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21por Ratz, Megan L., Leary, Greg, Grindeland, Andrea, Silvius, Derek, Guter, Joseph, Kavanaugh, Michael P., Gunn, Teresa M.“…SLC1A4 (solute carrier family 1 member 4, also referred to as ASCT1, Alanine/Serine/Cysteine/Threonine-preferring Transporter 1) is a sodium-dependent neutral amino acid transporter. …”
Publicado 2023
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23por Antonino de Souza Júnior, José Dijair, Ramos Coelho, Roberta, Tristan Lourenço, Isabela, da Rocha Fragoso, Rodrigo, Barbosa Viana, Antonio Américo, Lima Pepino de Macedo, Leonardo, Mattar da Silva, Maria Cristina, Gomes Carneiro, Regina Maria, Engler, Gilbert, de Almeida-Engler, Janice, Grossi-de-Sa, Maria Fatima“…In this study we have knocked-down an aspartic (Mi-asp-1), a serine (Mi-ser-1) and a cysteine protease (Mi-cpl-1) by RNAi interference to get an insight into the function of these enzymes during a host/nematode interaction. …”
Publicado 2013
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24por Chilà, Rosaria, Chiappa, Michela, Guffanti, Federica, Panini, Nicolò, Conconi, Donatella, Rinaldi, Andrea, Cascione, Luciano, Bertoni, Francesco, Fratelli, Maddalena, Damia, GiovannaEnlace del recurso
Publicado 2022
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25por Weigand, Tim, Colbatzky, Florian, Pfeffer, Tilman, Garbade, Sven F., Klingbeil, Kristina, Colbatzky, Florian, Becker, Michael, Zemva, Johanna, Bulkescher, Ruben, Schürfeld, Robin, Thiel, Christian, Volk, Nadine, Reuss, David, Hoffmann, Georg F., Freichel, Marc, Hecker, Markus, Poth, Tanja, Fleming, Thomas, Poschet, Gernot, Schmitt, Claus P., Peters, VerenaEnlace del recurso
Publicado 2020
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26por Huang, Guo-Ying, Xie, Li-Jian, Linask, Kaari L., Zhang, Chen, Zhao, Xiao-Qing, Yang, Yi, Zhou, Guo-Min, Wu, Ying-Jie, Marquez-Rosado, Lucrecia, McElhinney, Doff B., Goldmuntz, Elizabeth, Liu, Chengyu, Lampe, Paul D., Chatterjee, Bishwanath, Lo, Cecilia W.“…To further assess the possible role of Cx43 in CHD, we also generated two knock-in mouse models with point mutations at serine residues subject to protein kinase C or casein kinase phosphorylation, sites that are known to regulate gating and trafficking of Cx43, respectively. …”
Publicado 2011
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27por Gerlini, Raffaele, Amendola, Elena, Conte, Andrea, Valente, Valeria, Tornincasa, Mara, Credendino, Sara Carmela, Cammarota, Francesca, Gentile, Chiara, Di Guida, Luigi, Paladino, Simona, De Vita, Gabriella, Fusco, Alfredo, Pierantoni, Giovanna Maria“…The serine–threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) modulates important cellular functions during development, acting as a signal integrator of a wide variety of stress signals, and as a regulator of transcription factors and cofactors. …”
Publicado 2019
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28“…The pathogenesis of ovarian cancer (OC) is complex. Serine Protease 8 (PRSS8) is a potential biomarker for early detection of OC. …”
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29por Attoub, Samir, Arafat, Kholoud, Kamel Hammadi, Nasseredine, Mester, Jan, Gaben, Anne-MarieEnlace del recurso
Publicado 2015
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30“…We previously found that apoE is cleaved into a 25-kDa fragment by high temperature-requirement serine protease A1 (HtrA1) in SK-N-SH cells. To further understand the endogenous functions of apoE, we used CRISPR/Cas9 to generate SK-N-SH cell lines with APOE expression knocked-down (KD). …”
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31por Folini, Marco, Gandellini, Paolo, Longoni, Nicole, Profumo, Valentina, Callari, Maurizio, Pennati, Marzia, Colecchia, Maurizio, Supino, Rosanna, Veneroni, Silvia, Salvioni, Roberto, Valdagni, Riccardo, Daidone, Maria Grazia, Zaffaroni, NadiaEnlace del recurso
Publicado 2010
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32“…We have rigorously validated SPRINT’s effectiveness in detecting RESs using RNA-seq data of samples in which genes encoding RNA editing enzymes are knock down or over-expressed, and have also demonstrated its superiority over current methods. …”
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33por Passos, Vânia, Zillinger, Thomas, Casartelli, Nicoletta, Wachs, Amelie S., Xu, Shuting, Malassa, Angelina, Steppich, Katja, Schilling, Hildegard, Franz, Sergej, Todt, Daniel, Steinmann, Eike, Sutter, Kathrin, Dittmer, Ulf, Bohne, Jens, Schwartz, Olivier, Barchet, Winfried, Goffinet, Christine“…We generated, via CRISPR/Cas9-assisted gene editing, Jurkat T-cell clones expressing endogenous SERINC5 bearing an extracellularly exposed hemagglutinin (HA) epitope [Jurkat SERINC5(iHA knock-in) T cells]. …”
Publicado 2019
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34“…Our previous study demonstrated that an integrin β subunit of Chinese shrimp (Fenneropenaeus chinensis) (FcβInt) plays an important role in white spot syndrome virus (WSSV) infection. …”
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35por Gnanasekaran, Aswini, Bele, Tanja, Hullugundi, Swathi, Simonetti, Manuela, Ferrari, Michael D, van den Maagdenberg, Arn MJM, Nistri, Andrea, Fabbretti, Elsa“…The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in controlling P2X3 receptor expression and function in trigeminal ganglia from Cacna1a R192Q-mutated knock-in (KI) mice, a genetic model for familial hemiplegic migraine type-1. …”
Publicado 2013
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36“…The knockdown of the expression of MjSyn by RNA interference resulted in a significant decrease in the phagocytic ability and increased bacteria number in vivo of shrimp. Moreover, the expression of MjCnx, a cytoplasma and membrane location lectin chaperone protein, was inhibited in the MjSyn-knocked down shrimp, which indicated a possible calnexin-related way. …”
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38por Kolachala, Vasantha L., Palle, Sirish K., Shen, Ming, Shenoi, Asha, Shayakhmetov, Dmitry M., Gupta, Nitika A.“…Current understanding is that receptor interacting serine/threonine protein kinase 1 (RIPK1) can lead to two distinct forms of cell death: RIPK3‐mediated necroptosis or caspase 8 (Casp8)‐mediated apoptosis. …”
Publicado 2019
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39por Liang, Yan, Xu, Meng-Lin, Wang, Xiao-Wen, Gao, Xiao-Xiao, Cheng, Jun-Jun, Li, Chen, Huang, Jie“…In addition, RNAi was developed to knock down endogenous bp53. RESULTS: BP53 is present on shrimp cell surface of hemocytes and gill epithelia. …”
Publicado 2015
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40por Haugnes, Pål, Kocbach, Jan, Talsnes, Rune Kjøsen, Noordhof, Dionne, Ettema, Gertjan, Sandbakk, Øyvind“…Thirty elite male XC skiers (age: 24±3 years, sprint International Ski Federation [FIS] points: 61±27) performed a sprint time-trial (STT) followed by one to three ‘knock-out’ heats on a 1.7 km racecourse. …”
Publicado 2022
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