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  1. 14681
    “…Experimentally measuring G-quadruplexes is a long and laborious process. Computational prediction of G-quadruplex propensity from a given DNA sequence is thus a long-standing challenge. …”
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    Online Artículo Texto
    G4mismatch: Deep neural networks to predict G-quadruplex propensity based on G4-seq data
  2. 14682
    “…Detection of the whole mitochondrial genome (mtGenome) using traditional Sanger-type sequencing is laborious and time-consuming. Additionally, its ability to distinguish point heteroplasmy (PHP) and length heteroplasmy (LHP) is limited. …”
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    Whole Mitochondrial Genome Detection and Analysis of Two- to Four-Generation Maternal Pedigrees Using a New Massively Parallel Sequencing Panel
  3. 14683
    “…However, the identification of SILs is usually laborious and has low diagnostic consistency due to the high similarity of pathological SIL images. …”
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    Online Artículo Texto
    Deep Learning-Based Recognition of Cervical Squamous Interepithelial Lesions
  4. 14684
    “…Unfortunately, current commercially available extraction kits are expensive and involve time-consuming and laborious extraction procedures. To overcome the difficulties associated with common extraction methods, we propose a simple enzymatic assay for the nucleic acid extraction step using heat mediation to improve the polymerase chain reaction (PCR) reaction sensitivity. …”
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    Low-Cost, Real-Time Polymerase Chain Reaction System with Integrated RNA Extraction
  5. 14685
    “…Second, manual annotation on whole-slide images is tedious, laborious and subject to intraobserver variability, which causes the supervised information restricted to limited, easily identifiable and scattered cells annotated by humans. …”
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    Online Artículo Texto
    CW-NET for multitype cell detection and classification in bone marrow examination and mitotic figure examination
  6. 14686
    “…Diagnosing Migraine Disease (MD) can be laborious and time-consuming for specialists. For this reason, systems that can assist specialists in the early diagnosis of MD are important. …”
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    A New Hybrid Approach Based on Time Frequency Images and Deep Learning Methods for Diagnosis of Migraine Disease and Investigation of Stimulus Effect
  7. 14687
    por Zhang, X. R., Ma, T., Wang, Y. C., Hu, S., Yang, Y.
    Publicado 2023
    “…However, conventional methods of C. auris identification are time-consuming and laborious and have low sensitivity and high error rates. …”
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    Online Artículo Texto
    Development of a Novel Method for the Clinical Visualization and Rapid Identification of Multidrug-Resistant Candida auris
  8. 14688
    “…The combined FallRS score had a slightly better AUC of 0.70 (95% CI, 0.65–0.75) but was more laborious to compute than the two other scores. At a cutoff of 13 points, the FallRS had a specificity of 77% and a sensitivity of 49% in predicting falls. …”
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    Online Artículo Texto
    Prediction of In-Hospital Falls Using NRS, PACD Score and FallRS: A Retrospective Cohort Study
  9. 14689
    “…Previous studies with model organisms laid the foundation of our knowledge on post-implantation development; however, studying mammalian embryos at this stage is a difficult and laborious process. Early attempts to recapitulate mammalian development in vitro begun with embryoid bodies (EBs), in which aggregates of mouse embryonic stem cells (mESCs) were shown to differentiate into spatially arranged germ layers. …”
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    A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues
  10. 14690
    “…Efforts to identify proteasome-interacting components and/or to solve its structure have relied on over-expression of a tagged plasmid, establishing stable cell lines, or laborious purification protocols to isolate native proteasomes from cells. …”
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    An engineered cell line with a hRpn1-attached handle to isolate proteasomes
  11. 14691
    “…Manual delineation of tumor regions in MRI images can be laborious and time-consuming, and results may be subjective and difficult to replicate. …”
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    Online Artículo Texto
    Comparative Analysis of Image Processing Techniques for Enhanced MRI Image Quality: 3D Reconstruction and Segmentation Using 3D U-Net Architecture
  12. 14692
    “…However, these methods often involve destructive processes, which are laborious, time-consuming, expensive, and environmentally harmful. …”
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    Online Artículo Texto
    Current Application of Advancing Spectroscopy Techniques in Food Analysis: Data Handling with Chemometric Approaches
  13. 14693
    “…Detecting stalled or slowed ribosomes in cells by ribosome footprint profiling or classic polysome profiling is laborious, technically challenging, and low throughput. …”
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    In vitro Analysis of Stalled Ribosomes Using Puromycin Incorporation
  14. 14694
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    The Influence of Sagittal Pin Angulation on the Stiffness and Pull-Out Strength of a Monolateral Fixator Construct
  15. 14695
    “…Similarly, analysing chromosomal damage in G0/G1 cells or nondividing cells by premature chromosome condensation is laborious. Following large-scale radiological emergencies, the time required for analysis is more important than precision of dose estimate. …”
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    Fluorescence in situ hybridisation for interphase chromosomal aberration-based biological dosimetry
  16. 14696
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    Accuracy of Wireless Hand-Held Guided Ultrasound Injections in the Trapeziometacarpal Joint: A Cadaveric Study
  17. 14697
    “…While nanoMIPs offer high affinity, robustness and reusability, their production can be tricky and laborious. Here we have developed a simple and rapid microwaveable suspension polymerisation technique to produce nanoMIPs for two related classes of drug targets, Selective Androgen Receptor Modulators (SARMs) and steroids. …”
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    A rapid synthesis of molecularly imprinted polymer nanoparticles for the extraction of performance enhancing drugs (PIEDs)
  18. 14698
    “…When compared to traditional machine learning methods for image processing, deep-learning methods can improve the accuracy of lung nodule diagnosis by avoiding the laborious pre-processing step of the picture (extraction of fake features, etc.). …”
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    Performance of Deep-Learning Solutions on Lung Nodule Malignancy Classification: A Systematic Review
  19. 14699
    “…CONCLUSION: Although more laborious and requiring a higher initial amount of material, the inclusion of an extraction and purification step allows to prepare RNA samples that are free from DNA and from low molecular contaminants and can be applied to amplify any Saccharomyces cerevisiae mRNA by RT-PCR.…”
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    Comparing protocols for preparation of DNA-free total yeast RNA suitable for RT-PCR
  20. 14700
    “…The characterisation process for each microsatellite locus can be laborious and costly given the need for numerous, locus-specific fluorescent primers. …”
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    High throughput, high resolution selection of polymorphic microsatellite loci for multiplex analysis
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