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  1. 14181
    por Georgiades, Kalliopi, Raoult, Didier
    Publicado 2011
    “…In this study, we investigated if protein toxins are indeed the only molecules specific to pathogenic bacteria by comparing 14 epidemic bacterial killers (“bad bugs”) with their 14 closest non-epidemic relatives (“controls”). …”
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    Comparative Genomics Evidence That Only Protein Toxins are Tagging Bad Bugs
  2. 14182
    “…Seventy-three percent were taking pain killers with an average improvement on their pain score of 52%. …”
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    Anatomy of the Pain Centre waiting list at the Centre hospitalier de l’Université de Montréal (CHUM)
  3. 14183
    “…The participants were addicted to either alcohol (2), benzodiazepines (1), pain killers (1) or polydrug-use (5). The sponsors were unpaid, and had no history of addiction problems. …”
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    Practical support aids addiction recovery: the positive identity model of change
  4. 14184
    “…BACKGROUND: Malaria remains one of the greatest public health challenges worldwide and it is amongst the top killers in sub-Saharan Africa. There is however, a general scepticism about the accuracy of Health Management Information Systems (HMIS) in recording all the episodes of malaria in Africa. …”
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    Knowledge and practices towards malaria amongst residents of Bushbuckridge, Mpumalanga, South Africa
  5. 14185
    “…Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally infected and cancerous targets by polarized release from secretory lysosomes. …”
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    Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis
  6. 14186
    “…Studies of the link between environmental pollutants and cardiovascular dysfunction, neglected for decades, have recently provided new insights into the pathology and consequences of these killers. In this study, rats were divided into four groups, each containing 10 rats. …”
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    Mitigation of diazinon-induced cardiovascular and renal dysfunction by gallic acid
  7. 14187
    “…The latter is among the big killers and frequently gives rise to brain metastases, most often discovered at diagnosis. …”
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    Brain Metastases from Lung Cancer: Is MET an Actionable Target?
  8. 14188
    por Kavanagh, Matthew M., Chen, Lixue
    Publicado 2019
    “…BACKGROUND: The Global Fund to Fight AIDS, Tuberculosis and Malaria has proven highly effective at fighting the world’s major killers. Strong governance and robust development institutions are necessary, however, for improving health long-term. …”
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    Governance and Health Aid from the Global Fund: Effects Beyond Fighting Disease
  9. 14189
    “…Cardiovascular diseases (CVDs) are silent killers and hyperlipidemia is a high-risk factor. …”
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    Catechin profile and hypolipidemic activity of Morinda citrifolia leaf water extract
  10. 14190
    “…Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers. The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR). …”
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    Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice
  11. 14191
    “…Different pathways are triggered leading to genetic and epigenetic modulation with consequent reprogramming of immune cells such as T-cells (effector, memory or regulatory), tumor-associated macrophages (TAMs) (M1 or M2), natural killers (NK) cells (active or senescent), and dendritic cells (DC) (effector or tolerogenic), etc. …”
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    Metabolic Factors Affecting Tumor Immunogenicity: What Is Happening at the Cellular Level?
  12. 14192
    “…Although neutrophils are well-known professional killers, some pathogens including Leishmania (L.) parasites survive in neutrophils, using these cells to establish infection. …”
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    The c-MET receptor tyrosine kinase contributes to neutrophil-driven pathology in cutaneous leishmaniasis
  13. 14193
    “…We previously showed that a Plasmodium-derived peptide conjugated to a rearranged form of α-galactosylceramide (α-GalCer) could stimulate liver-resident memory T (T(RM)) cells that were effective killers of liver-stage Plasmodium berghei ANKA (Pba)-infected cells. …”
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    6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria
  14. 14194
    “…Cardiovascular diseases (CVDs) are the world's leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. …”
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    Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review
  15. 14195
    “…Voltage-gated sodium (Na(v)) channel Na(v)1.7 has been targeted for the development of nonaddictive pain killers. Structures of Na(v)1.7 in distinct functional states will offer an advanced mechanistic understanding and aid drug discovery. …”
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    Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7
  16. 14196
    “…Tuberculosis (TB) is one of the world's deadliest infectious disease killers today, and despite China's increasing efforts to prevent and control TB, the TB epidemic is still very serious. …”
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    Predicting the Number of Reported Pulmonary Tuberculosis in Guiyang, China, Based on Time Series Analysis Techniques
  17. 14197
    “…The comminatory therapy can serve as a first-in-class and most effective oral medication for aortic aneurysms, which can be rapidly translated into clinical practice to revolutionize management of the devastating vascular diseases of aortic aneurysms known as silent killers.…”
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    Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication
  18. 14198
    “…BACKGROUND: We aimed to evaluate the outcomes of resections for liver metastases (LMs) originating from pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), and esophagus/gastric cancers (EGCs), which we label as major killers (MKs; overall survival (OS) under 10%). We hypothesized that LM resection must provide the patient with almost a year of OS postoperatively that is considered beneficial. …”
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    Will Patients With Liver Metastasis From Aggressives Cancers Benefit From Surgical Resection?
  19. 14199
    “…Through conditional cooccurrence models, we found that Andean tiger cat habitat use was invariant to the presence of prey or potential intraguild competitors and killers/predators, but its detectability increased when they were present and detected. …”
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    Assessing microhabitat, landscape features and intraguild relationships in the occupancy of the enigmatic and threatened Andean tiger cat (Leopardus tigrinus pardinoides) in the cloud forests of northwestern Colombia
  20. 14200
    por Slavin, Shimon
    Publicado 2023
    “…Supported by pre-clinical experiments in animal models, we hypothesized that immunotherapy induced by non-engrafting intentionally mismatched IL-2 activated killers (IMAK) including both T & NK cells could induce safer, faster and much more effective immunotherapy while avoiding the need for SCT and the risks of GVHD. …”
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    Immunotherapy with cure potential of multi-drug resistant hematologic malignancies using IL-2 preactivated intentionally mismatched donor lymphocyte
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