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1781“…P-gp could act as a lipid flippase and stimulate Gb3 induction when tumor cells are exposed to cancer chemotherapy. …”
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1782por Goren, Michael A., Morizumi, Takefumi, Menon, Indu, Joseph, Jeremiah S., Dittman, Jeremy S., Cherezov, Vadim, Stevens, Raymond C., Ernst, Oliver P., Menon, Anant K.“…Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process required for disc homeostasis. …”
Publicado 2014
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1783por Kaur, Hundeep, Lakatos-Karoly, Andrea, Vogel, Ramona, Nöll, Anne, Tampé, Robert, Glaubitz, Clemens“…Here we demonstrate by nucleotide turnover and binding studies based on (31)P solid-state NMR spectroscopy that the ABC exporter and lipid A flippase MsbA can couple ATP hydrolysis to an adenylate kinase activity, where ADP is converted into AMP and ATP. …”
Publicado 2016
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1784“…We therefore, therefore, developed Flip-Flop, a flippase-dependent in vivo cassette-inversion method that marks wild-type cells with the endogenous EGFP-tagged protein, whereas mutant cells are marked with mCherry upon inversion. …”
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1785por Bolla, Jani Reddy, Corey, Robin A., Sahin, Cagla, Gault, Joseph, Hummer, Alissa, Hopper, Jonathan T. S., Lane, David P., Drew, David, Allison, Timothy M., Stansfeld, Phillip J., Robinson, Carol V., Landreh, Michael“…Turning to the lipid flippase MurJ, we find that addition of the natural substrate lipid‐II results in the formation of a 1:1 protein–lipid complex, where the lipid cannot be displaced by detergent from the highly protected active site. …”
Publicado 2020
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1786Protein Adsorption on Solid Supported Membranes: Monitoring the Transport Activity of P-Type ATPasespor Tadini-Buoninsegni, Francesco“…In the present review, we discuss how the SSM method has contributed to investigate some key features of the transport mechanism of P-type ATPases, with a special focus on sarcoplasmic reticulum Ca(2+)-ATPase, mammalian Cu(+)-ATPases (ATP7A and ATP7B), and phospholipid flippase ATP8A2.…”
Publicado 2020
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1787por Ng, Eunice Sze Yin, Kady, Nermin, Hu, Jane, Dave, Arpita, Jiang, Zhichun, Pei, Jacqueline, Gorin, Michael B., Matynia, Anna, Radu, Roxana A.“…The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (RPE) cells. …”
Publicado 2022
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1788“…This technique prevents the slippage of the applied clips, was developed along the career of the senior author (Juha Hernesniemi), and has been previously proved to be safe and effective for aneurysm clipping. …”
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1789“…Frameshifting of prokaryotic ribosomes was pseudoknot-independent (although secondary structure dependent) and appeared to require slippage of only a single tRNA.…”
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1790“…We speculate that the possible mechanism of early complication of CAS could be slippage and shortening of the stent due to weak anchoring between the stent strut and the fibrotic arterial wall in radiation-induced carotid stenosis.…”
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1791“…A possible origin of such an error is incomplete correction of a tetraploid state resulting from failed cytokinesis or mitotic slippage during early embryonic development. CONCLUSION: This unique case suggests that embryonic cells may have a mechanism for tetraploidy correction that involves mitotic pairing of homologous chromosomes.…”
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1792por Curran, J F“…Frameshifting is more frequent at sites where the in-frame codon ends in uridine, as if third position wobble pairs to message uridine facilitate slippage into the +1 frame. Consistent with other studies of programmed frameshift sites, efficient frameshifting depends on stable message:tRNA base pairs after rephasing. …”
Publicado 1993
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1793“…The crystal packing is influenced by π-stacking interactions of the parallel displaced type [centroid–centroid distance of 3.723 (1) Å for molecule 1 and 3.884 (1) Å for molecule 2, with ring slippages of 1.432 and 1.613 Å, respectively] and the T-shaped type, with the long molecular axes all aligned along [010].…”
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1794“…The crystal structure also exhibits intermolecular C—Br⋯π [3.737 (3) Å] interactions, and weak π–π interactions between the benzene and furan rings of neighbouring molecules [centroid–centroid distance = 3.557 (3) Å, interplanar distance = 3.421 (3) Å and slippage = 0.974 (3) Å].…”
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1795por Yusof, Mohd Sukeri Mohd, Embong, Nur Farhana, Arshad, Suhana, Razak, Ibrahim Abdul“…Weak C—H⋯Cl, C—H⋯F, C—H⋯S and π–π [centroid–centroid separation = 3.7098 (6)Å and slippage = 1.853 Å] interactions also occur.…”
Publicado 2012
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1796“…This last bias could systematically inflate evolutionary rates inferred from molecular data because first fossil occurrences will not be recognised as such. Stem-ward slippage, whereby fundamental taphonomic biases cause fossils to be interpreted as erroneously primitive, is therefore a ubiquitous problem for all biologists attempting to infer macroevolutionary rates or sequences.…”
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1797“…In addition, the crystal structure also exhibits π–π interactions between the 4-chlorophenyl rings of adjacent molecules [centroid–centroid distance = 4.094 (3) Å, interplanar distance = 3.648 (3) Å and slippage = 1.656 (3) Å].…”
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1798por Wang, Pengbo, Lindsay, Jennefer, Owens, Thomas W., Mularczyk, Ewa J., Warwood, Stacey, Foster, Fiona, Streuli, Charles H., Brennan, Keith, Gilmore, Andrew P.“…Avoidance of this mechanism may explain the selective pressure for cancer cells to undergo mitotic slippage.…”
Publicado 2014
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1799“…Within the sheets there are weak parallel slipped π–π interactions involving inversion-related benzenesulfonamide rings [centroid–centroid distance = 3.8800 (9) Å; normal distance = 3.4796 (6) Å; slippage = 1.717 Å].…”
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1800por Wang, Huaping, Liu, Wanqiu, He, Jianping, Xing, Xiaoying, Cao, Dandan, Gao, Xipeng, Hao, Xiaowei, Cheng, Hongwei, Zhou, Zhi“…Health monitoring of pavements is becoming more and more significant, as frequently suffering from cracks, rutting, and slippage renders them prematurely out of service. Effective and reliable sensing elements are thus in high demand to make prognosis on the mechanical properties and occurrence of damage to pavements. …”
Publicado 2014
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