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37781“…Account 2 expressed views on the potential overuse of statin medication and placed responsibility for lifestyle change with the patient. …”
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37782por Holtfreter, Birte, Empen, Klaus, Gläser, Sven, Lorbeer, Roberto, Völzke, Henry, Ewert, Ralf, Kocher, Thomas, Dörr, Marcus“…Restrictions to subjects without antihypertensive or statin medication or current non-smokers confirmed previous results. …”
Publicado 2013
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37783por Wändell, Per, Carlsson, Axel C, Sundquist, Jan, Johansson, Sven-Erik, Bottai, Matteo, Sundquist, Kristina“…RESULTS: Overall mortality was lower in the whole sample for anticoagulants vs no treatment (HR 0.45; 95% CI 0.26-0.77); and among patients < 80 years for anticoagulants vs. antiplatelets (HR 0.44; 95% CI 0.25-0.78); while among individuals aged ≥80 years, antiplatelets (HR 0.47; 95% CI 0.26-0.87) and anticoagulants (HR 0.49; 95% CI 0.24-1.00) vs. no treatment were equally effective. Statins were associated with lower mortality among those <80 years (HR 0.45; 95% CI 0.29-0.71). …”
Publicado 2014
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37784por Kung, Kenny, Chow, Kai Ming, Hui, Eric Ming-Tung, Leung, Maria, Leung, Shuk Yun, Szeto, Cheuk Chun, Lam, Augustine, Li, Philip Kam-Tao“…Over half (51.5%) had an HbA1c level of less than 7.0%. 88.4% did not achieve target lipid level. 15% were on diet control alone. Only 22.2% were on statins. In patients with microalbuminuria and macroalbuminuria, 40.7% and 54.5% were on angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) respectively. 12.9%, 38.8% and 2.4% had diabetic retinopathy, nephropathy and neuropathy respectively. …”
Publicado 2014
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37785“…BACKGROUND: An emerging data suggested a significant impact of statins on PCSK9 concentration, while the rapid impacts of other lipid-lowering drugs such as ezetimibe and xuezhikang alone or in combination on PCSK9 and lipid profile have not been assessed. …”
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37786“…The prevalence of OA in postmenopausal females was slightly higher than males (χ(2) = 3.86, P = 0.052), with no statically significant difference. The risks of OA obviously increased with age. …”
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37787por Akinloye, Oluyemi, Blessing Popoola, Bolutife, Bolanle Ajadi, Mary, Gregory Uchechukwu, Joseph, Pius Oparinde, Dolapo“…Data obtained were statically analyzed with the SPSS 15.0 software, and results were expressed as mean ± SEM. …”
Publicado 2014
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37788por Ghobadi, Hassan, Lari, Shahrzad M., Pourfarzi, Farhad, Mahmoudpour, Afsoun, Ghanei, Mostafa“…BACKGROUND: Statins have anti-inflammatory effects in patients with chronic obstructive pulmonary disease (COPD). …”
Publicado 2014
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37789por Bengtsson, Erik, Nerjovaj, Pashtrik, Wangefjord, Sakarias, Nodin, Björn, Eberhard, Jakob, Uhlén, Mathias, Borgquist, Signe, Jirström, Karin“…The utility of HMGCR as a predictor of response to neoadjuvant or adjuvant statin treatment in colorectal cancer merits further study. …”
Publicado 2014
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37790por Del Ben, Maria, Polimeni, Licia, Carnevale, Roberto, Bartimoccia, Simona, Nocella, Cristina, Baratta, Francesco, Loffredo, Lorenzo, Pignatelli, Pasquale, Violi, Francesco, Angelico, Francesco“…Same findings were also observed after the exclusion of obese subjects, or subjects with diabetes or with metabolic syndrome and in those not taking statin medication. In addition, the levels of urinary 8-iso-PGF2α were independent predictors of non-alcoholic fatty liver and a strong association of urinary 8-iso-PGF2α and of serum soluble NOX2-derived peptide with the severity of steatosis at ultrasound was also observed. …”
Publicado 2014
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37791por Buhse, Susanne, Heller, Tabitha, Kasper, Jürgen, Mühlhauser, Ingrid, Müller, Ulrich Alfons, Lehmann, Thomas, Lenz, Matthias“…Treatment goals refer to statin taking, HbA1c-, blood pressure levels and smoking status. …”
Publicado 2013
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37792por Gajendragadkar, Parag R., Hubsch, Annette, Mäki-Petäjä, Kaisa M., Serg, Martin, Wilkinson, Ian B., Cheriyan, Joseph“…METHODS AND RESULTS: We randomised 36 statin treated CVD patients and 36 healthy volunteers in a 2∶1 treatment allocation ratio to either 7 mg lycopene or placebo daily for 2 months in a double-blind trial. …”
Publicado 2014
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37793por Du, Ruixue, Cai, Jianming, Zhao, Xue-Qiao, Wang, Qing-Jun, Liu, Dan-Qing, Leng, Wen-Xiu, Gao, Peng, Wu, Hong-Mei, Ma, Lin, Ye, Ping“…BACKGROUND: Statin therapy has shown to deplete atherosclerotic plaque lipid content and induce plaque regression. …”
Publicado 2014
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37794“…Furthermore, there was a low rate of referral for carotid ultrasound in patients with anterior circulation strokes. Anti-platelets and statins were commenced for most patients with ischaemic stroke while diabetes was well controlled in most of them. …”
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37795“…For primary prevention, statins are recommended if the ten-year risk is ≥ 5% (consideration for therapy) or ≥ 7.5% (definitive treatment unless contraindication after discussion). …”
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37796por Cuchel, Marina, Bruckert, Eric, Ginsberg, Henry N., Raal, Frederick J., Santos, Raul D., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Descamps, Olivier S., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, Wiklund, Olov, Chapman, M. John, Cuchel, Marina, Bruckert, Eric, Chapman, M. John, Descamps, Olivier S., Ginsberg, Henry N., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Raal, Frederick J., Santos, Raul D., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Chapman, M. John, Ginsberg, Henry N., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, Wiklund, Olov“…Lifestyle intervention and maximal statin therapy are the mainstays of treatment, ideally started in the first year of life or at an initial diagnosis, often with ezetimibe and other lipid-modifying therapy. …”
Publicado 2014
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37797“…Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer's disease, but the exact mechanisms of action are still unknown. …”
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37798“…Non-standard therapies include the use of corticosteroids and statins; however, these therapies lack conclusive supporting evidence(4). …”
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37799por van Staa, Tjeerd-Pieter, Gulliford, Martin, Ng, Edmond S.-W., Goldacre, Ben, Smeeth, Liam“…METHODS AND FINDINGS: This study included 1.8 million persons without CVD and prior statin prescribing using the Clinical Practice Research Datalink. …”
Publicado 2014
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37800por Brænne, Ingrid, Reiz, Benedikt, Medack, Anja, Kleinecke, Mariana, Fischer, Marcus, Tuna, Salih, Hengstenberg, Christian, Deloukas, Panos, Erdmann, Jeanette, Schunkert, Heribert“…Sequencing of all family members available for genetic analysis revealed co-segregation of the variant with CAD (LOD 3.0) and increased LDLC (>190 mg/dL), following correction for statin treatment (LOD 4.3). Interestingly, mutation carriers presented with highly variable corrected (183–354 mg/dL) and on-treatment LDL levels (116–274 mg/dL) such that the diagnosis of FH in this family was made only after the molecular-genetic analysis. …”
Publicado 2014
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