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  1. 1821
    por Fu, Benzhong, Yan, Qing
    Publicado 2023
    “…In this study, a deletion mutation of bceQ gene, encoding a putative flippase for the EPS biosynthesis, was introduced in the genome of PsJN. …”
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    Exopolysaccharide is required for motility, stress tolerance, and plant colonization by the endophytic bacterium Paraburkholderia phytofirmans PsJN
  2. 1822
    “…LpxT-catalysed phosphorylation is dependent upon transport of lipid A across the inner membrane by MsbA, a lipid A flippase, indicating a periplasmic active site. In conclusion, we demonstrate a novel pathway in the periplasmic modification of lipid A that is directly linked to the synthesis of undecaprenyl phosphate, an essential carrier lipid required for the synthesis of various bacterial polymers, such as peptidoglycan.…”
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    Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate
  3. 1823
    “…Three of the suppressor mutations defined an unexpected player, the P-type ATPase TAT-2, which belongs to the flippase family of proteins that are implicated in mediating phospholipid bilayer asymmetry. …”
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    P-Type ATPase TAT-2 Negatively Regulates Monomethyl Branched-Chain Fatty Acid Mediated Function in Post-Embryonic Growth and Development in C. elegans
  4. 1824
    “…The translocation (flipping) step of Lipid II was demonstrated to require a specific protein (flippase). Here, we show that the integral membrane protein FtsW, an essential protein of the bacterial division machinery, is a transporter of the lipid-linked peptidoglycan precursors across the cytoplasmic membrane. …”
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    Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane
  5. 1825
    “…Inactivation of genes predicted to be involved in various stages of EPS biosynthesis eliminated both the rugose colonial appearance and production of EPS, while knockout of a predicted flippase function involved in EPS transport resulted in a dry, lightly striated phenotype, which was associated with a reduction of brp-encoded EPS on the cell surface. …”
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    Genetic Analysis and Prevalence Studies of the brp Exopolysaccharide Locus of Vibrio vulnificus
  6. 1826
    “…Here, we describe a rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies (CIGMC), which uses the flippase from the yeast 2-μm plasmid. Using green fluorescence protein as a model, we verified that the fluorescent intensity was in accordance with the integration copy number of the target gene. …”
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    A rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies
  7. 1827
    “…P-type ATPases of subfamily IV (P4-ATPases) constitute a major group of phospholipid flippases that form heteromeric complexes with members of the Cdc50 (cell division control 50) protein family. …”
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    Role of post-translational modifications at the β-subunit ectodomain in complex association with a promiscuous plant P4-ATPase
  8. 1828
    “…We provide genetic and cellular evidence that AP-2 interacts with endocytic markers SlaB(End4) and SagA(End3) and the lipid flippases DnfA and DnfB in the sub-apical collar region of hyphae. …”
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    The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi
  9. 1829
    “…To disambiguate orexin-dependent and -independent physiological functions of orexin neurons, we generated a novel Orexin-flippase (Flp) knock-in mouse line. Crossing with Flp-reporter or Cre-expressing mice showed gene expression exclusively in orexin neurons. …”
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    Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice
  10. 1830
    “…Lastly, we showed that the expression of a flippase that can transport unfinished precursors resulted in an increased susceptibility to bacitracin and mild cell shape defects, which may be a driving force to maintain transporter specificity.…”
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    High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae
  11. 1831
    “…Similarly, novobiocin transport performed in the presence of verapamil and a docking analysis highlighted protein MsbA (Lipid A flippase, gene PA4997) as a potential candidate in novobiocin efflux. …”
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    Effects of Verapamil and Two Bisbenzylisoquinolines, Curine and Guattegaumerine Extracted from Isolona hexaloba, on the Inhibition of ABC Transporters from Pseudomonas aeruginosa
  12. 1832
    “…The computational analysis indicates two possible major targets for this class of compounds, namely lipoteichoic acids flippase (LtaA) and lipoprotein signal peptidase II (LspA). …”
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    Antimicrobial Activity of Rhenium Di- and Tricarbonyl Diimine Complexes: Insights on Membrane-Bound S. aureus Protein Binding
  13. 1833
    “…This complex is composed of an atypical GC fused to a flippase-like P4-ATPase domain and assembled with the cell division control protein CDC50.1 and a unique GC organizer (UGO). …”
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    A Signaling Factor Linked to Toxoplasma gondii Guanylate Cyclase Complex Controls Invasion and Egress during Acute and Chronic Infection
  14. 1834
    “…ATP8B1 is a phospholipid flippase that is deficient in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1). …”
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    ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells
  15. 1835
    “…This could reduce early graft failure due to slippage of the third free femoral graft strand.…”
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    Biomechanical Investigation of Different Preparation Techniques of Tripled Soft Tissue ACL Grafts
  16. 1836
    “…However, only decompression may progress the slippage which can result in pain or recurrence of neurological complaints. …”
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    Surgical Outcome of Decompression and Fixation of Degenerative Lumbosacral Spondylolisthesis Surgery in Pakistani Population
  17. 1837
    “…In this study, we developed a new technique termed anterior cantilever procedure to directly reduce the slippage of high-grade lumbosacral spondylolisthesis. …”
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    Direct reduction of high-grade lumbosacral spondylolisthesis with anterior cantilever technique - surgical technique note and preliminary results
  18. 1838
    “…In addition to validating known molecular mechanisms, we discovered that the Sgl of PP7, an ssRNA phage of Pseudomonas aeruginosa, targets MurJ, the flippase responsible for lipid II export, previously shown to be the target of the Sgl of coliphage M. …”
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    Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins
  19. 1839
    “…Both experimental and theoretical results show that at small indentation angles (when the direction of motion is close to tangential), a mode with elastomer slippage relative to the indenter is observed, which leads to complex dynamic processes—the rearrangement of the contact boundary and the propagation of elastic waves (similar to Schallamach waves). …”
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    Indentation and Detachment in Adhesive Contacts between Soft Elastomer and Rigid Indenter at Simultaneous Motion in Normal and Tangential Direction: Experiments and Simulations
  20. 1840
    “…The global IgC-like fold is maintained, but a piston-like rearrangement between BC and DE β-turns results in β-strand slippage. This substantial conformational change may represent a signaling intermediate. …”
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    An Alternative Conformation of the T-Cell Receptor α Constant Region
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