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  1. 37641
    por Seidah, Nabil G., Garçon, Damien
    Publicado 2022
    “…Accordingly, inhibitors of PCSK9, including monoclonal antibodies blocking its circulating activity and siRNA silencers of its hepatic expression, are now used in clinics worldwide to treat hypercholesterolemia patients effectively and safely in combination with statins and/or ezetimibe. These powerful treatments reduce the incidence of atherosclerosis by at least 20%. …”
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    Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
  2. 37642
    “…The participants’ electronic health record data (FH-related diagnoses, lipid-lowering treatment prescriptions) and pharmacogenomic risk of developing statin-induced myopathy were assessed. A survey was administered to recalled participants to discern the impact of the knowledge of their genetic findings on their lives 4–6 years later. …”
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    Do Biobank Recall Studies Matter? Long-Term Follow-Up of Research Participants With Familial Hypercholesterolemia
  3. 37643
    “…Furthermore, CT-first patients were more likely to receive cardiovascular preventative and antianginal medication (aspirin: 44.9% vs 27.1%, statins: 48.7% vs 30.3%, beta-blockers: 37.8% vs 25.5%, in CT-first and without CT-first patients, respectively) and to undergo downstream diagnostics and interventions (coronary interventions: 8.5% vs 5.7%, coronary angiography: 16.2% vs 10.6% in CT-first and without CT-first patients, respectively). …”
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    Outcomes in patients with a first episode of chest pain undergoing early coronary CT imaging
  4. 37644
    “…There were also indications that cholesterol levels may have prognostic indications and that statins may have therapeutic benefits.…”
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    A Review of COVID-19 in Relation to Metabolic Syndrome: Obesity, Hypertension, Diabetes, and Dyslipidemia
  5. 37645
    “…It is well known that statins are more effective in reducing blood lipid concentrations than ezetimibe, however, our results that ezetimibe had a better anti-inflammatory effect than rosuvastatin in AS. …”
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    Ezetimibe ameliorates clinical symptoms in a mouse model of ankylosing spondylitis associated with suppression of Th17 differentiation
  6. 37646
    “…METHODS: Consecutive statin-naive individuals at intermediate cardiovascular risk referred for coronary artery calcium score (CACS) scanning were included. …”
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    Association between Lipoprotein Subfractions, Hemostatic Potentials, and Coronary Atherosclerosis
  7. 37647
    “…We quantified in full-length HCN2 channels the resulting functional effects of the inserted glycines by current activation as well as the structural dynamics and statics using molecular dynamics simulations and Constraint Network Analysis. …”
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    Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts
  8. 37648
    “…Only exercising was statically significant in reducing PHQ-9 scores. None of the studied factors were significant in reducing GAD-7 scores. …”
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    The Impact of Anxiety and Depression on Academic Performance: A Cross-Sectional Study among Medical Students in Syria
  9. 37649
    “…The association between the risk of malnutrition and functional capacity was analysed using bivariate and multivariate logistic regression adjustments for gender, age, ankle-brachial index, body mass index, use of statins, coronary arterial disease and stroke. For all statistical analyses, significance was accepted at p<0.05. …”
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    Association between the risk of malnutrition and functional capacity in patients with peripheral arterial disease: A cross-sectional study
  10. 37650
    “…INTRODUCTION: Low-dose aspirin or clopidogrel, statins, renin–angiotensin system inhibitors, and beta blockers are the cornerstone therapy for cardiovascular prevention in patients with coronary heart disease. …”
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    Comparison of Aspirin and Rivaroxaban Plus Aspirin in the Management of Stable Coronary Artery Disease or Peripheral Artery Disease: A Systematic Review of Randomized Controlled Trials
  11. 37651
    “…RESULTS: CLC was not linked to overall plaque presence or burden after adjustments for atherosclerotic cardiovascular disease (ASCVD) score, statin use and low-density lipoprotein cholesterol. …”
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    Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis
  12. 37652
    “…Data were entered in SPSS version 20 and both descriptive and analytic statics analysis were performed. RESULT: A total of 157 elective patients undergoing elective cesarean section were included with response rate of 96.9%. …”
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    Maternal satisfaction and practice of preoperative anaesthesia evaluation among pregnant who underwent elective caesarean section, cross-sectional study
  13. 37653
    “…Among the pharmacological interventions, gabapentin was the most effective [MD 8.95 (95% CI 1.95–15.85)], which also improved sleep quality [standardized MD 2.00 (95% CI 0.47–3.53)]. No statically significant adverse events were detected. …”
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    Pharmacological and non-pharmacological treatments for restless legs syndrome in end-stage kidney disease: a systematic review and component network meta-analysis
  14. 37654
    “…Specifically, current smokers, and those with diabetes had significantly more inappropriate use of aspirin and statins for primary prevention than non-smokers and patients without diabetes. …”
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    Retrospective Study of Appropriate Primary Prevention in Postmenopausal Women Presenting with a Major Adverse Cardiovascular Endpoint (MACE)
  15. 37655
    “…BACKGROUND AND AIMS: The American Diabetes Association recommends statin therapy for young type 2 diabetes mellitus (T2DM) adults only if one additional cardiovascular (CV) risk factor coexists. …”
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    High Prevalence of Additional Cardiovascular Risk Factors in Eastern-Indian Young Adults with Type 2 Diabetes Mellitus
  16. 37656
    “…These effects were not seen in patients taking angiotensin converting enzyme inhibitors (ACEIs) or statins. ARB use while undergoing SBRT for early stage lung cancer may increase OS and RFS, but ACEI use does not show the same effect.…”
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    Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer
  17. 37657
    “…RESULTS: This study found no statically significant differences between the control and intervention groups at both pre‐ and post‐intervention. …”
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    Effectiveness of sensory modulation for people with schizophrenia: A multisite quantitative prospective cohort study
  18. 37658
    “…[Image: see text] Understanding the interactions between drugs and lipid membranes is a prerequisite for finding the optimal way to deliver drugs into cells. Coadministration of statins and anticancer agents has been reported to have a positive effect on anticancer therapy. …”
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    Simvastatin Coadministration Modulates the Electrostatically Driven Incorporation of Doxorubicin into Model Lipid and Cell Membranes
  19. 37659
    “…The obtained K ( i,u,OATP) for CP‐I was 5.0‐ and 2.8‐fold lower than that obtained for statins, confirming our previous findings describing substrate‐dependent K ( i,u,OATP) values. …”
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    Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies
  20. 37660
    “…At baseline, 61% of participants were using renin–angiotensin system blockers, 55% were taking statins and 49% were taking oral iron. Baseline demographics were similar to those in other large non-dialysis anaemia trials. …”
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    The ASCEND-ND trial: study design and participant characteristics
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