“…PP-13 induced a transient mitotic blockade by interfering with both mitotic spindle organization and microtubule dynamics and finally led to mitotic slippage, aneuploidy and direct apoptotic death. PP-13 was identified as a microtubule-targeting agent that binds directly to the colchicine site in β-tubulin. …”
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“…MicroDNAs are thought to arise from DNA breaks associated with RNA metabolism or replication slippage. Given the paucity of information on this entirely novel phenomenon, we aimed to get an additional insight into microDNA features by performing the microDNA analysis in 20 independent human lymphoblastoid cell lines (LCLs) prior and after treatment with chemotherapeutic drugs. …”
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“…An A and T bias was observed among the single base INDELs, in which most of these were induced by replication slippage at either the homopolymer or polynucleotide repeat regions. …”
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“…Examination of the deletion-flanking regions suggested microhomology-mediated end joining, replication slippage, and non-homologous end joining, respectively, as the most likely mechanisms for the 3 distinct deletions. …”
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“…Time-lapse microscopy illustrated both of these compounds caused mitotic delays in treated cells, resulting in either mitotic slippage or apoptosis. This finding along with immunostaining, in vitro polymerization assays, and animal experiments in both athymic and immunocompetent mice, demonstrates that these third-generation benzopyran compounds are potent tubulin polymerization inhibitors in vitro and in vivo, and this is the molecular basis of their anti-cancer activity in melanoma. …”
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“…The risk of early re-operation was similar between the groups. The slippage was corrected more accurately and reliably by D. …”
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“…Both the degree of crystallinity ([Formula: see text]) and the alpha star transition, associated with the slippage between crystallites, increase with the content of nanoparticles in the PVA selective layer. …”
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“…In the fatigue tests, material slippage was low, allowing for cyclic tests beyond 10(5) cycles. …”
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“…This subsequently promoted DNA strand slippage allowing pol β to skip over a template loop and causing TNR deletion. …”
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“…Recently, the large P1 of Sweet potato feathery mottle virus (SPFMV) was characterized finding an extra ORF produced after polymerase slippage, which originates the product P1N-PISPO. Transient expression assays showed that SPFMV P1 and P1N-PISPO presented RSS activity, while HCPro did not. …”
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“…Its use in fiber pre-processing enables the formation of a layer of film with weak acidity, which restrains the hydration of adjacent gel materials, and reduces the strength of transitional areas of the fiber/composite interface, which restricts fiber slippage and pulls out as a result of its growth in age, and reduces hydration levels. …”
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“…Deficient MMR (dMMR) results in a strong mutator phenotype known as microsatellite instability (MSI), characterized by widespread length polymorphisms of microsatellite sequences due to DNA polymerase slippage. MSI is recognized as one of the major carcinogenetic pathways of colorectal cancer (CRC): it represents a molecular hallmark of hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome (LS); moreover it is detected in 15% of sporadic colorectal cancers, more often due to an epigenetic inactivation of MLH1. …”
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“…Repeats include transposable elements that can self-mobilize and disperse around the genome and tandemly-repeated satellite DNAs that increase in copy number due to replication slippage and unequal crossing over. Despite their abundance, repetitive DNAs are often ignored in genomic studies due to technical challenges in identifying, assembling, and quantifying them. …”
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“…Here, we determine the most favorable mutual orientations of the trans-stars in the stack in terms of (i) the [Formula: see text] – [Formula: see text] distance between the cores lengthwise the aggregate, (ii) the lateral displacements due to slippage and (iii) the rotation promoting the helical twist and chirality of the aggregate. …”
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“…Lateral radiographs revealed L5/S1 dysplastic type spondylolisthesis with >75% slippage (Meyerding Grade IV), a dome-shaped sacrum, and a flat back with butterfly sign. …”
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“…Lastly, we determined a structure of a transcript initiation complex at the pyrBI promoter and proposed an alternative mechanism of RNA slippage and extension requiring the σ dissociation from the core enzyme.…”
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“…This recombination event was RecA-independent, which agreed with the replication slippage model. To increase plasmid stability, a reversed paired-gRNA plasmids (RPGPs) cloning strategy was developed by converting DRs to the more stable invert repeats (IRs), which completely eliminated DRs-induced recombination. …”
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“…Long pedicle screws are conducive to connecting the rod and reducing slippage.…”
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“…Elevated levels of crossing over and repeat expansions accompany these deletion events, indicating that many, if not most, of these events are associated with template switching in postreplication gaps as opposed to simple replication slippage. The deletion data underpin simulations indicating that multiple postreplication gaps may be generated per replication cycle. …”
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“…Moreover, the connection joints exhibited multiple failure modes, including the fracture of gusset plates, the slippage of high-strength bolts, the local buckling of compressive splice plates, the fracture of tensile splice plates and concrete cracking. …”
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