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  1. 38341
    “…Serum homocysteine levels were significantly higher in patients with CMED, and the highest quartile of serum homocysteine level (>9 µmol/L) was an independent predictor of CMED (odds ratio, 1.34 [95% CI, 1.03–1.75]; P=0.03) after adjustment for age; sex; body mass index; chronic kidney disease (CKD); diabetes mellitus; smoking exposure; low‐density lipoprotein cholesterol; high‐density lipoprotein cholesterol and triglycerides; and aspirin, statin, and B vitamin use. CONCLUSIONS: Patients with CMED have significantly higher levels of serum homocysteine. …”
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    Coronary Microvascular Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Artery Disease Is Associated With Elevated Serum Homocysteine Levels
  2. 38342
    “…RESULTS: The following variables were significantly and independently associated with actively working at the last contact: age>median (hazard-ratio [HR], 0.76, p<0.001); male sex (HR, 1.52, p<0.001); government health insurance (HR, 1.36, p<0.001); history of angina (HR, 0.69, p<0.001) or myocardial infarction (MI) (HR, 0.76, p=0.005); smoking (HR, 0.81, p=0.015); ST-elevation MI (HR, 0.81, p=0.021); anterior-wall MI (HR, 0.75, p=0.001); non-primary percutaneous coronary intervention (PCI) (HR, 0.77, p=0.002); fibrinolysis (HR, 0.61, p<0.001); cardiogenic shock (HR, 0.60, p=0.023); statin (HR, 3.01, p<0.001), beta-blocker (HR, 1.26, p=0.020), angiotensin-converting enzyme (ACE) inhibitor/angiotensin II receptor blocker (ARB) (HR, 1.37, p=0.001) at hospital discharge; and MI at follow-up (HR, 0.72, p=0.001). …”
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    Factors associated with actively working in the very long-term following acute coronary syndrome
  3. 38343
    “…After adjustment for age, BMI, diabetes, and statin medication, only adiponectin [hazard ratio (HR) 1.18 (1.10–1.26, P = 4.1E‐08)], pyruvate [HR 1.38 (1.28–1.50, P = 8.2E‐05)], and UAER [HR 1.15 (1.11—1.18, P = 7.8E‐06)] remained statistically significant. …”
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    Novel biomarkers associated with incident heart failure in 10 106 Finnish men
  4. 38344
    “…Results: Some of the relevant results: (1) first description of FIRES as a new epilepsy syndrome and its further investigation, (2) in SCN2A, the assignment to gain- vs. loss-of-function mutations has a major impact on clinical decisions to use or avoid treatment with sodium channel blockers, (3) the important aspect of avoiding overtreatment in CDKL5 patients, due to loss of effects of anticonvulsants after 12 months, (4) pathognomonic MRI findings in FOXG1 patients, (5) the first description of pathognomonic chewing-induced seizures in SYNGAP1 patients, and the therapeutic effect of statins as anticonvulsant in these patients, (6) the phenomenon of another reflex epilepsy—bathing epilepsy associated with a SYN1 mutation. …”
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    Network for Therapy in Rare Epilepsies (NETRE): Lessons From the Past 15 Years
  5. 38345
    “…Women remained less likely to receive aspirin, beta-blocker, angiotensin-converting enzyme inhibitor (ACE-I) and statin. Women were less likely to undergo angiography and percutaneous coronary intervention (PCI) despite an overall increase. …”
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    Sex and gender differences in presentation, treatment and outcomes in acute coronary syndrome, a 10 year study from a multi-ethnic Asian population: The Malaysian National Cardiovascular Disease Database—Acute Coronary Syndrome (NCVD-ACS) registry
  6. 38346
    por Wargny, Matthieu, Potier, Louis, Gourdy, Pierre, Pichelin, Matthieu, Amadou, Coralie, Benhamou, Pierre-Yves, Bonnet, Jean-Baptiste, Bordier, Lyse, Bourron, Olivier, Chaumeil, Claude, Chevalier, Nicolas, Darmon, Patrice, Delenne, Blandine, Demarsy, Delphine, Dumas, Marie, Dupuy, Olivier, Flaus-Furmaniuk, Anna, Gautier, Jean-François, Guedj, Anne-Marie, Jeandidier, Nathalie, Larger, Etienne, Le Berre, Jean-Philippe, Lungo, Myriam, Montanier, Nathanaëlle, Moulin, Philippe, Plat, Françoise, Rigalleau, Vincent, Robert, René, Seret-Bégué, Dominique, Sérusclat, Pierre, Smati, Sarra, Thébaut, Jean-François, Tramunt, Blandine, Vatier, Camille, Velayoudom, Fritz-Line, Vergès, Bruno, Winiszewski, Patrice, Zabulon, Audrey, Gourraud, Pierre-Antoine, Roussel, Ronan, Cariou, Bertrand, Hadjadj, Samy
    Publicado 2021
    “…Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. CONCLUSIONS/INTERPRETATION: In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. …”
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    Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study
  7. 38347
    “…Benzodiazepine derivatives were associated with an increased risk of brain cancer (adjusted odds ratio [AOR] 1.379, 95% CI 1.138-1.670; P=.001). Statins were associated with a reduced risk of liver cancer (AOR 0.470, 95% CI 0.426-0.517; P<.0001) and gastric cancer (AOR 0.781, 95% CI 0.678-0.900; P<.001). …”
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    Development of a Web-Based System for Exploring Cancer Risk With Long-term Use of Drugs: Logistic Regression Approach
  8. 38348
    “…RESULTS: Most of the metabolic parameters and radiomics features are statically stable through the 2D and 3D modes. Most of the 3D mode features show a correlation with metabolic parameters; the total lesion glycolysis (TLG) shows the highest correlation, with a Spearman correlation coefficient (rs) of 0.9776. …”
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    Advanced intra-tumoural structural characterisation of hepatocellular carcinoma utilising FDG-PET/CT: a comparative study of radiomics and metabolic features in 3D and 2D
  9. 38349
    “…Isosorbide mononitrate and nicorandil were stopped for adverse effects in 36 of 172 (20.9%) and 32 of 141 (22.7%) of patients, respectively. Statins were well tolerated and taken by 191 of 200 (95.5%) patients. …”
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    Achieving Optimal Medical Therapy: Insights From the ORBITA Trial
  10. 38350
    “…METHODS: We performed a single-center retrospective study of the associations between ATBs and other drugs known to modify the gut microbiota (proton pump inhibitors, nonsteroidal anti-inflammatory drugs, statins, opioids, anti-vitamin K, levothyroxine, vitamin D3, antiarrhythmics, metformin and phloroglucinol), overall survival (OS) and tumor response in consecutive cancer patients (particularly those with melanoma) treated with an ICI (ipilimumab, nivolumab or pembrolizumab) over a 9-year period. …”
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    Associations between dysbiosis-inducing drugs, overall survival and tumor response in patients treated with immune checkpoint inhibitors
  11. 38351
    “…Frequencies, proportion, and summary statics were used to describe the study population. …”
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    Assessments of Birth Outcome of Twin Delivery and Associated Factors among Newborns in Dessie Referral Hospital, Dessie, Ethiopia, 2019
  12. 38352
    por Kogut, Stephen J
    Publicado 2020
    “…Many health disparities involve medications, including antidepressants, anticoagulants, diabetes medications, drugs for dementia, and statins, to name a few. Managed care pharmacy has a role in perpetuating racial disparities in medication use. …”
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    Racial disparities in medication use: imperatives for managed care pharmacy
  13. 38353
    “…Logistic regression analysis demonstrated that modulation of these inflammatory variables was independent of age, smoking, and statin treatment. Furthermore, our in vitro functional data linked IL-32 to macrophage activation and production of IL-18 and downregulation of TRAIL, a mechanism previously shown to be associated with impaired cholesterol metabolism and atherosclerosis. …”
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    Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis
  14. 38354
    “…Statins can cause muscle symptoms resulting in poor adherence to therapy and increased cardiovascular risk. …”
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    Robust Performance of Potentially Functional SNPs in Machine Learning Models for the Prediction of Atorvastatin-Induced Myalgia
  15. 38355
    “…Stepwise logistic regression analysis and multivariate Cox proportional hazard regression analysis identified shorter REM‐SL as an independent risk factor for the development of a new‐onset CVD events, independent of mean oxygen saturation, log (AHI+1), log (central AHI+1), diabetes mellitus, CVD history, systolic blood pressure, statins use, and non‐HDL‐C. CONCLUSIONS: The present study demonstrated that reduction of REM‐SL is independently associated with a higher rate of new‐onset of CVD events, independent of SRBDs (OSA and CSA) and diabetes mellitus, non‐HDL‐C in HD study participants, suggesting impaired SQ as a potential CVD risk factor, and thus a definite treatment target to protect against CVD specifically in HD study participants. …”
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    REM sleep latency as an independent risk for cardiovascular events in hemodialysis patients
  16. 38356
    “…Blood pressure control significantly improved in the intervention clinics (OR 3.556, 95 % CI 2.219, 5.696) but not the control clinics (OR 0.644, 95 % CI 0.370, 1.121) (p < 0.001 for interaction). Smoking assessment, statin prescribing, triple therapy prescribing, and blood pressure measurement significantly improved in intervention clinics relative to control, whereas cholesterol and glucose testing, and aspirin prescribing did not. …”
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    Evaluation and pilot implementation of essential interventions for the management of hypertension and prevention of cardiovascular diseases in primary health care in the Republic of Tajikistan
  17. 38357
    “…Angiotensin receptor blocker (ARBs) and statins were the most commonly prescribed concomitant drugs. …”
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    Pattern of Disease and Therapy for Diabetes along with Impact of Generic Prescribing on Cost of Treatment among Outpatients at a Tertiary Care Facility
  18. 38358
    “…METHODS AND RESULTS: Electronic databases were searched through January 2020 to identify randomized controlled trials of treatments targeting upregulation of LDL‐C receptors (ie, statins, ezetimibe, and PCSK9 [proprotein convertase subtilisin–kexin type 9] inhibitors). …”
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    Meta‐Analysis of Intensive Lipid‐Lowering Therapy in Patients With Polyvascular Disease
  19. 38359
    “…Despite high utilization of evidence-based treatments including coronary revascularization, intensive statin treatment, and dual antiplatelet therapy, the 3-year incidence of MACE in the placebo group was elevated among insulin-treated patients (20.4%) compared to those not-treated with insulin (12.8%, P = 0.0001). …”
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    Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial
  20. 38360
    “…The second objective was to seek a statically significant cut-off value for NLR and PLR that could suggest COVID-19. …”
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    Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients
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