“…Chlorambucil enhanced αPDL1 efficacy in tumors otherwise αPDL1-refractory, and improved antitumor immunity and treatment efficacy in a natural killer cell-dependent manner alone and plus αPDL1. …”
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“…Based on single-cell RNA-seq data, we found elevated hexokinase 1 (HK1) and glucose-6-phosphate isomerase (GPI) gene expression in natural killer (NK) and CD8(+) T cells. RT-PCR in ten CRC normal-tumor tissue pairs showed that expression of the signature’s six HRGs varied differently in cancerous and paracancerous tissues. …”
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“…SIMPLE SUMMARY: Lung cancer is the biggest killer among cancers. Its mortality is related to delayed diagnosis which is often achieved in the advanced stages of the disease when surgery is no longer an option. …”
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“…Natural killer (NK) cell-based adoptive immunotherapy in leukemia patients is an emerging field of interest based on clinical evidence of efficacy and safety. …”
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“…Immunohistochemistry for B7‐H3 (CD276, Cluster of Differentiation 276), CD47 (Cluster of Differentiation 47), PD‐L1 (programmed cell death ligand 1), TIM3 (mucin‐domain containing‐3), TGF‐β (TransformingGrowth Factor β), CXCR 4 (Chemokine Receptor 4), CD27 (Cluster of Differentiation 27), IDO1 (Indoleamine 2,3‐dioxygenase 1), KIRs (Killer cell Immunoglobulin‐like Receptors), and SDF‐1 (Stromal cell‐Derived Factor‐1) was performed on 35 resected osteosarcoma specimens. …”
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“…There was no significant difference in the percentage and absolute counts of natural killer (NK) cells and B lymphocytes among the four groups. …”
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“…The abnormal cells seen in three patients in complete remission were Fcγ receptor IIIB (FcγRIIIB) gene deletion (CD16- neutrophils), CD2-CD159a(-)CD159c(+) natural killer (NK) cells, and monoclonal B lymphocytosis (MBL), respectively. …”
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“…Discoveries: The 3 neutrinos Theory: Why and how do the neutrinos oscillate? The killer question: What is a particle without mass? …”
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“…We report an increase in mean absolute counts of WBC (seven studies; standardised mean difference [SMD] = 1.07; 95% CI, 0.61–1.53; P < 0.01; I(2) = 64%), granulocytes (two studies; SMD = 2.07; 95% CI, 1.45–2.68; P < 0.01; I(2) = 0%), neutrophils (four studies; SMD = 0.91; 95% CI, 0.23–1.58; P < 0.01; I(2) = 82%), monocytes (seven studies; SMD = 0.60; 95% CI, 0.19–1.01; P < 0.01; I(2) = 66%), CD4(+) helper T cells (11 studies; SMD = 0.30; 95% CI, 0.15–0.45; P < 0.01; I(2) = 0%), natural killer cells (11 studies; SMD = 1.23; 95% CI, 0.38–2.08; P < 0.01; I(2) = 95%), B cells (10 studies; SMD = 0.30; 95% CI, 0.03–0.57; P = 0.03; I(2) = 56%), and activated T cells (eight studies; SMD = 0.45; 95% CI, 0.24–0.66; P < 0.01; I(2) = 0%) in depression, compared to controls. …”
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“…BACKGROUND: Diabetes is one of the leading killers among noncommunicable diseases of the present time and poses a considerable burden to the society in terms of public health. …”
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“…At the single-cell level, we also found that the increase of endothelial cells and the decrease of cytotoxic T/natural killer (NK) cells led to a worse prognosis for pN2-B patients compared to pN2-A patients. …”
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“…Inhibition of antigen-stimulated T cells by CD45RA+ PBMCs could be reproduced only by the naïve T-cell fraction, while CD45RA+ regulatory T cells, natural killer cells, stem cell memory and effector memory subsets lacked inhibitory activity. …”
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“…METHODS: In the present study, we aimed to explore changes in peripheral T regulatory (Treg) and circulating natural killer (NK) cell frequency, circulating NK cell subset distribution and function, during treatment. …”
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“…We also evaluate the count of leukocytes and their subsets, T lymphocytes (CD4(+), CD8(+)), natural killer (NK) cells, and T regulatory cells. METHODS: A total of 45 patients suffering from AD were examined: 32 patients without dupilumab treatment (10 men, 22 women, average age 35 years), 13 patients with dupilumab treatment (7 men, 6 women, average age 43.4 years), and 30 subjects as a control group (10 men, 20 women, average age 44.7 years). …”
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“…A comparison of the cardiovascular complication incidence between three waves revealed that the incidence of hemorrhage (48 vs. 24 vs. 17%), myocardial necrosis (18 vs. 11 vs. 4%), blood clots in the intramural arteries (12 vs. 7 vs. 0%), and myocarditis (19 vs. 1 vs. 6%) decreased over time, and CD8-T-killers appeared. Immunohistochemistry confirmed the presence of endotheliitis in all 21 studied cases. …”
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“…RESULT: A total of 10 cell types were identified, namely, monocytes, macrophages, CD4 T/NK (CD4+ T cells and natural killer T cells), mast cells, B/Plasma B cells, fibroblasts, endothelial cells, cytotoxic T cells (CD8+ T cells, CTLs), vascular smooth muscle cells (vSMCs), and mature dendritic cells (mDCs). …”
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“…BACKGROUND: Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-related tumours by regulating cancer growth and tumour elimination proved in previous literature. …”
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“…Flow cytometry showed significantly increased levels of CD4(+) T cells, CD4(+)CD8(+) T cells, and CD4(+)CD25(+)CD127(−) Tregs and significantly decreased the levels of CD16(+)CD56(+) natural killer cells on day 5 after cRFA (p < 0.05). Transcriptomics and proteomics revealed 389 DEGs and 20 DEPs. …”
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“…Last year, TB was the second leading infectious killer after SARS-CoV-2. Nevertheless, many biological and immunological aspects of TB are not completely elucidated, such as the complex process of immunoregulation mediated by regulatory T cells (Treg cells) and the enzymes indoleamine 2,3-dioxygenase (IDO) and heme oxygenase 1 (HO-1). …”
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“…Subsequently, we investigated the impact of natural killer (NK) cell activation after rIL-2 starvation followed by exposure to the sIL-15/IL-15Rα complex. …”
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