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  1. 1781
    “…The mevalonate pathway is essential in eukaryotes and responsible for a diversity of fundamental synthetic activities. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the rate-limiting enzyme in the pathway and is targeted by the ubiquitous statin drugs to treat hypercholesterolemia. Independent reports have indicated the cidal effects of statins against the flatworm parasite, S. mansoni, and the possibility that SmHMGR is a useful drug target to develop new statin-based anti-schistosome therapies. …”
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    Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis
  2. 1782
    “…Atorvastatin was the safest statin as it resulted in the least number of patients with microalbuminuria (10.92%) as compared to other statins. …”
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    Comparison of efficacy, safety, and cost-effectiveness of various statins in dyslipidemic diabetic patients
  3. 1783
    por Li, X, Wu, X B, Chen, Q
    Publicado 2014
    “…BACKGROUND: There is contradictory evidence about the association between statin and skin cancer. METHODS: Literature search in PubMed and Web of Science was undertaken up to June 2013. …”
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    Statin use is not associated with reduced risk of skin cancer: a meta-analysis
  4. 1784
    “…According to multiple regression analysis for variables predicting static balance, the linear combination of trunk muscle endurance measures was significantly related to the static balance (F (3,46) = 66.60, P<0.001). …”
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    Evaluation of Relationship between Trunk Muscle Endurance and Static Balance in Male Students
  5. 1785
    “…They underwent serial static posturography assessments and the dizziness handicap inventory (DHI) to investigate whether PR dalfampridine could impact standing balance and self-reported perception of balance. …”
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    Oral Dalfampridine Improves Standing Balance Detected at Static Posturography in Multiple Sclerosis
  6. 1786
    “…This effect can be ameliorated by repression, suggesting that while HGT is not necessarily advantageous for a population in a static environment, its deleterious effect on the mean fitness can be negated via repression. …”
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    Repression/Depression of Conjugative Plasmids and Their Influence on the Mutation-Selection Balance in Static Environments
  7. 1787
    “…In this paper, we present a comparative analysis of the most important methods used in the literature for the registration of subsequent RGB-D video frames in static scenarios. The analysis begins by explaining the characteristics of the registration problem, dividing it into two representative applications: scene modeling and object reconstruction. …”
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    A Comparative Study of Registration Methods for RGB-D Video of Static Scenes
  8. 1788
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    A meta-analysis of randomized controlled trials on the use of statins in septic patients
  9. 1789
    “…BACKGROUND: Statins can modify bile cholesterol and, thus, the formation of gallstones. …”
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    Effect of statin use on outcome of symptomatic cholelithiasis: a case-control study
  10. 1790
    por Oliveira, R, Schettino, G, Park, M, Azevedo, L
    Publicado 2006
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    Influence of ventilatory settings on the value of static hemodynamic variables and pulse pressure variation
  11. 1791
    “…The sliding of a solid object on a solid substrate requires a shear force that is larger than the maximum static friction force. It is commonly believed that the maximum static friction force is proportional to the loading force and does not depend on the apparent contact area. …”
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    Novel Friction Law for the Static Friction Force based on Local Precursor Slipping
  12. 1792
    “…Wind loads coefficients have been measured through static wind tunnel tests and the Den Hartog criterion applied to elucidate the influence of geometrical parameters on the galloping properties of the bodies under consideration. …”
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    Static and Dynamic Experimental Analysis of the Galloping Stability of Porous H-Section Beams
  13. 1793
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    Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
  14. 1794
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    Evaluation of lung recovery after static administration of three different perfluorocarbons in pigs
  15. 1795
    “…The risk of myopathy and rhabdomyolysis is considerably increased in statin users with end-stage renal failure (ESRF). …”
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    Uremic Toxins Enhance Statin-Induced Cytotoxicity in Differentiated Human Rhabdomyosarcoma Cells
  16. 1796
    “…Experimental studies suggested that statins attenuate vascular AT(1) receptor responsiveness. …”
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    Statin Treatment in Hypercholesterolemic Men Does Not Attenuate Angiotensin II-Induced Venoconstriction
  17. 1797
    “…This paper intends to study how the cracks at central or rail-seat section in prestressed concrete sleepers influence the track behaviour under static loading. The track model considers three different sleeper models: uncracked, cracked at central section, and cracked at rail-seat section. …”
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    Analysis of the Influence of Cracked Sleepers under Static Loading on Ballasted Railway Tracks
  18. 1798
    “…First, patients receiving statin therapy have relatively low levels of medication adherence compared with other drug classes. …”
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    Statin Pharmacogenomics: Opportunities to Improve Patient Outcomes and Healthcare Costs with Genetic Testing
  19. 1799
    “…We emphasize that although the high specificity is well known to promote temporal “Red Queen” diversity, it is costs and combinations of hosts and parasites that cannot infect that will promote static trait diversity.…”
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    HOW SPECIFICITY AND EPIDEMIOLOGY DRIVE THE COEVOLUTION OF STATIC TRAIT DIVERSITY IN HOSTS AND PARASITES
  20. 1800
    “…BACKGROUND: Statins are an important intervention for primary and secondary cardiovascular disease (CVD) prevention. …”
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    Variations in statin prescribing for primary cardiovascular disease prevention: cross-sectional analysis
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