Mostrando 421 - 440 Resultados de 649 Para Buscar 'Knock Shrine~', tiempo de consulta: 3.05s Limitar resultados
  1. 421
    “…The serine protease inhibitor alpha1-antitrypsin (A1AT) may possess protective functions of impaired organs in a manner independent of its protease inhibitor activity. …”
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    Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression
  2. 422
    “…ERK3 (extracellular signal-regulated kinase 3) is an atypical member of the mitogen-activated protein (MAP) kinase family of serine/threonine kinases. Little is known about its function in mitosis, and even less about its roles in mammalian oocyte meiosis. …”
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    ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis
  3. 423
    “…AURKA, an oncogene, encodes a serine-threonine kinase which regulates mitotic processes in mammalian cells. …”
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    Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer
  4. 424
    “…Using liver metabolomics we have shown a starvation-like condition in a knock-in (Bcs1l(c.232A>G)) mouse model of GRACILE syndrome, a neonatal lethal respiratory chain complex III dysfunction with hepatopathy. …”
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    Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency
  5. 425
    “…ROP18 (TgROP18) is a serine-threonine kinase secreted by T. gondii rhoptry and a major virulence factor; however, the mechanisms by which this kinase modulates host factors remain poorly understood. …”
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    Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Phosphorylation of Vimentin is Partially Regulated by Interaction with TgROP18
  6. 426
    “…Kallikrein-related peptidases (KLKs) belong to a serine protease family with 15 members that play important roles in cellular physiological behavior and diseases. …”
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    Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer
  7. 427
    por Roe, Anne Jessica, Qi, Xin
    Publicado 2018
    “…Drp1 phosphorylation at serine 616 is increased in HD knock-in mouse derived striatal cells, which is abolished by treatment with U0126, a potent inhibitor of MEK1/2. …”
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    Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington’s disease
  8. 428
    “…The casein kinase 1 delta (CSNK1D) is a conserved serine/threonine protein kinase that regulates diverse cellular processes including cell cycle progression, circadian rhythm, and neurite outgrowth. …”
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    Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells
  9. 429
    “…Here, we report that HOIL-1 is an atypical E3 ligase that forms oxyester bonds between the C terminus of ubiquitin and serine and threonine residues in its substrates. Exploiting the sensitivity of HOIL-1–generated oxyester bonds to cleavage by hydroxylamine, and macrophages from knock-in mice expressing the E3 ligase-inactive HOIL-1[C458S] mutant, we identify IRAK1, IRAK2, and MyD88 as physiological substrates of the HOIL-1 E3 ligase during Toll-like receptor signaling. …”
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    The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells
  10. 430
    “…CDK5 phosphorylated PER2 at serine residue 394 (S394) in a diurnal fashion. This phosphorylation facilitated interaction with Cryptochrome 1 (CRY1) and nuclear entry of the PER2-CRY1 complex. …”
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    Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
  11. 431
    “…Moreover, PTEN-induced putative kinase 1 (PINK1), a mitochondrial serine/threonine-protein kinase, was inhibited by MEL during oxidative stress. …”
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    Melatonin Represses Mitophagy to Protect Mouse Granulosa Cells from Oxidative Damage
  12. 432
    “…The SERPINA1 gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80–90%) produced in the liver. …”
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    Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways
  13. 433
    “…Adaptor protein 2-associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases and plays a role in modulating receptor endocytosis. …”
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    Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
  14. 434
    “…Altered profiles of ATR target serine-glutamine motifs (SQ) on DDR-related hallmark proteins point to a defect in DNA damage sensing. …”
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    GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage
  15. 435
    “…As a consequence of androgen-stimulated activation, PAK6 was phosphorylated at multiple serine/threonine residues including the AR-interacting domain of PAK6. …”
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    Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation
  16. 436
    “…Ap-sHSP21.4 was highly expressed in fat body and up-regulated in midgut and fat body of A. pernyi challenged with Escherichia coli, Beauveria bassiana and nuclear polyhedrosis virus (NPV), which was determined by quantitative real-time PCR. Meanwhile, knock down of Ap-sHSP21.4 with dsRNA result in the decrease at the expression levels of several immune response-related genes (defensin, Dopa decarboxylase, Toll1, lysozyme and Kazal-type serine protease inhibitor). …”
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    Inhibitors of Eicosanoid Biosynthesis Influencing the Transcripts Level of sHSP21.4 Gene Induced by Pathogen Infections, in Antheraea pernyi
  17. 437
    “…We have employed knock-out MTB, and M. bovis BCG as a surrogate strain to elaborate the consequence of the phosphorylation of EspJ. …”
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    RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria
  18. 438
    “…METHODS: In the current study, the effects of 6 weeks of HIIT were examined using obese mice with serine–alanine knock-in mutations on the AMPK phosphorylation sites of ACC1 and ACC2 (AccDKI) or wild-type (WT) controls. …”
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    High intensity interval training improves liver and adipose tissue insulin sensitivity
  19. 439
    “…IR increased polyploidy and decreased G2/M arrest in dCK knock-down cells as compared with control cells. …”
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    The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death
  20. 440
    “…The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. …”
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    Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages
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