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341“…Incident CVD occurred in 13,426 (15.3%) people, including 6,013 atrial fibrillation, 7,727 heart failure, and 2,809 acute myocardial infarction events. …”
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342por Cheetham, Nathan J., Penfold, Rose, Giunchiglia, Valentina, Bowyer, Vicky, Sudre, Carole H., Canas, Liane S., Deng, Jie, Murray, Benjamin, Kerfoot, Eric, Antonelli, Michela, Rjoob, Khaled, Molteni, Erika, Österdahl, Marc F., Harvey, Nicholas R., Trender, William R., Malim, Michael H., Doores, Katie J., Hellyer, Peter J., Modat, Marc, Hammers, Alexander, Ourselin, Sebastien, Duncan, Emma L., Hampshire, Adam, Steves, Claire J.“…METHODS: Cognitive performance (working memory, attention, reasoning, motor control) was assessed in a prospective cohort study of participants from the United Kingdom COVID Symptom Study Biobank between July 12, 2021 and August 27, 2021 (Round 1), and between April 28, 2022 and June 21, 2022 (Round 2). …”
Publicado 2023
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343por Emmert-Fees, Karl M. F., Amies-Cull, Ben, Wawro, Nina, Linseisen, Jakob, Staudigel, Matthias, Peters, Annette, Cobiac, Linda J., O’Flaherty, Martin, Scarborough, Peter, Kypridemos, Chris, Laxy, Michael“…We developed a microsimulation model (IMPACT(NCD) Germany) that captures the demographics, risk factor profile and epidemiology of type 2 diabetes, coronary heart disease (CHD) and stroke in the German population using the best available evidence and national data. …”
Publicado 2023
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344por Lee, Hocheol, Koh, Sang Baek, Jo, Heui Sug, Lee, Tae Ho, Nam, Hae Kweun, Zhao, Bo, Lim, Subeen, Lim, Joo Aeh, Lee, Ho Hee, Hwang, Yu Seong, Kim, Dong Hyun, Nam, Eun Woo“…The United Kingdom has implemented a strategy to address loneliness, including social prescribing—a health care model where physicians prescribe nonpharmacological interventions to tackle social loneliness. …”
Publicado 2023
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345“…The estimated 10-year CVD risk for both groups was calculated by the United Kingdom Prospective Diabetes Study (UKPDS) Risk Engine (version 2) based on age, sex, race, smoking status, atrial fibrillation, duration of diabetes, levels of A1c, systolic BP (SBP) and TC, and high-density lipoprotein cholesterol (HDL-C)observed at 12 months. …”
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346por Kivimäki, Mika, Walker, Keenan A, Pentti, Jaana, Nyberg, Solja T, Mars, Nina, Vahtera, Jussi, Suominen, Sakari B, Lallukka, Tea, Rahkonen, Ossi, Pietiläinen, Olli, Koskinen, Aki, Väänänen, Ari, Kalsi, Jatinderpal K, Goldberg, Marcel, Zins, Marie, Alfredsson, Lars, Westerholm, Peter J M, Knutsson, Anders, Theorell, Töres, Ervasti, Jenni, Oksanen, Tuula, Sipilä, Pyry N, Tabak, Adam G, Ferrie, Jane E, Williams, Stephen A, Livingston, Gill, Gottesman, Rebecca F, Singh-Manoux, Archana, Zetterberg, Henrik, Lindbohm, Joni V“…DESIGN: Multicohort study with three sets of analyses. SETTING: United Kingdom, Europe, and the United States. PARTICIPANTS: Three associations were examined: cognitive stimulation and dementia risk in 107 896 participants from seven population based prospective cohort studies from the IPD-Work consortium (individual participant data meta-analysis in working populations); cognitive stimulation and proteins in a random sample of 2261 participants from one cohort study; and proteins and dementia risk in 13 656 participants from two cohort studies. …”
Publicado 2021
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347por Brown, Li-An K., Freemantle, Nick, Breuer, Judy, Dehbi, Hakim-Moulay, Chowdhury, Kashfia, Jones, Gemma, Ikeji, Felicia, Ndoutoumou, Amalia, Santhirakumar, Krishneya, Longley, Nicky, Checkley, Anna M., Standing, Joseph F., Lowe, David M.“…Exploratory: Proportion of participants with deleterious or resistance-conferring mutations in SARS-CoV-2. RANDOMISATION: Participants will be randomised 1:1:1:1 using a concealed online minimisation process, with the following factors: trial site, age (≤ 55 vs > 55 years old), gender, obesity (BMI <30 vs ≥30), symptomatic or asymptomatic, current smoking status (Yes = current smoker, No = ex-smoker, never smoker), ethnicity (Caucasian, other) and presence or absence of comorbidity (defined as diabetes, hypertension, ischaemic heart disease (including previous myocardial infarction), other heart disease (arrhythmia and valvular heart disease), asthma, COPD, other chronic respiratory disease). …”
Publicado 2021
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348“…Peroxiredoxins (Prxs) exhibit 24 h rhythms in their redox state in all kingdoms of life. In mammalian adrenal gland, heart and brown adipose tissue, such rhythms are generated as a result of an inactivating hyperoxidation reaction that is reduced by coordinated import of sulfiredoxin (Srx) into the mitochondria. …”
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349por Ben-Zvi, Tamar, Pushkarev, Alina, Seri, Hemda, Elgrably-Weiss, Maya, Papenfort, Kai, Altuvia, Shoshy“…Putrescine belongs to the large group of polyamines, an essential class of metabolites that exists throughout all kingdoms of life. The Salmonella speF gene encodes an inducible ornithine decarboxylase that produces putrescine from ornithine. …”
Publicado 2019
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350“…We generated small RNA libraries across 5 mammalian species (cow, dog, horse, pig and rabbit) from 4 different tissues (brain, heart, kidney and testis). We identified 1676 miRBase and 413 novel miRNAs by manually curating the set of computational predictions obtained from miRCat and miRDeep2. …”
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