Mostrando 41 - 60 Resultados de 39,310 Para Buscar 'Jtatik~', tiempo de consulta: 2.02s Limitar resultados
  1. 41
    “…The use or misuse of statins in critically ill patients recently attracted the attention of intensive care clinicians. …”
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    “…Heart disease (HD) is the number one killer in the United States.(1) In 2006, the direct and indirect costs associated with cardiovascular disease in the United States were estimated at 400 billion dollars.(2) Statin therapy for cholesterol reduction is a mainstay intervention for cardiovascular disease (CVD) as reflected in atorvastatin's status as the number one prescribed medication in the United States.(3) Statin therapy, however, is also associated with side effects that signal mitochondrial distress. …”
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  4. 44
    por Raju, Soma B., Varghese, Kiron, Madhu, K.
    Publicado 2013
    “…Statins are the revolutionary drugs in the cardiovascular pharmacotherapy. …”
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  5. 45
    “…These multiple lipid-independent effects of statins termed as statin pleiotropy would potentially open floodgates for research in multiple treatment domains catching attentions of researchers and clinician across the globe.…”
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    por Blake, Gavin J, Ridker, Paul M
    Publicado 2000
    “…Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. …”
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    por Mohebi, Reza, Rosenson, Robert
    Publicado 2019
    “…In this review, we discuss clinical evidence-based data regarding the potential benefit of statin therapy in the perioperative period of non-cardiac surgery. …”
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    “…The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvastatin and pravastatin) present greater hepatoselectivity. …”
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  17. 57
    “…Elevated low-density lipoprotein-cholesterol (LDL-C) is a causal factor for the development of atherosclerotic cardiovascular disease (ASCVD); accordingly, LDL-C lowering is associated with a decreased risk of progression of atherosclerotic plaques and development of complications. Currently, statins play a central role in any ASCVD management and prevention strategies, in relation to their lipid-lowering action and potentially to pleiotropic effects. …”
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    “…Together with therapeutic lifestyle changes, statins are the most common lipid-lowering drugs. …”
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