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  1. 15021
    “…Nevertheless, traditional Sanger sequencing is laborious, time-consuming, and low throughput. Here, we compared two commercially available 16S rRNA gene sequencing tests that are based on Illumina and Nanopore sequencing technologies, respectively, in their ability to identify the species of 172 clinical isolates that failed to be identified by MALDI-TOF MS. …”
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    The Clinical Utility of Two High-Throughput 16S rRNA Gene Sequencing Workflows for Taxonomic Assignment of Unidentifiable Bacterial Pathogens in Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry
  2. 15022
    “…While the process of generating clusters has become largely automated, annotation remains a laborious ad hoc effort that requires expert biological knowledge. …”
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    CellMeSH: probabilistic cell-type identification using indexed literature
  3. 15023
    “…It does not require laborious manual annotation of ER whorls for training of deep learning models. …”
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    Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress
  4. 15024
    “…The ID (Vertical Electrical Sounding) and 2D resistivity inversion models results have revealed the heterogeneity nature of the topsoil, also known as the stone zone comprising of reworked clayey soil and sandy gravelly soil, the weathered/saprolite zone (gravelly sandy/sandy soil), the fractured basement and the fresh basement rock. …”
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    Geophysical and contamination assessment of soil spatial variability for sustainable precision agriculture in Omu-Aran farm, Northcentral Nigeria
  5. 15025
    “…In literature, TCR has been seen during ocular surgeries, Lefort fractures, and craniofacial surgeries. However, the prevalence of the TCR has not been studied in zygomatic complex fractures . …”
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    Evaluation of Trigeminocardiac Reflex in Patients Undergoing Elevation of Zygomatic Fractures
  6. 15026
    por Sahoo, Anik, Baitalik, Sujoy
    Publicado 2022
    “…Conducting very detailed sensing studies by varying the concentration of the analytes within a wide domain is often very time-consuming, laborious, and expensive. To decrease the time and expenses of the investigations, soft computing approaches such as artificial neural networks (ANNs), fuzzy logic, or adaptive neuro-fuzzy inference system (ANFIS) can be recommended to predict the experimental spectral data. …”
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    Fuzzy Logic, Artificial Neural Network, and Adaptive Neuro-Fuzzy Inference Methodology for Soft Computation and Modeling of Ion Sensing Data of a Terpyridyl-Imidazole Based Bifunctional Receptor
  7. 15027
    “…Of all the teachers, phono trauma tends to be more among females who were primary school teachers, currently teaching distance learning, and those who perceived distance learning to be laborious.…”
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    The Effect of Online Teaching on Vocal Health Among Saudi Teachers During COVID-19 Pandemic
  8. 15028
    “…However, correlating mesoscopic and nanoscopic scales in the same cell, cell population or brain region is a problematic, laborious and technically demanding task. Here we present an effective method for the 3D reconstruction of labeled subcellular structures at the ultrastructural level, after single-neuron labeling in fixed tissue. …”
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    Single-Neuron Labeling in Fixed Tissue and Targeted Volume Electron Microscopy
  9. 15029
    “…Whenever the funds had to be reworked, the funds that were asked for were released. …”
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    Predicting Timelines in Healthcare Infrastructure Projects: Learnings From an Apex Tertiary Care Teaching Hospital in North India
  10. 15030
    “…Due to their ability to self-aggregate in a carrier-free, biodegradable form, no further laborious immobilization steps or additional reagents are needed. …”
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    Construction and characterization of BsGDH-CatIB variants and application as robust and highly active redox cofactor regeneration module for biocatalysis
  11. 15031
    “…However, clinical application remains challenging because of methodologic limitations and laborious process involved in spatial analysis of TIL distribution in whole-slide images (WSI). …”
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    Artificial Intelligence–Powered Spatial Analysis of Tumor-Infiltrating Lymphocytes as Complementary Biomarker for Immune Checkpoint Inhibition in Non–Small-Cell Lung Cancer
  12. 15032
    “…It results in repair and reworks that amount to a considerable loss of money and time. …”
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    Improvement in Durability and Mechanical Performance of Concrete Exposed to Aggressive Environments by Using Polymer
  13. 15033
    “…This work presents a synchronized multi-robot WAAM and NDE cell aiming to achieve (1) defect detection in-process, (2) enable possible in-process repair and (3) prevent costly scrappage or rework of completed defective builds. The deployment of the NDE during a deposition process is achieved through real-time position control of robots based on sensor input. …”
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    Collaborative Robotic Wire + Arc Additive Manufacture and Sensor-Enabled In-Process Ultrasonic Non-Destructive Evaluation
  14. 15034
    “…BACKGROUND: Addressing the laborious nature of traditional biological experiments by using an efficient computational approach to analyze RNA-binding proteins (RBPs) binding sites has always been a challenging task. …”
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    DeepPN: a deep parallel neural network based on convolutional neural network and graph convolutional network for predicting RNA-protein binding sites
  15. 15035
    “…All of this requires serological assays that can process a large number of samples in a highly standardized format. Albeit being laborious, time-consuming, and limited in throughput, the classical plaque reduction neutralization test (PRNT) is still considered the gold standard for the detection and quantification of nAbs due to its sensitivity and specificity. …”
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    A High-Throughput Yellow Fever Neutralization Assay
  16. 15036
    “…A combination of national registers and local health records can be used to collect data relevant for cognitive screening; today, the process is laborious, but it could be improved in the future with refined search algorithms and electronic data.…”
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    Cognitive Performance at Time of AD Diagnosis: A Clinically Augmented Register-Based Study
  17. 15037
    “…Conventional vaccine synthesis techniques are often very laborious and challenging. With the advancement of bioinformatics and its application in immunology, it is now more convenient to design multi-epitope vaccines comprising predicted immuno-dominant epitopes of multiple antigenic proteins. …”
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    In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani
  18. 15038
    “…Despite the development of RNA-Seq library preparation methods and sequencing platforms in the last decade, RNA extraction remains the most laborious and costly step in RNA-Seq of tissue samples of various organisms. …”
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    DeLTa-Seq: direct-lysate targeted RNA-Seq from crude tissue lysate
  19. 15039
    “…The current manual survey method of rice diseases and pests is time-consuming, laborious, highly subjective and difficult to trace historical data. …”
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    An intelligent monitoring system of diseases and pests on rice canopy
  20. 15040
    “…The ROP of proline NCA (ProNCA) for the synthesis of poly-(L)-proline (PLP) is particularly challenging due to the premature product precipitation as polyproline type I helices, leading to slow reactions for up to one week, poor control of the molar mass and laborious workup. Here, we report the unexpected water-assisted controlled ROP of ProNCA, which affords well-defined PLP as polyproline II helices in 2–5 minutes and almost-quantitative yields. …”
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    Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride
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