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  1. 15201
    “…The proposed methods by the CLSI or the EUCAST are both laborious for the everyday routine. There are alternative applications which propose the use of an inoculum, consisting of a conidia-mycelium mixture or even plain mycelia, as well as the use of resazurin in order to facilitate the reading. …”
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    Comparison of Four Methods for the in vitro Susceptibility Testing of Dermatophytes
  2. 15202
    “…Current metabolite quantification methods use laborious, technically highly complex, and expensive liquid chromatography‐tandem mass spectro‐metry, which is available only in selected laboratories worldwide. …”
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    Condensation of delta‐1‐piperideine‐6‐carboxylate with ortho‐aminobenzaldehyde allows its simple, fast, and inexpensive quantification in the urine of patients with antiquitin deficiency
  3. 15203
    “…Most existing sleep/wake identification algorithms are based on activity only and are trained on expensive and laboriously annotated polysomnography (PSG). Heart rate can also be reflective of sleep/wake transitions, which has motivated its investigation herein in an unsupervised algorithm. …”
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    Wearable Device Heart Rate and Activity Data in an Unsupervised Approach to Personalized Sleep Monitoring: Algorithm Validation
  4. 15204
    “…BACKGROUND: Cardio myoblast generation from conventional approaches is laborious and time-consuming. We present a bioelectronics on-a-chip for stimulating cells cardio myoblast proliferation during culture. …”
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    Bioelectronics-on-a-chip for cardio myoblast proliferation enhancement using electric field stimulation
  5. 15205
    por Kim, Hyeran, Choi, Jisun, Won, Kang-Hee
    Publicado 2020
    “…The rapid and convincing selection of guide RNA against a target genome reduces the laborious efforts for tissue culture and facilitates effective gene editing for pepper improvement.…”
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    A stable DNA-free screening system for CRISPR/RNPs-mediated gene editing in hot and sweet cultivars of Capsicum annuum
  6. 15206
    “…By automatically associating relevant Gene Ontology terms, PALMER facilitates biological interpretation of novel findings without laborious downstream analyses. PALMER also allows researchers to utilize prior biological knowledge about known gene-pathway relationships to guide identification of gene–gene associations. …”
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    PALMER: improving pathway annotation based on the biomedical literature mining with a constrained latent block model
  7. 15207
    “…We intend to publish the study results in a journal or conference presentations. OPEN SCIENCE FRA MEWORK (OSF) REGISTRATION NUMBER: August 27, 2020. osf.io/7nh3k (https://osf.io/7nh3k).…”
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    Huang Lian for ulcerative colitis: A protocol of systematic review and meta-analysis of randomized clinical trials
  8. 15208
    “…Moreover, finding novel targets involving compound screening is both laborious and is an expensive process in itself followed by equally tedious Food and Drug Administration (FDA) approval exercise. …”
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    Ofloxacin as a Disruptor of Actin Aggresome “Hirano Bodies”: A Potential Repurposed Drug for the Treatment of Neurodegenerative Diseases
  9. 15209
    “…The established reverse transcription LAMP (RT-LAMP) assay detects SARS-CoV-2 directly from pharyngeal swab samples without previous time-consuming and laborious RNA extraction. The assay is sensitive and highly specific for SARS-CoV-2 detection, showing no cross reactivity when tested on 20 other respiratory pathogens. …”
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    Rapid point-of-care detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP)
  10. 15210
    “…Although rice protoplasts can be isolated from germinated seedlings or cell suspension culture, preparation of those donor tissues can be inefficient, time-consuming, and laborious. Additionally, the lengthy process of protoplast isolation and transfection needs to be completed in a single day. …”
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    Efficient isolation of protoplasts from rice calli with pause points and its application in transient gene expression and genome editing assays
  11. 15211
    “…CONCLUSION: Targeted NGS with haplotyping analysis circumvents the laborious process of multiplex PCR and is more likely to ensure diagnostic accuracy. …”
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    Preimplantation Genetic Testing for a Chinese Family With X-Linked Lymphoproliferative Syndrome Type 1
  12. 15212
    “…MOTIVATION: De novo assembly of reference-quality genomes used to require enormously laborious tasks. In particular, it is extremely time-consuming to build genome markers for ordering assembled contigs along chromosomes; thus, they are only available for well-established model organisms. …”
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    HiC-Hiker: a probabilistic model to determine contig orientation in chromosome-length scaffolds with Hi-C
  13. 15213
    “…This study reveals for the first time the paleoenvironmental context of exceptionally enriched pyrite-δ(34)S and -δ(56)Fe in bioturbated, storm-reworked mudstones of an early Ordovician storm-dominated delta (Tremadocian Beach Formation, Bell Island Group, Newfoundland). …”
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    Exceptional sulfur and iron isotope enrichment in millimetre-sized, early Palaeozoic animal burrows
  14. 15214
    “…Automated phenotyping methods that leverage electronic health records (EHRs) represent a fundamentally new approach cohort identification without current laborious and ungeneralizable generation of phenotyping algorithms. …”
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    Comparative analysis, applications, and interpretation of electronic health record-based stroke phenotyping methods
  15. 15215
    “…Conventionally, categorical scoring systems have been widely used to study flowering patterns, which are laborious and subjective to apply. The goal of this study was to develop a deep learning-based approach to characterize flowering patterns for cotton plants that flower progressively over several weeks, with flowers distributed across much of the plant. …”
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    DeepFlower: a deep learning-based approach to characterize flowering patterns of cotton plants in the field
  16. 15216
    “…As many inpatient hospitals reworked patient flow during the COVID-19 surge, we hypothesized that HIV testing in PWUD would decrease. …”
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    Increased HIV testing in people who use drugs hospitalized in the first wave of the COVID-19 pandemic
  17. 15217
    “…OBJECTIVES: The standard RT-PCR assay for coronavirus disease 2019 (COVID-19) is laborious and time-consuming, limiting testing availability. …”
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    Multicenter evaluation of the Panbio™ COVID-19 rapid antigen-detection test for the diagnosis of SARS-CoV-2 infection
  18. 15218
    “…Unmanned aircraft systems (UAS), also known as drones, are commonly used to photograph animals in remote locations; however, counting animals in images is a laborious task. Crowd-sourcing can reduce the time required to conduct these censuses considerably, but must first be validated against expert counts to measure sources of error. …”
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    Accuracy and precision of citizen scientist animal counts from drone imagery
  19. 15219
    por Elghafari, Anas, Finkelstein, Joseph
    Publicado 2021
    “…This is usually a time-consuming and laborious process. OBJECTIVE: The objectives of this work were to develop and evaluate a generalized pipeline that can automatically identify common outcomes specific to any given disease by finding, downloading, and analyzing data of previous clinical trials relevant to that disease. …”
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    Automated Identification of Common Disease-Specific Outcomes for Comparative Effectiveness Research Using ClinicalTrials.gov: Algorithm Development and Validation Study
  20. 15220
    “…To reduce the risk of anthropogenic pandemics, structures for the governance of biotechnology and life science research with dual-use potential need to be reworked. Scientists outside of the pathogen research community, for instance those who work on viral vectors or oncolytic viruses, need to become more aware of the dual-use risks associated with their research. …”
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    Biosecurity risks associated with vaccine platform technologies
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