Mostrando 101 - 120 Resultados de 649 Para Buscar 'Knock Shrine~', tiempo de consulta: 2.04s Limitar resultados
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    “…Finally, Western blot analysis revealed no genotype difference in striatal levels of endogenous α-synuclein or α-synuclein bound to DOPAL (a toxic metabolite of dopamine). However, Serine129-phosphorylated α-synuclein levels were higher in 12-month-old G2019S knock-in mice. …”
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    “…Here, we showed that H(2)S/H(2)S(2) applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and d-serine, a co-agonist of NMDA receptors. Animals with genetically knocked-out 3MST and the target of H(2)S(2), transient receptor potential ankyrin 1 (TRPA1) channels, revealed that H(2)S/H(2)S(2), 3MST, and TRPA1 activation play a critical role in LTP induction, and the lack of 3MST causes behavioral hypersensitivity to NMDA receptor antagonism, as in schizophrenia. …”
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    “…Here, we show that upon HS, lamin A/C was reversibly phosphorylated at serine 22 in concert with HSF1 activation in human cells, mouse cells and Drosophila melanogaster in vivo. …”
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    “…Here we demonstrate that a-Syn significantly inhibited TH activity in vitro and in vivo and that phosphorylation of a-Syn serine 129 (Ser-129) modulated this effect. In MN9D cells, a-Syn overexpression reduced TH serine 19 phosphorylation (Ser(P)-19). …”
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    “…OBJECTIVE AND METHODS: We examined the contributions of D-serine to AD pathology in the App(NL–G–F/NL–G–F) gene knock-in (APPKI) mouse model of AD. …”
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    “…A primary example of this approach was to study mice with a myeloid-specific knock-out of the lipid-regulated transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) which is strikingly depressed in sarcoidosis. …”
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