“…Whereas high-risk MYCN-amplified neuroblastomas were characterized by signs of replication slippage and stress, homologous recombination-associated signatures defined high-risk non-MYCN-amplified patients. …”
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“…The quasipalindromic nature of the target sequence and its potential to form DNA secondary structures and slippage mismatches appear to be an important basis for the mutability of this allele.…”
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“…Previously, generation of such repeats was hindered by CTG repeat instability in plasmid vectors maintained in Escherichia coli and poor in vitro ligation of CTG repeat concatemers due to strand slippage. Instead, we used a combination of in vitro ligation and ϕ29 DNA polymerase to amplify DNA. …”
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“…A partial stacking is observed with a centroid–centroid distance of 3.830 (2) Å, a perpendicular distance of 3.350 Å and a slippage of 1.856 Å.…”
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“…In addition, π–π inter­actions also contribute to the crystal packing, with a centroid-to-centroid distance of 3.693 (6) Å and a slippage angle of 1.614°. A significant number of conformational differences are observed between the salt in the crystal structure and the models obtained by density functional theory (DFT) calculations of the geometry-optimized structure.…”
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“…The 1,2-di-4-pyridylethane N,N′-dioxide mol­ecule is located on an inversion center. π–π stacking inter­actions between neighboring 1,2-di-4-pyridylethane N,N′-dioxide mol­ecules are observed with a centroid–centroid distance of 3.613 Å, an inter­planar distance of 3.317 Å, and a slippage of 1.433 Å. O—H⋯O hydrogen-bonding inter­actions between 1,2-di-4-pyridylethane N,N′-dioxide and acetic acid mol­ecules result in distinct hydrogen-bonded units made of one N-oxide and two acetic acid mol­ecules. …”
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“…Upon prolonged activation of the spindle assembly checkpoint, cells escape from mitosis through a mechanism called adaptation or mitotic slippage, which is thought to underlie the resistance of cancer cells to antimitotic drugs. …”
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“…The bonding between iridium and the five-membered ring of the indenyl ligand shows the usual asymmetry associated with the typical ring slippage responsible for the enhanced activity of indenyl metal compounds when compared with the analogous cyclo­penta­dienyl metal compound. …”
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“…This was not an artifact of prevailing directions of current and swimming, nor was it an artifact of frictional slippage. Generalized additive modeling was used to decompose the pattern of swimming into spatial and temporal components. …”
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“…In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare.…”
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“…These effects of 1 on the trypanosome are reminiscent of “mitotic slippage” or endoreplication observed in some other eukaryotes.…”
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“…Knockdown of ATP8A1 (an RE PS-flippase) or evectin-2 (an RE-resident protein) and masking of PS in the cytoplasmic leaflet of membranes, all suppress nuclear localization of YAP and YAP-dependent transcription. …”
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“…In this paper, we construct a pneumatic tactile sensor and apply it on the fingertip of robot hand to realize the sensing of force, vibration and slippage via the change of the pressure of the air bladder, and we utilize the sensor to perceive the object’s features such as softness and roughness. …”
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“…We show that cell surface phosphatidylserine inhibits PIEZO1 and that the inward translocation of phosphatidylserine, which is driven by the phospholipid flippase complex of ATP11A and CDC50A, is required for PIEZO1 activation. …”
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“…Using a large mesh could cover the hernial orifice with a sufficient margin, reducing a risk of recurrence caused by shrinkage and slippage of the mesh. CONCLUSION: Our technique utilizing a large, lightweight, synthetic mesh can be practical and useful for perineal hernia repair after laparoscopic APR.…”
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“…Complications of laparoscopic adjustable gastric bands include migration and slippage of the band, dilation of the proximal gastric pouch, troublesome gastroesophageal reflux symptoms, and erosion of the stomach. …”
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“…We observed frequent slippage of the helicase, which is fully suppressed by the primase DnaG. …”
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“…APN2 also suppresses 2-bp slippage mutagenesis in RNH201-deficient cells. Our results define additional activities of Apn2 in resolving a wide range of 3’- end blocks and identify a role of Apn2 in maintaining genome integrity during rNMP repair.…”
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“…The slippage damage caused by weak interlaminar bonding between cement concrete deck and asphalt surface is a serious issue for bridge pavement. …”
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“…In addition, our study on two different gas species showed that the gas type affects slippage and apparent gas permeability. Finally, comparing different apparent permeability models showed that Beskok and Karniadakis model is valid only up to the early transition regime and at higher Knudsen numbers, the current data matches those models that take Knudsen diffusion into account as well.…”
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