Mostrando 41 - 60 Resultados de 103 Para Buscar 'Knocked Out Loaded', tiempo de consulta: 2.47s Limitar resultados
  1. 41
    “…Our earlier studies utilizing transgenic mice containing whole-body HKDC1 knockdown, or mice in which hepatic HKDC1 was overexpressed or knocked out, indicated that HKDC1 is important for whole-body glucose homeostasis in aging and pregnancy, through modulation of glucose tolerance, peripheral tissue glucose utilization, and hepatic energy storage. …”
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    RF04 | PSUN297 Genetic Knockout of Intestinal Hexokinase Domain Containing Protein-1 Affects Enterocyte Glucose Transport in Mice Fed High Fat Diet
  2. 42
    “…To further dissect the role of respiration in Microchloropsis mixotrophy, we focused on the mitochondrial alternative oxidase (AOX), a protein involved in energy management in other algae prospering in mixotrophy. Knocking-out the AOX1 gene by transcription activator-like effector nuclease (TALE-N) led to the loss of capacity to implement growth upon addition of LB supporting the hypothesis that the effect of this medium was related to a provision of reduced carbon. …”
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    Consequences of Mixotrophy on Cell Energetic Metabolism in Microchloropsis gaditana Revealed by Genetic Engineering and Metabolic Approaches
  3. 43
    “…Methods: A large number of minicells were produced by knocking out the minCD gene and enhancing the minE expression in EcN. …”
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    E. coli Nissle 1917-Derived Minicells for Targeted Delivery of Chemotherapeutic Drug to Hypoxic Regions for Cancer Therapy
  4. 44
    “…METHODS: To study CCR2 and CCR5 in inflammatory liver injury, we used mice with a hepatocyte-specific knock-out of the nuclear factor κB (NF-κB) essential modulator (NEMO), termed NEMO(LPC-KO) mice, and generated NEMO(LPC-KO)Ccr2(-/-) and NEMO(LPC-KO)Ccr5(-/-) mice. …”
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    Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion
  5. 45
    “…Interestingly, we show that H3.3 depletion has a differential effect depending on which of the two genes coding for H3.3, H3f3a or H3f3b, are knocked out. Depletion of H3f3a resulted in a transient upregulation of incoming retroviral expression and ERVs, while the depletion of H3f3b did not have the same effect and repression was maintained. …”
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    Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells
  6. 46
    “…Depleting tumor mitochondrial DNA or knocking out STING in APCs compromises the activation of APCs. …”
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    Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity
  7. 47
    “…We observe that both PDS5A and PDS5B are exclusively located at cohesin-CTCF positions and that ablation of a single paralog has no noticeable consequences for cohesin distribution while double knocked out cells show decreased accumulation of cohesin at all its binding sites. …”
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    Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
  8. 48
    “…Critically, in myocytes isolated from nitric oxide synthase 1 knock-out mice this effect is ablated. We show that isoproterenol stimulation leads to an increase in nitric oxide production, and nitric oxide alone is sufficient to activate CaMKII and increase SR Ca(2+) leak. …”
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    Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation
  9. 49
    “…H7 scFv(2)-Fc format elimination half-life was similar in FcRn knock-out and wild type mice, suggesting that TfR1 recycling contributes to prevent H7 elimination in vivo. …”
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    A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions
  10. 50
    “…To determine the effect of disulfide formation on PKARIα catalytic activity and subcellular localization, live-cell fluorescence imaging and stimulated emission depletion super-resolution microscopy were performed in prkar1 knock-out mouse embryonic fibroblasts, neonatal myocytes, or adult LV myocytes isolated from “redox dead” (Cys17Ser) PKARIα knock-in mice and their wild-type littermates. …”
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    Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release
  11. 51
    “…As such, no in vivo phenotype of a viral miRNA knock-out mutant has been described so far. Here, we report on the first functional phenotype of a miRNA knock-out virus in vivo. …”
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    Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
  12. 52
    “…To do that, we carried out records of intraventricular pressure and CSF outflow, and evaluated ventricular volume by magnetic resonance imaging in AQP1(−/−), AQP4(−/−), double AQP1(−/−)-AQP4(−/−) knock out and wild type mice controls. …”
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    AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
  13. 53
    “…Knocking out GJC1 (Cx45) abolished GJIC, as analyzed by the I-YFP assay and dual whole-cell patch-clamp assay. …”
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    Confirmation of Connexin45 Underlying Weak Gap Junctional Intercellular Coupling in HeLa Cells
  14. 54
    “…Our previous work has shown 24 h rhythmic changes in gene expression at transcript level between night and day in wild type mouse cartilage which is lost in a circadian clock knock-out mouse model. However, it remains unknown to what extent circadian rhythms also regulate protein level gene expression in this matrix rich tissue. …”
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    Circadian time series proteomics reveals daily dynamics in cartilage physiology
  15. 55
    “…Furthermore, our analysis indicates that the accumulation of nitrate in the shoot does not affect the nodulation and N-Fixation capacities of the knock out mutants. CONCLUSIONS: This study shows that LjNPF2.9 plays a crucial role in the downward transport of nitrate to roots, occurring likely through a xylem-to-phloem loading-mediated activity. …”
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    Disruption of the Lotus japonicus transporter LjNPF2.9 increases shoot biomass and nitrate content without affecting symbiotic performances
  16. 56
    “…METHODS AND FINDINGS: Surprisingly, both LXRα knock-out and LXRα/LXRβ double-knock-out (DKO) mice were markedly resistant to systemic L. chagasi/infantum infection compared to wild-type mice. …”
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    LXR Deficiency Confers Increased Protection against Visceral Leishmania Infection in Mice
  17. 57
    “…In the experimental model, bacterial load in the bladder (20-fold) and kidneys (300-fold) was significantly higher in PAD4 knock-out mice than in wild-type mice. …”
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    Neutrophil extracellular traps in urinary tract infection
  18. 58
    “…In this study, we succeeded in producing tomato lines with high sugar content without a decrease in fruit weight and deterioration of plant growth by knock-out of SlINVINH1 using genome editing technology. …”
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    Functional disruption of cell wall invertase inhibitor by genome editing increases sugar content of tomato fruit without decrease fruit weight
  19. 59
    por Tang, Long
    Publicado 2021
    “…First, simple methods such as visual inspection, knock and dragging-chain methods are used to determine the potential damage, and then radiation, modal analysis and load experiments are used to determine the damage mode and degree. …”
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    Maintenance and Inspection of Fiber-Reinforced Polymer (FRP) Bridges: A Review of Methods
  20. 60
    “…Previous studies have shown that increase compression ratio (CR) is an effective way to improve thermal efficiency of gasoline engine without changing the mechanical structure and working cycle, however, it is limited by engine knock when increasing the intake boosting under high load operation. …”
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    Numerical investigation of Miller cycle with EIVC and LIVC on a high compression ratio gasoline engine
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