkers, alongside the interventional effect of cyclosporine, was further corroborated in animal studies via ELISA, Western blot and immunofluorescence assays. …”
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    Demystifying the impact of prenatal tobacco exposure on the placental immune microenvironment: Avoiding the tragedy of mending the fold after death
  8. 10388
    “…The short-term adverse effects are observed within months of exposure such as pericardial diseases; meanwhile, the long-term complications are usually insidious and manifest over decades, such as congestive heart failure, coronary artery disease, cardiomyopathy, conduction disorders, constrictive pericarditis, and valvular heart disease. …”
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    Cardiovascular Outcomes Associated With Exposure To Radiation Therapy In Thoracic Malignancies: An Insight Study Using the National Inpatient Database
  9. 10389
    “…Reimbursement was adequate for both the medication and instillation protocols. CONCLUSION: Early experience with RBL administration found more treatment by GI than ID physician practices. …”
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    685. Early Experience with a Simple Administration of a Novel Fecal Microbiome Replacement for Prevention of Recurrent Clostridioides difficile
  10. 10390
    por Olitsky, Peter K.
    Publicado 1939
    “…Thus far, in limited experiments, feeding, or instilling nasally, or injecting into the vitreous body the infective agent has been ineffective. …”
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    EXPERIMENTAL STUDIES OF THE VIRUS OF INFECTIOUS AVIAN ENCEPHALOMYELITIS
  11. 10391
    “…Following intrarectal instillation of 20 median rectal infectious doses (MID(50)) of a noncloned, virulent stock of SIV(mac251/32H), all animals were analysed for virus infection, by virus isolation from peripheral blood mononuclear cells (PBMC), quantitative proviral DNA load in PBMC, plasma viral RNA (vRNA) load by sensitive quantitative competitive (qc) RT-PCR, and presence of SIV-specific serum antibodies by ELISA. …”
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    Prevention of SIV Rectal Transmission and Priming of T Cell Responses in Macaques after Local Pre-exposure Application of Tenofovir Gel
  12. 10392
    “…However, while reducing DUP will improve outcomes for most patients, there are some for whom prolonged DUP is a byproduct of an insidiously illness rather than a modifiable prognostic factor. …”
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    F136. PARSING DUP TO REFINE EARLY DETECTION: QUANTILE REGRESSION OF RESULTS FROM THE SCANDINAVIAN TIPS STUDY
  13. 10393
    “…Mice in LPS and LPS + CUR group were injected with saline or CUR (50 mg/kg) intraperitoneally 2 h before intratracheal instillation with LPS (100 μg/ml) for 7 days. Cell lysate and lung tissue were obtained to measured Mucin 5AC (MUC5AC) and Nrf2 mRNA and protein expression by a real-time polymerase chain reaction and Western blotting. …”
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    Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2
  14. 10394
    por Yein, Khin, Price, Elizabeth
    Publicado 2020
    “…Her presentation was insidious and there were no constitutional symptoms. …”
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    EP33 Sjögren’s and lymphoproliferative disorders
  15. 10395
    “…Hydatid bone infection progresses insidiously and frequently recurs, depending upon excision and debridement. …”
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    317. Case Series of Echinococcus Infections at Mayo Clinic Florida
  16. 10396
    “…For the IOP-lowering activity study, a single SA-2 NPs (1%) eye drop was instilled in normotensive rats eyes and in the IOP-elevated rat eyes (n = 3/group, in the Morrison model of glaucoma), or Ad5TGFβ2-induced ocular hypertensive (OHT) mouse eyes (n = 5/group). …”
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    Nanoencapsulated hybrid compound SA-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
  17. 10397
    “…Congestive hepatopathy, an abnormal state of the liver as a result of congestion, insidiously proceed toward end-stage liver disease without effective biomarkers evaluating pathological progression. …”
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    Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances
  18. 10398
    “…Due to limited amounts, the test item (0.3 mg per rat lung) was intratracheally instilled into the lungs. This dose avoided a particle overload effect, meaning that the toxicokinetic fate of carbon black could be followed under the approximated physiological conditions of lung clearance. …”
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    Toxicokinetics of Nanoparticles Deposited in Lungs Using Occupational Exposure Scenarios
  19. 10399
    “…BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Given its insidious onset, the condition often already progresses to advanced stage when symptoms occur. …”
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    Fecal gene detection based on next generation sequencing for colorectal cancer diagnosis
  20. 10400
    “…However, excessive downstream complement activation that leads to generation of C5a, and C5a engagement with its receptor C5aR1, instigates a feed-forward loop of inflammation, injury, and neuronal death, making C5aR1 a potential therapeutic target for neuroinflammatory disorders. …”
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    Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
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