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  1. 37381
    “…Immune activation has been implicated in the excess mortality in human immunodeficiency virus (HIV)-infected patients, due to cardiovascular diseases and malignancies. Statins may modulate this immune activation. We assessed the capacity of rosuvastatin to mitigate immune activation in treatment-naive HIV-infected patients. …”
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    The Effect of Rosuvastatin on Markers of Immune Activation in Treatment-Naive Human Immunodeficiency Virus-Patients
  2. 37382
    “…In obese groups, BMI and urinary albumin were independent risk factors determining hs‐CRP levels, whereas triglyceride and statin were independent risk factors in non‐obese patients. …”
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    Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients
  3. 37383
    “…CONCLUSION: Simva increased the antitumor activity of PTX carried in LDE but not of PTX commercial presentation, possibly because statins increase the expression of LDL receptors that internalize LDE-PTX.…”
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    Simvastatin increases the antineoplastic actions of paclitaxel carried in lipid nanoemulsions in melanoma-bearing mice
  4. 37384
    “…Incident liver dysfunction in the following six months was identified by biochemical value and compared between statin groups by Cox regression model adjusting for age, sex, year treatment started, dose, alcohol consumption, smoking, body mass index and comorbid conditions. …”
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    High Dose Atorvastatin Associated with Increased Risk of Significant Hepatotoxicity in Comparison to Simvastatin in UK GPRD Cohort
  5. 37385
    por Abouzeid, Sameh, Mosbah, Osama
    Publicado 2016
    “…RESULTS: There was a significant increase in serum creatinine and a decrease in eGFR 48 hr post-intervention in group 1 (short regimen) with no statically difference regarding those parameters group 2 (long regimen). …”
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    Evaluation of different sodium bicarbonate regimens for the prevention of contrast medium-induced nephropathy
  6. 37386
    “…Statins purportedly exert anti-tumoral effects on breast cancer. …”
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    Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
  7. 37387
    “…Drug coverage was: 88.0% antiplatelet drugs, 86.5% statins, 75.6% β-blockers and 65.8% blockers of the renin-angiotensin system. …”
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    Risk factors and therapeutic coverage at 6 years in patients with previous myocardial infarction: the CASTUO study
  8. 37388
    “…AIMS: The objective of this study was to evaluate the efficacy, safety, and tolerability of LY3015014 (LY), a neutralizing antibody of proprotein convertase subtilisin/kexin type 9 (PCSK9), administered every 4 or 8 weeks in patients with primary hypercholesterolaemia, when added to a background of standard-of-care lipid-lowering therapy, including statins. METHODS AND RESULTS: Double-blind, placebo-controlled trial randomized 527 patients with primary hypercholesterolaemia from June 2013 to January 2014 at 61 community and academic centres in North America, Europe, and Japan. …”
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    Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study
  9. 37389
    “…Those with atheroma progression at follow-up were less likely to be on statin therapy (79 vs 100 %, p = 0.04), and had significantly higher baseline SAS (17.6 ± 11.2 vs 10.7 ± 5.1, p = 0.043). …”
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    Follow-up of atheroma burden with sequential whole body contrast enhanced MR angiography: a feasibility study
  10. 37390
    “…Lipitor(®), available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effectiveness of generic atorvastatin products and Lipitor(®). …”
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    Comparative Effectiveness of Generic Atorvastatin and Lipitor(®) in Patients Hospitalized with an Acute Coronary Syndrome
  11. 37391
    por Bauters, Christophe, Lemesle, Gilles
    Publicado 2016
    “…There was no evidence for an effect of screening on the use of statins (OR = 1.19 [0.94–1.51]), aspirin (OR = 1.02 [0.83–1.25]), or angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (OR = 0.97 [0.79–1.19]). …”
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    Screening for asymptomatic coronary artery disease in patients with diabetes mellitus: A systematic review and meta-analysis of randomized trials
  12. 37392
    por Toth, Peter P
    Publicado 2016
    “…Although low-density lipoprotein cholesterol (LDL-C) remains the primary treatment target to reduce CVD risk, a number of large-scale epidemiological studies have shown that elevated TG levels are independently associated with increased incidence of cardiovascular events, even in patients treated effectively with statins. Genetic studies have further clarified the causal association between TRLs and CVD. …”
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    Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease
  13. 37393
    “…We found weak evidence that higher LDL and TG levels increase aggressive prostate cancer risk, and that a variant in HMGCR (that mimics the LDL lowering effect of statin drugs) reduces risk. However, inferences are limited by sample size and evidence of pleiotropy.…”
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    Blood lipids and prostate cancer: a Mendelian randomization analysis
  14. 37394
    “…BACKGROUND AND AIMS: Although the beneficial effects of statins on stroke have been widely demonstrated both in experimental studies and in clinical trials, the aim of this study is to prepare and characterize a new liposomal delivery system that encapsulates simvastatin to improve its delivery into the brain. …”
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    Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats
  15. 37395
    “…RESULTS: There was a statically significant correlation between mental disorder and child abuse score (Spearman rho: 0.2; P-value < 0.001). …”
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    Child Abuse and Mental Disorders in Iranian Adolescents
  16. 37396
    por Zagorski, John, Kline, Jeffrey A.
    Publicado 2016
    “…In humans, inhibition of cholesterol synthesis with statins decreases biomarkers of inflammation. We test the differential effect of pulmonary vascular occlusion during mild and severe pulmonary embolism on the lung transcriptome. …”
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    Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome
  17. 37397
    “…In agreement with these findings, inactivation of the CBC increased tolerance to different classes of drugs targeting ergosterol biosynthesis including the azoles, allylamines (terbinafine) and statins (simvastatin). We reveal that a clinically relevant mutation in HapE (P88L) significantly impairs the binding affinity of the CBC to its target site. …”
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    Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex
  18. 37398
    “…All three formulations are well tolerated (the most common adverse events are gastrointestinal) and demonstrate a lack of drug-drug interactions with other lipid-lowering drugs, such as statins and fibrates. OM3FAs appear to be an effective treatment option for patients with severe hypertriglyceridemia.…”
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    The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
  19. 37399
    “…BACKGROUND: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. …”
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    The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients
  20. 37400
    “…There is controversy in the literature over the preventive effect of statins on CIN. OBJECTIVES: This study was designed to evaluate the preventive effect of atorvastatin on CIN after angiography in CKD and diabetic patients. …”
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    Preventive Effect of Atorvastatin (80 mg) on Contrast-Induced Nephropathy After Angiography in High-Risk Patients: Double-Blind Randomized Clinical Trial
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