“…However, existing severity scoring systems or algorithms used in intensive care units (ICUs) often rely on laborious manual collection of complex variables and lack sufficient validation in diverse clinical environments, thus limiting their practical applicability. …”
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“…Serial block face scanning electron microscopy (SBF-SEM) offers non-laborious, automated imaging in 3D of up to ~ 1 mm(3) large biological objects at nanometer-scale resolution. …”
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“…Bulk δ(13)C of leaves that had fully developed prior to water deficit were the best proxies for storage root biomass (r = - 0.62, r = - 0.70) and transpiration efficiency (r = - 0.68, r = - 0.58) for the local and improved variety respectively, making laborious extractions redundant. Results obtained from the youngest fully developed leaf, commonly used as a diagnostic leaf, were complicated by remobilized assimilates in the improved variety, making them less suitable for carbon isotope analysis. …”
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“…The conventional methods to find these specific TFs and their interactivities are slow and laborious. In this study, a novel efficient method is proposed to detect the TFs and their interactivities that regulate yeast genes that respond to any specific environment change. …”
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“…However, the recovery of microgram amounts of DNA needed for some assays requires sorting of millions of chromosomes which is laborious and time consuming. Yet, many genomic applications such as development of genetic maps or physical mapping do not require large DNA fragments. …”
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“…BACKGROUND: Current techniques of screening bacterial artificial chromosome (BAC) libraries for molecular markers during the construction of physical maps are slow, laborious and often assign multiple BAC contigs to a single locus on a genetic map. …”
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“…This generally resulted in groups of assays with different annealing temperatures that required the use of multiple thermal cyclers or multiple passes in a single thermal cycler making diagnostic testing time-consuming, laborious and expensive. These factors have severely hampered diagnostic testing services, leaving many families without an answer for the exact cause of a familial genetic disease. …”
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“…BACKGROUND: Bioprocess development of recombinant proteins is time consuming and laborious as many factors influence the accumulation of the product in the soluble and active form. …”
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“…BACKGROUND: To date, the detection of live microorganisms present in the environment or involved in infections is carried out by enumeration of colony forming units on agar plates, which is time consuming, laborious and limited to readily cultivable microorganisms. …”
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“…Behavioural effects of apremilast, relative to rolipram, were assessed in naïve DBA/1 mice using an automated activity monitor (LABORAS). RESULTS: Apremilast dose dependently inhibited spontaneous release of TNFα from human rheumatoid synovial membrane cultures. …”
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“…PREVIOUS PUBLICATION: This article is a reworked version of the study 'Er inntektsforskjeller dødelige?' …”
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“…Current scanning methods used for the detection of germline sequence variants are laborious as they require post-PCR manipulation. High resolution melting (HRM) is a cost-effective rapid screening strategy, which readily detects heterozygous variants by melting curve analysis of PCR products. …”
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“…Current cell culture practices are dependent upon human operators and remain laborious and highly subjective, resulting in large variations and inconsistent outcomes, especially when using visual assessments of cell confluency to determine the appropriate time to subculture cells. …”
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“…Simulation with policy model demonstrates a reduction of the rework problem. CONCLUSIONS/SIGNIFICANCE: Patterns of threats to data quality at the two sites were similar to the threats reported in the literature for American sites. …”
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“…Classical experimental approaches are laborious and time-consuming, and therefore computational methods for generating epitope candidates have been actively studied. …”
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“…Vast accumulations of fine-grained “legacy” sediments that blanket the regional valley-bottom Piedmont landscape now are being reworked from stream banks, significantly impairing the ecological health of downstream water bodies, most notably the Chesapeake Bay. …”
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“…The traditional methods of measuring lignin syringyl/guaiacyl (S/G) ratio can be laborious, involve hazardous reagents, and/or be destructive. …”
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“…BACKGROUND AND AIM: Arterial carbon dioxide tension (PaCO(2)) is considered the gold standard for scrupulous monitoring in pediatric intensive care unit (PICU), but it is invasive, laborious, expensive, and intermittent. The study aims to explore when we can use end-tidal carbon dioxide tension (P(ET)CO(2)) as a reliable, continuous, and noninvasive monitor of arterial CO(2) MATERIALS AND METHODS: Concurrent P(ET)CO(2), fraction of inspired oxygen, PaCO(2), and arterial oxygen tension values of clinically stable children on mechanical ventilation were recorded. …”
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“…CONCLUSIONS: The HMM-based method along with the conventional pattern matching approach can contribute to reducing costly and laborious wet-lab experiments to perform functional analysis on a given set of potential G-quadruplexes of interest. …”
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“…BACKGROUND: An accessory to modern developing economies includes a shift from traditional, laborious lifestyles and cuisine to more sedentary careers, recreation and convenience-based foodstuffs. …”
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