“…INTRODUCTION: Pancreatic cancer is the 10(th)most common malignancy and the 4(th)largest cancer killer in adults. AIM: The purpose of this paper is to evaluate the number of cases presented with pancreatic carcinoma during the years 2011-2015, our experience of the imaging characteristics of pancreatic carcinoma. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CD14(+) monocytes, CD4(+) and CD8(+) T lymphocytes (CD3(+)), CD80(+), C-X-C chemokine receptor 3 (CXCR3)(+) and CD27(+) B lymphocytes (CD19(+)), CD16(+)CD56(+)CD3(−) natural killer (NK) cells and activated CD56(+)CD3(+) T cells, for association with arthritis development in patients with arthralgia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, other non-HLA genes may also influence the immune process, such as the genes encoding the immunoglobulin-like receptors of natural killer cells (KIRs). The discovery that NK cell KIR receptors interact with conservative epitopes (C1, C2, Bw4) presented in HLA class I molecules that are genetically polymorphic, also observed in KIR genes, led to the investigation of the relevance of the KIR system to hematopoietic stem cell transplant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Increasing experimental and clinical evidence highlight the importance of natural killer (NK) cells in immune responses toward multiple myeloma (MM), and combination therapies able to enhance the activity of NK cells against MM are showing promise in treating this hematologic cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 10 smokers and 10 nonsmokers we used RRBS to fine map differential methylation in CD4+ T cells, CD8+ T cells, CD14+, CD15+, CD19+, and CD56+ natural killer cells. Distinct cell-type differences in smoking-associated methylation and gene expression were identified. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND AND AIM: Natural Killer (NK) cells are involved in the control of viral infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have utilized primary human peripheral blood and hepatic mononuclear cells, mouse MAIT hybridoma lines, HLA-DR4-transgenic mice, MAIT(high)HLA-DR4(+) bone marrow chimeras, and humanized NOD-scid IL-2Rγ(null) mice to demonstrate for the first time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by staphylococcal enterotoxin B (SEB); ii) the human MAIT cell response to SEB is rapid and far greater in magnitude than that launched by unfractionated conventional T, invariant natural killer T (iNKT) or γδ T cells, and is characterized by production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-2, but not IL-17A; iii) high-affinity MHC class II interaction with SAgs, but not MHC-related protein 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occur in a T cell receptor (TCR) Vβ–specific manner but are largely contributed by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develop a molecular signature consistent with exhaustion and failure to participate in antimicrobial defense. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then these cells were subjected to analyze the CD11c expression pattern on natural killer (NK) cells and T cells. RESULTS: This assay showed that after MCMV infection, the expression of CD86 on pulmonary CD11c(hi)MHC-II(hi) cells (encompassing conventional DCs) was higher at 3 days post-infection than at 1 or 7 days post-infection, accompanied by a downregulation of MHC II. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The viable cell percentage of T lymphocyte subsets (CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+)) and natural killer (NK) cells were measured by flow cytometry. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Numerous empirical studies have described the phenomenon after various traumas, including traumatic bereavement, even among children and adolescents (Kilmer et al., 2009). Objective: The qualitative study presented was conducted in the UK, where eight women were interviewed after losing their first child perinatally. …”
Enlace del recurso
Enlace del recurso

“…Natural killer (NK) cells are part of the innate immune system and recognize virus-infected cells as well as tumor cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interestingly, these pathways were related to the typical functions of leukocytes cells, such as antigen processing and presentation and natural killer cell mediated cytotoxicity. We also applied this method to obtain the absolute gene expression threshold in already published microarray data of liver cells, where the top 5% expressed genes showed an enrichment of typical KEGG pathways for liver cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Higher HLA-C levels may lead to better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes and the triggering of activating killer immunoglobulin-like receptors on NK cells, whereas lower levels may provide poor HIV-1 control and rapid progression to AIDS. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells (mDCs; CD1c and CD40), mature inactive myeloid cells (CD1c and HLA), active plasmacytoid cells (pDCs; CD303 and CD40), mature inactive pDCs (CD30 and HLA), active natural killer (NK) cells (CD56 and CD161), active NK cells (CD56 and CD314) and inactive NK cells (CD56 and CD158) was done by flow cytometry. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although CD161(high) CD8(+) T cells were mostly T cell receptor-Vα7.2(+) mucosal-associated invariant T cells, CD161 expressing CD4(+) and CD8(+) T cells showed a limited expression of markers for gamma–delta T cells or invariant natural killer (NK) T cells, in both young and old subjects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Seven days after IAV infection, there were reduced infiltration of natural killer cells and CD8(+) T lymphocytes, increased concentration of inflammatory cytokines in bronchoalveolar fluid, reduced numbers of resolving macrophages, and IL-10 levels in PI3Kγ KO. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The levels of: immunoglobulins IgG, IgA, IgM, total lymphocytes, lymphocytes subpopulations CD3+, CD4+, CD8+, CD19+, natural killer cells, Treg cells (CD4+ CD25+ CD127− FOXP3+), anti-inflammatory cytokines (interleukin-10, transforming growth factor-β), anti-nuclear antibodies, glutamic acid decarboxylase (GAD65 Abs), anti-thyroid peroxidase (anti-TPO Ab), and anti-thyroglobulin (anti-TG Ab) autoantibodies were determined in each participant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, we determined that natural killer group 2, member D (NKG2D) on γδTc and the NKG2D ligand MHC class I polypeptide-related sequence A (MICA)/B on MCF-7 and T47D breast cancer cell lines are important for γδTc cytotoxicity, but that MIP1α, RANTES, and CD40L do not play a direct role in cytotoxicity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso