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1861por Nakanishi, Akihito, Iritani, Kohei, Sakihama, Yuri, Ozawa, Nanami, Mochizuki, Ayano, Watanabe, Marina“…The cell layers were then repeatedly piled to increase the strength of the cell-plastic. To avoid slippage between the cell layers, they were covered with a small amount of a two-dimensional polymer to maintain the flat surface structure of the cell-plastic. …”
Publicado 2020
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1862“…Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. …”
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1863por Kiktev, Denis A, Dominska, Margaret, Zhang, Tony, Dahl, Joseph, Stepchenkova, Elena I, Mieczkowski, Piotr, Burgers, Peter M, Lujan, Scott, Burkholder, Adam, Kunkel, Thomas A, Petes, Thomas D“…Met18p is required for the efficient insertion of iron-sulfur clusters into various proteins. met18 mutants have an elevated rate of deletions between short flanking repeats, consistent with increased DNA polymerase slippage. This phenotype is very similar to that observed in mutants of POL3 (encoding the catalytic subunit of Pol δ) that weaken binding of the iron-sulfur cluster. …”
Publicado 2021
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1864por Zamudio-Ochoa, Angelica, Morozov, Yaroslav I, Sarfallah, Azadeh, Anikin, Michael, Temiakov, Dmitry“…In this work, we found that transcript slippage results in heterogeneity of the human mitochondrial transcripts in vivo and in vitro. …”
Publicado 2022
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1865“…This study discusses the role and function of helical design as it relates to slippage during translation of a vehicle in glass bead media. …”
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1866por Katsuta, Hiroki, Okuda, Satoru, Nagayama, Kazuaki, Machiyama, Hiroaki, Kidoaki, Satoru, Kato, Masashi, Sokabe, Masahiro, Miyata, Takaki, Hirata, Hiroaki“…A computational modeling analysis suggested that lowering the density of actin crosslinks caused viscous slippage of actin filaments in SFs and, thereby, dissipated myosin-generated force transmitting along SFs. …”
Publicado 2023
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1867“…During apoptosis, the exposure of phosphatidylserine to the outer surface of a cell is driven by the membrane scramblases and flippases, the activities of which are regulated by caspases. …”
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1868“…An arf1Δ synthetic lethal screen identified SWA3/DRS2, which encodes an integral membrane P-type ATPase and potential aminophospholipid translocase (or flippase). The drs2 null allele is also synthetically lethal with clathrin heavy chain (chc1) temperature-sensitive alleles, but not with mutations in COPI subunits or other SEC genes tested. …”
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1869por Islam, Salim T., Eckford, Paul D. W., Jones, Michelle L., Nugent, Timothy, Bear, Christine E., Vogel, Christian, Lam, Joseph S.“…Wzx flippases are crucial for bacterial cell surface polysaccharide assembly as they transport undecaprenyl pyrophosphate-linked sugar repeat units from the cytoplasmic to the periplasmic leaflets of the inner membrane (IM) for final assembly. …”
Publicado 2013
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1870por Yamane-Sando, Yukari, Shimobayashi, Etsuko, Shimobayashi, Mitsugu, Kozutsumi, Yasunori, Oka, Shogo, Takematsu, Hiromu“…Fpk1 and Fpk2 were involved in two downstream events; that is, ISP-1 uptake due to aminophospholipid flippase and LCB degradation due to LCB4 expression. …”
Publicado 2014
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1871“…Taken together, these data suggest a novel model of the early stages of apoptosis where membrane flippage results in removal of the inhibitory effect of ANXA5 on K(+) channel activity with the consequent amplification of Ca(2+) influx and augmented activation of caspases.…”
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1872“…Moreover, abrogation of the asymmetric distribution of plasmalogens in the plasma membrane by reducing the expression of CDC50A encoding a β-subunit of flippase elevates the expression level of Far1 and plasmalogen synthesis without reducing the total cellular level of plasmalogens. …”
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1873por Zhu, Biyun, Gao, Hua, Xu, Gang, Wu, Dewei, Song, Susheng, Jiang, Hongshan, Zhu, Shuifang, Qi, Tiancong, Xie, Daoxin“…We uncover that the membrane-localized flippase Aminophospholipid ATPase 1 (ALA1) cooperates with RDR6 and RDR1 to promote antiviral immunity and regulate fertility in Arabidopsis. …”
Publicado 2017
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1874por Takasugi, Nobumasa, Araya, Runa, Kamikubo, Yuji, Kaneshiro, Nanaka, Imaoka, Ryosuke, Jin, Hao, Kashiyama, Taku, Hashimoto, Yoshie, Kurosawa, Masaru, Uehara, Takashi, Nukina, Nobuyuki, Sakurai, Takashi“…TMEM30A is a subcomponent of lipid flippase that translocates phospholipids from the outer to the inner leaflet of the lipid bilayer. …”
Publicado 2018
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1875por Turapov, Obolbek, Forti, Francesca, Kadhim, Baleegh, Ghisotti, Daniela, Sassine, Jad, Straatman-Iwanowska, Anna, Bottrill, Andrew R., Moynihan, Patrick J., Wallis, Russell, Barthe, Philippe, Cohen-Gonsaud, Martin, Ajuh, Paul, Vollmer, Waldemar, Mukamolova, Galina V.“…Furthermore, we show that the partner proteins for the phosphorylated and non-phosphorylated forms of CwlM are FhaA, a fork head-associated domain protein, and MurJ, a proposed lipid II flippase, respectively. From our results, we propose a model in which CwlM potentially regulates both the biosynthesis of peptidoglycan precursors and their transport across the cytoplasmic membrane.…”
Publicado 2018
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1876“…This study explains how the alternating access mechanism and the flippase activity in ABC exporters could be lipid-dependent.…”
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1877por Grand, Morgane, Waqasi, Mishelle, Demarta-Gatsi, Claudia, Wei, Yu, Peronet, Roger, Commere, Pierre-Henri, Puig, Amandine, Axelrod, Jonathan, Caldelari, Reto, Heussler, Volker, Amino, Rogerio, Mecheri, Salaheddine“…Here, we used mice deficient in the multidrug resistance-2 gene (Mdr2(−/−))-encoded phospholipid flippase leading to the development of liver inflammation. …”
Publicado 2020
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1878por Wang, Weihong, Wu, Shaoxian, Cen, Zhanpeng, Zhang, Yixin, Chen, Yuang, Huang, Yixian, Cillo, Anthony R., Prokopec, Joshua S., Quarato, Giovanni, Vignali, Dario A.A., Stewart-Ornstein, Jacob, Li, Song, Lu, Binfeng, Gong, Yi-Nan“…Herein, we established PS(out) tumor models with tumor cells lacking PS flippase component CDC50A, constantly exposing PS but alive. …”
Publicado 2022
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1879“…The information obtained from this work could help us in designing novel drugs for P-type flippase disorders.…”
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1880“…REVIEWERS: This article was reviewed by Dr Rob Knight, Dr Josh Cherry (nominated by Dr David Lipman) and Dr Stephen Altschul (nominated by Dr David Lipman).…”
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