“…We illustrated three quiescent risk factors for our patients, in addition to undiagnosed DM, prior statin use, and comorbidity with coronary artery disease (CAD) and thyroid disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The patients had type 2 diabetes with a history of non-Q-myocardial infarction receiving oral antidiabetic therapy and basic therapy, including an ACE inhibitor, a β-blocker, a statin, and an antiplatelet agent. Analysis of the investigated parameters in the leading group after receiving alpha-lipoic acid for 4 months showed a significant decrease in the concentration of C-Reactive Protein, IL-6 and TNF-α. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the frequency of dual positive γH2AX & p16 nuclei in adipose tissue of OSA patients receiving statin, aspirin, and/or RAS inhibitors was comparable to non-OSA individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This approach could potentially explore developing novel drugs from natural compounds (i.e. polyphenols, folic acid) and repurposing current drugs, such as statins and metformin. Several clinical trials have exploited epigenetic tags and epigenetic sensitive drugs both in primary and secondary prevention. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interestingly, our findings in statin-effect along with cholesterol synthesis pathway, especially isoprenoid dependency, revealed that this pathway is necessary and sufficient for the regulation of malignant architecture in SREBP2-dependent manner with cooperatively being controlled by mutant p53 on 3D-cultured breast cancer. …”
Enlace del recurso
Enlace del recurso

“…Current pharmacological modulators of inflammation, including corticosteroids and statins, have not been successful in improving outcomes during influenza virus infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Even though the lack of statically significant differences in most of the muscular oxygenation variables failed to refine the definite pathogenic mechanisms underlying nonspecific neck pain, the findings of modulatory strategies of faster deoxygenation implied that near-infrared spectroscopy appears to have practical potential to provide relevant physiological information regarding muscular oxidative metabolism and constituted convincing preliminary evidences of the adaptive manipulations rather than pathological responses of oxidative metabolism capacity of sternocleidomastoid muscles in nonspecific neck patients with mild disability.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A crucial issue in the evaluation of the benefit of the anti-inflammatory activity is the frequent discordance between a beneficial activity on a major risk factor and associated changes of hsCRP, as in the case of statins vs PCSK9 antagonists. In hypertension, angiotensin converting enzyme inhibitors exert an optimal anti-inflammatory activity, vs the case of sartans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Using data from a large trial of statin therapy for secondary prevention, we generated a set of simulated trial datasets under the null hypothesis (H0) and a set under an alternative hypothesis (H1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A typestate is a state machine specifying a Java object protocol, namely the permitted sequence of method calls of that object. Mungo statically typechecks that method calls follow the object’s protocol, as defined by its typestate specification. …”
Enlace del recurso
Enlace del recurso

“…As part of personalised care in T2DM, we routinely prescribe statins, angiotensin converting enzyme inhibitors and metformin, often with poor compliance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Accumulating evidence indicates that statins reduce the risk of different cancers and inhibit the proliferation of liver cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Connor–Davidson Resilience Scale, the Trait Meta-mood Scale, and Kessler Psychological Distress Scale were also administered. Statically significant differences are shown between the three examined groups: physical inactivity and non-beneficial physical activity; physical inactivity and beneficial physical activity, and; non-beneficial physical activity and beneficial physical activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Concomitant steroid or diuretics use increased IPV only in Advagraf-treated KTRs, whereas proton-pump inhibitor or statin use increased IPV in the Prograf group but not in the Advagraf group. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One of the pathways to reduce cholesterol production in the liver is through the inhibition of HMG-Coa reductase (HMGCR) by current drugs, statins. However, these have side effects if consumed in prolonged periods. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Statins are used to prevent and treat atherosclerotic cardiovascular disease, but they also induce myopathy and mitochondrial dysfunction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…During follow up, all patients were on stable antidiabetic and statin therapy. Liver stiffness was measured by FibroScan® (Echosens™ North America, Waltham, MA) elastography at baseline and at the six-month follow-up. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Aspirin and other non-steroidal anti-inflammatory drugs have moderate quality observational and randomized-trial evidence for preventing progression of BE to EAC, but their risks for harm have precluded their routine clinical use. Other therapies (statins, metformin, female sex hormones) generally do not have strong evidence to support their use in EAC chemoprevention. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Statin treatment reduces cardiovascular risk. However, individuals with well-controlled low-density lipoprotein (LDL) levels may remain at increased risk owing to persistent high triglycerides and low high-density lipoprotein cholesterol. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These findings provide a mechanistic explanation for the increased breast cancer risk associated with high dietary cholesterol and possibly the pro-survival effect of statins in breast cancer patients, highlighting the clinical relevance of lowering cholesterol levels in breast cancer patients overexpressing ERRα.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso