Mostrando 501 - 520 Resultados de 649 Para Buscar 'Knock Shrine~', tiempo de consulta: 2.12s Limitar resultados
  1. 501
    “…GOF p53 TAD mutations significantly reduce phosphorylation of nearby p53 serine 20 (S20), which is a target for PLK3 phosphorylation. …”
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    The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
  2. 502
    “…Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of cellular pro-proteins. …”
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    The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response
  3. 503
    “…Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad(3SA) knock-in mice, where BAD cannot undergo phosphorylation at 3 key serine residues, pubertal gland development is delayed due to aberrant tubulogenesis of the ductal epithelium. …”
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    BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
  4. 504
    “…A membrane-type metal dependent serine proteinase designated matriptase which contains β1-6 GlcNAc branching became resistant to auto-digestion and proteolysis by trypsin, and resulted in a constitutively active form which might be implicated in cancer invasion and metastasis. …”
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    Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer
  5. 505
    “…Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrillation and heart failure. …”
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    Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart
  6. 506
    “…In mouse dorsal root ganglion (DRG) neurons, without changing the biophysical properties of Na(V)1.7, metformin significantly decreased Na(V)1.7 current densities, but not in Nedd4L knock-out mice (SNS-Nedd4L(−/−)). In addition, metformin induced a significant reduction in NEDD4-2 phosphorylation at the serine-328 residue in DRG neurons, an inhibitory phosphorylation site of NEDD4-2. …”
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    The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na(V)1.7 via the Ubiquitin-Ligase NEDD4-2
  7. 507
    “…Arginine–serine (RS) domain(s) in splicing factors are critical for protein–protein interaction in pre‐mRNA splicing. …”
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    RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis
  8. 508
    “…Members of the HtrA family of serine proteases are known to play roles in mitochondrial homeostasis as well as in programmed cell death. …”
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    Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress
  9. 509
    “…Immune function and colonic injury were investigated by inflammatory gene expression (NanoString) and histology. Colitis severity and underlying pathways were investigated in C57BL/6, Nucleotide-binding Oligomerization Domain-2 knock-out (Nod2(-/-)), and Protease-Activated Receptor 2 (PAR2) cleavage resistant mice (R38E-PAR2) subjected to 2% dextran sodium sulfate in drinking water for 5 days followed by 2 days on water. …”
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    A3 CROHN’S DISEASE PROTEOLYTIC MICROBIOTA ENHANCES INFLAMMATION THROUGH PAR2 PATHWAY IN GNOTOBIOTIC MICE
  10. 510
    “…BACKGROUND: LATS2, which encodes a novel serine/threonine kinase, is known to be important in centrosome duplication and in the maintenance of genomic stability. …”
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    LATS2 is De-methylated and Overexpressed in Nasopharyngeal Carcinoma and Predicts Poor Prognosis
  11. 511
    “…CITED2 is a transcriptional co-activator with 3 conserved domains shared with other CITED family members and a unique Serine-Glycine Rich Junction (SRJ) that is highly conserved in placental mammals. …”
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    Functional Significance of SRJ Domain Mutations in CITED2
  12. 512
    “…NS is caused by loss-of-function mutations in SPINK5 encoding the LEKTI serine protease inhibitor. LEKTI deficiency results in unopposed activities of kallikrein-related peptidases (KLKs) and aberrantly increased proteolysis in the epidermis. …”
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    KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
  13. 513
    “…Analyses of post‐mortem brain tissue from idiopathic and LRRK2 G2019S carriers reveal an increase in PAK6 activation state, whereas knock‐out LRRK2 mice display reduced PAK6 activation and phosphorylation of PAK6 substrates. …”
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    Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain
  14. 514
    “…Their expression was induced by 3-, 3-, 6-, 3-, 11- and 7-fold, respectively. STRING analysis confirmed protein-protein-interactions of regulated genes and Western immunoblotting of fatty acid synthase, serine hydroxyl-methyltransferase 1, arginine 1 and hexokinase 2 showed tumor specific induction. …”
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    c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma
  15. 515
    “…Similarly, alpha-synuclein knock-out mice show increased neuronal DSBs that can be rescued by transgenic reintroduction of human alpha-synuclein. …”
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    Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
  16. 516
    “…RATIONALE: Protein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide array of signaling pathways. …”
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    Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection
  17. 517
    por Marlaire, Simon, Dehio, Christoph
    Publicado 2021
    “…Interactomic analysis revealed binding of BepC to a complex of the Rho guanine nucleotide exchange factor GEF-H1 and the serine/threonine-protein kinase MRCKα. Knock-out cell lines revealed that only GEF-H1 is required for mediating BepC-triggered stress fiber formation and inhibitor studies implicated activation of the RhoA/ROCK pathway downstream of GEF-H1. …”
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    Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane
  18. 518
    “…We hypothesized that the AhR enhances the activation of the AKT serine/threonine kinase (Akt) pathway to promote cell survival. …”
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    Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
  19. 519
    “…Serine-167 (S167) is a major phosphorylation site in estrogen receptor alpha (ERα) and a predictor for endocrine therapy response in breast cancer. …”
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    OR26-2 Phosphorylation of Estrogen Receptor Alpha is Required for Mammary Gland Development and MCF-7 Breast Tumor Response to Estradiol and Tamoxifen
  20. 520
    “…The knock-out of either BLP1 or BLP2 genes of the A. baumannii ST1 AYE strain severely affected biofilm formation, as measured by comparing biofilm biomass and thickness, and adherence to epithelial cells. …”
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    Biofilm-associated proteins: news from Acinetobacter
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