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  1. 14521
    “…One of the earliest symptoms of bulbar involvement is voice deterioration characterized by grossly defective articulation; extremely slow, laborious speech; marked hypernasality; and severe harshness. …”
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    Detection of Bulbar Involvement in Patients With Amyotrophic Lateral Sclerosis by Machine Learning Voice Analysis: Diagnostic Decision Support Development Study
  2. 14522
    “…A manual chart review for ARDS diagnosis could be laborious and time-consuming. We developed an automated search strategy to retrospectively identify ARDS patients using the Berlin definition to allow for timely and accurate ARDS detection. …”
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    Derivation and Validation of an Automated Search Strategy to Retrospectively Identify Acute Respiratory Distress Patients Per Berlin Definition
  3. 14523
    “…This platform is, therefore, potentially applicable for field measurements of Pb in developing countries, because it is cheap and rapid, and it requires no significant laborious instruments.…”
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    A Simple Distance Paper-Based Analytical Device for the Screening of Lead in Food Matrices
  4. 14524
    “…However, conventional methods to screen for such microorganisms using whole plants and pathogens are generally laborious and time consuming. Here, we describe a general strategy using cultured plant cells to identify microorganisms that activate plant defense responses based on plant–microbe interactions. …”
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    An efficient direct screening system for microorganisms that activate plant immune responses based on plant–microbe interactions using cultured plant cells
  5. 14525
    “…Conventional and gold standard methods for the detection and characterization of parasites are time-consuming, laborious, and have low sensitivity. A polymerase chain reaction followed by high resolution melting (PCR-HRM) analysis has been employed for detection and species identification. …”
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    High resolution melting assay in discrimination of the main etiologic agents of leishmaniasis in Iran
  6. 14526
    “…Generation of conditional knockout (cKO) and various gene-modified cells is laborious and time-consuming. Here, we established an all-in-one cKO system, which enables highly efficient generation of cKO cells and simultaneous gene modifications, including epitope tagging and reporter gene knock-in. …”
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    A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing
  7. 14527
    “…Studying IAV involves laborious secondary methodologies to identify infected cells. …”
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    Replication-Competent ΔNS1 Influenza A Viruses Expressing Reporter Genes
  8. 14528
    “…Although the high-throughput biotechnologies have made tremendous progress, the indispensable clinical trials remain to be expensive, laborious, and intricate. Therefore, a convenient and reliable computer-aided method has become the focus on inferring drug-target interactions (DTIs). …”
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    An Ensemble Learning-Based Method for Inferring Drug-Target Interactions Combining Protein Sequences and Drug Fingerprints
  9. 14529
    “…CONCLUSION: Asking questions to patients receiving infertility treatment or anaesthesia is important in terms of medication interactions and treatment success. For a laborious and costly treatment, such as IVF, detailed history should be taken and herbal product used and cessation times must be searched in detail.…”
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    Evaluation of Herbal Product Use and Preanaesthetic Questioning of Couples Undergoing In Vitro Fertilisation
  10. 14530
    por Riazuelo, Hélène
    Publicado 2021
    “…The disease regularly disrupts the daily life of the couple and the family. This leads to a reworking of family relations. Each couple has its own history with the condition. …”
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    Couples Coping With the Serious Illness of One of the Partners
  11. 14531
    “…While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. …”
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    Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
  12. 14532
    “…Despite recent reports of neutralizations using different pseudoviruses with a luciferase or green fluorescent protein reporter, the laborious steps, inter-assay variability or high background limit their high-throughput potential. …”
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    A real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter
  13. 14533
    “…In cellulo crystallization represents a comparatively un­explored space in crystallization, especially for proteins that are resistant to crystallization using conventional techniques, and eliminates any need for laborious protein purification. This in-chip technique avoids harvesting the sensitive crystals or any further physical handling of the crystal-containing cells. …”
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    A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip
  14. 14534
    “…Bison grazing was responsible for small-scale changes in vegetation through trampling, wallowing and debarking, thus creating more open and disturbed plant communities, soil compaction and xerophytization. …”
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    Effects of large herbivore grazing on relics of the presumed mammoth steppe in the extreme climate of NE-Siberia
  15. 14535
    “…Although advanced imaging techniques, such as light-sheet fluorescent microscopy (LSFM), provide an accurate procedure for analyzing the heart structure, rapid, and robust segmentation is required to reduce laborious time and accurately quantify developmental cardiac mechanics. …”
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    Automatic Segmentation and Cardiac Mechanics Analysis of Evolving Zebrafish Using Deep Learning
  16. 14536
    “…Given that experimental verification of virulence factors is time-consuming and laborious, few virulence factors have been characterized. …”
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    Network-based analysis of virulence factors for uncovering Aeromonas veronii pathogenesis
  17. 14537
    “…Generally, EEG recordings produce vast amount of data with dynamic behavior, which are visually analyzed by professional clinician to detect autism. It is laborious, expensive, subjective, error prone and has reliability issue. …”
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    A spectrogram image based intelligent technique for automatic detection of autism spectrum disorder from EEG
  18. 14538
    “…The approach contrasts conventional routines that typically relies on hand-crafted, heuristic feature extraction and often laborious manual curation. The algorithm is trained using supervised learning on hand-curated data sets with SPW-R events obtained under controlled conditions. …”
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    RippleNet: a Recurrent Neural Network for Sharp Wave Ripple (SPW-R) Detection
  19. 14539
    “…Currently, fluorescence in situ hybridization (FISH) is the most widely used molecular cytogenetic technique to detect these aberrations. However, FISH is laborious, time-consuming, expensive, and has a low throughput. …”
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    Evaluation of MLPA as a comprehensive molecular cytogenetic tool to detect cytogenetic markers of chronic lymphocytic leukemia in Egyptian patients
  20. 14540
    “…Even with yeast cells, however, ageing assays can be laborious and resource-intensive. Here we present improved experimental and computational methods to study chronological lifespan in Schizosaccharomyces pombe. …”
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    Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast
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