Mostrando 621 - 640 Resultados de 649 Para Buscar 'Knock Shrine~', tiempo de consulta: 2.00s Limitar resultados
  1. 621
    “…Using RNA interference (RNAi), we individually knocked down each gene in third instar larvae and measured the effects on development. …”
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    Comparative transcriptomics of the irradiated melon fly (Zeugodacus cucurbitae) reveal key developmental genes
  2. 622
    “…OBJECTIVES: The NEK2 (never in mitosis gene A-related kinase 2), a serine/threonine kinase involved in chromosome instability and tumorigenesis. …”
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    NEK2 promotes esophageal squamous cell carcinoma cell proliferation, migration and invasion through the Wnt/β-catenin signaling pathway
  3. 623
    “…RESULTS: We showed that knocking down of Sf-15 can inhibit the proliferation, then induce apoptosis of insect S. frugiperda Sf9 cells, but the results were reversed when Sf-15 was overexpressed. …”
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    Small nucleolar RNA Sf-15 regulates proliferation and apoptosis of Spodoptera frugiperda Sf9 cells
  4. 624
    “…In contrast, upon hyperactivation of mechanistic target of rapamycin complex 1 signaling by knocking-down tuberous sclerosis complex protein, we observed increased susceptibility to cell death in response to energy stress in both pancreatic and non-pancreatic β cells. …”
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    Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status
  5. 625
    “…BACKGROUND: Death-associated protein kinase 2 (DAPK2) is a serine/threonine kinase, which has been implicated in autophagy and apoptosis. …”
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    DAPK2 activates NF-κB through autophagy-dependent degradation of I-κBα during thyroid cancer development and progression
  6. 626
    “…Moreover, MCF-7 cells acquired the ability to invade in 2D and 3D cell culture when PKD1 expression was knocked-down by shRNA. PKD1 also regulated the expression of breast cancer cell MMPs, MMP-2, MMP-7, MMP-9, MMP-10, MMP-11, MMP-13, MMP-14 and MMP-15, providing a potential mechanism for PKD1 mediation of the invasive phenotype. …”
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    Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion
  7. 627
    “…BACKGROUND: The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. …”
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    Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity
  8. 628
    “…STAT3 and c-Jun genes were knocked out using siRNA transfection. VEGF expression was determined by mRNA and protein levels by RT-PCR and western blotting. …”
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    Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells
  9. 629
    “…The transmembrane protease serine 2:v-ets erythroblastosis virus E26 oncogene homolog (TMPRSS2:ERG) gene fusion is common in prostate cancer, while its functional role is not fully understood. …”
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    Significance of the TMPRSS2:ERG gene fusion in prostate cancer
  10. 630
    “…Additionally, the AIF-1 gene was overexpressed and knocked down in macrophage RAW264.7 cells, and the effects of aldosterone on PI3K, AKT, mTOR, NOX2 and Nrf2 were subsequently investigated. …”
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    Aldosterone promotes renal interstitial fibrosis via the AIF-1/AKT/mTOR signaling pathway
  11. 631
    “…Serine/threonine protein phosphatase 2A (PP2A) is a protein that has a wide range of biological functions. …”
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    PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer
  12. 632
    “…This CD99 CAR demonstrated the ability to dramatically shrink the established orthotopic DIPG tumor, however tumor recurrence remains an obstacle to cure, due to a loss of the CAR-T cells as they also express the target antigen, CD99 (fratricide). …”
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    IMMU-23. Novel gene-edited CAR-T cell therapy against Diffuse Intrinsic Pontine Glioma
  13. 633
    “…When LmPrx6 was knocked down, the diapause rate was significantly reduced. …”
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    The Function of LmPrx6 in Diapause Regulation in Locusta migratoria Through the Insulin Signaling Pathway
  14. 634
    “…Under ABA treatment, the plants in which OsANN4 was knocked down by RNA interference showed some visible phenotypic changes compared to the wild type, such as a lower rooting rate and shorter shoot and root lengths. …”
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    OsANN4 modulates ROS production and mediates Ca(2+) influx in response to ABA
  15. 635
    “…METHODS: The dCas9-SAM and CRISPR/Cas9 techniques were used to construct viruses with overexpressed and knocked down AQP8, respectively, and infect A172 and U251 cell lines. …”
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    AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway
  16. 636
    “…We found that Nasrat, Closca, and Polehole structural proteins, together with the Nudel serine protease, are indispensable for eggshell melanization and egg viability. …”
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    Characterization of essential eggshell proteins from Aedes aegypti mosquitoes
  17. 637
    “…To investigate the impact on the cell proliferation, migration, and tumorigenicity in vitro, PAF-AH IB2 stable knocking down (KD) ovarian cancer cells were established by ShRNA. …”
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    Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer
  18. 638
    “…Exogenous VEGF-B also reduced the expression of phospholipase C gamma 1 (PLCγ1), phosphatidylinositol 3-kinase (PI3K), serine/threonine kinase (AKT), and other proteins in the insulin secretion pathway. …”
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    Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca(2+) and cyclic adenosine monophosphate levels through PI3K/AKT pathway
  19. 639
    “…Here we isolated nine mutants, in which the nif and nif-related genes were individually knocked out in L. boryana to investigate the individual functions of (1) accessory proteins (NifW, NifX/NafY, and NifZ) in the biosynthesis of nitrogenase metallocenters, (2) serine acetyltransferase (NifP) in cysteine supply for iron-sulfur clusters, (3) pyruvate formate lyase in anaerobic metabolism, and (4) NifT and HesAB proteins. …”
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    Accessory Proteins of the Nitrogenase Assembly, NifW, NifX/NafY, and NifZ, Are Essential for Diazotrophic Growth in the Nonheterocystous Cyanobacterium Leptolyngbya boryana
  20. 640
    “…Transmembrane protease serine 2 (TMPRSS2) demonstrates proteolytic activity, resulting in degradation of the extracellular matrix (ECM). …”
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    Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2
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