“…Generating the insights necessary to understand T cell immunity, experimentally, for the global human population is at present a critical but a time consuming, expensive, and laborious process. Further, it is not feasible to generate global or universal insights into T cell immunity in an actionable time frame for potential future emerging VOCs. …”
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“…Reconstruction after partial resection of the pelvis including the acetabulum or the hip joint is a laborious and rigorous surgical procedure. Numerous complications are associated with different reparative methods. …”
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“…However, the manual process is laborious and time-consuming. Recently, technological development has called for more efficient methods to meet species’ identification requirements, such as developing digital-image-processing and pattern-recognition techniques. …”
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“…Construction of large libraries can be laborious and occasionally errors will arise. Here, we present a rapid and accurate method for the validation of any ordered library where a gene has been replaced or disrupted by a uniform linear insertion (LI). …”
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“…A flexible, affordable, and rapid vaccine platform is necessary to unlock the potential of personalized cancer vaccines in order to achieve full clinical efficiency. mRNA cancer vaccine manufacture relies on the rigid sequence design of multiepitope constructs produced by laborious bacterial cloning and time-consuming plasmid preparation. …”
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“…The traditional method forecasts pest outbreaks by manually observing (capturing), identifying, and counting insects, which is very time-consuming and laborious. Therefore, developing a method that can more timely and accurately identify insects and obtain insect information. …”
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“…Quantification of the yield, energetic content, and chlorophyll a fluorescence (ChlF) remains laborious and is of great interest to physiologists and photobiologists. …”
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“…Protein modification with amine-reactive poly(ethylene glycol) (PEG) generates heterogeneous and complex bioconjugate mixtures, often composed of several PEG positional isomers with varied therapeutic efficacy. Laborious and costly experiments for reaction optimization and purification are needed to generate a therapeutically useful PEG conjugate. …”
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“…Experimental methods including mass spectrometry-based proteomics and yeast two-hybrid assays are widely used to identify human-virus PPIs, but these experimental methods are time-consuming, expensive, and laborious. To overcome this problem, we developed a novel computational predictor, named cross-attention PHV, by implementing two key technologies of the cross-attention mechanism and a one-dimensional convolutional neural network (1D-CNN). …”
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“…Therefore, various studies have been conducted to implement the silicification activity of R5 in different application areas, such as regenerative medicine and tissue engineering. However, laborious protein purification steps are required prior to silica nanoparticle production in recombinant approaches. …”
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“…However, MRI generates large amounts of data, making manual segmentation difficult and laborious work, limiting the use of accurate measurements in clinical practice. …”
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“…The sensitivity of these methods to small vessels can be increased by extensive parameter tuning or by manual corrections, albeit making them time-consuming, laborious, and not feasible for larger datasets. This paper proposes a deep learning architecture to automatically segment small vessels in 7 Tesla 3D Time-of-Flight (ToF) Magnetic Resonance Angiography (MRA) data. …”
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“…In vitro assays are frequently used for this purpose; however, traditional experimental approaches are insufficient for large-scale exploration of novel drug targets, as they are expensive, time-consuming and laborious. Therefore, computational methods have emerged in recent decades as an alternative to aid experimental drug discovery studies by developing sophisticated predictive models to estimate unknown drugs/compounds and their targets. …”
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“…However, the process of antibiotic discovery from natural sources is laborious and time-consuming as a result of outdated methodologies. …”
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“…Natural language processing (NLP) and machine learning have great potential to automate and accelerate such applications, but developing such models can require a large amount of labeled clinical text, which can be a slow and laborious process. To address this gap, we propose the MedDRA tagger, a fast annotation tool that makes use of industrial level libraries such as spaCy, biomedical ontologies and weak supervision to annotate and extract clinical concepts at scale. …”
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“…Analytical determination of N-nitrosamines is expensive, laborious, and time-inefficient making development of simpler and faster techniques for their detection crucial. …”
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“…Muscle atrophy is one of the significant complications in DM patients, making routine tasks laborious as atrophy continues. It is known that heat stress stimulates heat shock proteins and other proteins that maintain muscle mass; however, it is not thoroughly studied in diabetic conditions. …”
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“…Commercially available laboratory-based spectrometers are usually bulky and require high power and laborious manual processing, making them unsuitable to be deployed in portable and space-constrained environments, thereby further limiting their utility for real-time on-site monitoring. …”
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“…It is a quite quick, but laborious, method that should be tested for a larger number of concrete mixes. …”
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