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  1. 15841
    “…We believe that the work presented here can contribute greatly to the tremendous task of automating the important yet labor-intensive biocuration effort.…”
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    Online Artículo Texto
    Automatic categorization of diverse experimental information in the bioscience literature
  2. 15842
    “…However, conventional TMA construction is laborious, time-consuming and imprecise. Next-generation tissue microarrays (ngTMA) combine histological expertise with digital pathology and automated tissue microarraying. …”
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    Online Artículo Texto
    Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types
  3. 15843
    “…The state-of-the-art methods required laborious adjustments of parameter values to achieve these results. …”
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    Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition
  4. 15844
    “…Furthermore, 5-loci MLVA was a less laborious method and easier to interpret than XbaI-PFGE. …”
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    Characterization of Salmonella Typhimurium isolates from domestically acquired infections in Finland by phage typing, antimicrobial susceptibility testing, PFGE and MLVA
  5. 15845
    por Chen, Fang, He, Jing, Zhang, Jianqi, Chen, Gary K., Thomas, Venetta, Ambrosone, Christine B., Bandera, Elisa V., Berndt, Sonja I., Bernstein, Leslie, Blot, William J., Cai, Qiuyin, Carpten, John, Casey, Graham, Chanock, Stephen J., Cheng, Iona, Chu, Lisa, Deming, Sandra L., Driver, W. Ryan, Goodman, Phyllis, Hayes, Richard B., Hennis, Anselm J. M., Hsing, Ann W., Hu, Jennifer J., Ingles, Sue A., John, Esther M., Kittles, Rick A., Kolb, Suzanne, Leske, M. Cristina, Millikan, Robert C., Monroe, Kristine R., Murphy, Adam, Nemesure, Barbara, Neslund-Dudas, Christine, Nyante, Sarah, Ostrander, Elaine A, Press, Michael F., Rodriguez-Gil, Jorge L., Rybicki, Ben A., Schumacher, Fredrick, Stanford, Janet L., Signorello, Lisa B., Strom, Sara S., Stevens, Victoria, Van Den Berg, David, Wang, Zhaoming, Witte, John S., Wu, Suh-Yuh, Yamamura, Yuko, Zheng, Wei, Ziegler, Regina G., Stram, Alexander H., Kolonel, Laurence N., Marchand, Loïc Le, Henderson, Brian E., Haiman, Christopher A., Stram, Daniel O.
    Publicado 2015
    “…We conclude that today's GWAS data will remain useful in the future for causal variant prediction, but that finding the causal variants that need to be predicted may be extremely laborious.…”
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    Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults
  6. 15846
    “…Accurate interpretation of DNA banding patterns from electrophoretic images can be laborious and error prone when a large number of bands are interrogated manually. …”
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    Automatic DNA Diagnosis for 1D Gel Electrophoresis Images using Bio-image Processing Technique
  7. 15847
    “…However, due to the laborious and potentially error prone nature of this measurement technique, an alternative method is desirable. …”
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    Validation of an automated colony counting system for group A Streptococcus
  8. 15848
    “…However, RSA remains a laborious process, involving heparin, Percoll gradient, and sorbitol treatments to obtain rings in the 0–3 h window. …”
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    Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity
  9. 15849
    “…However, narrowing down further towards culprit disease genes usually entails laborious seeking of gene-phenotype relationships, consulting numerous separate databases. …”
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    Online Artículo Texto
    VarElect: the phenotype-based variation prioritizer of the GeneCards Suite
  10. 15850
    “…However, the production of stable transformants can be slow and laborious with no guarantee of success. Furthermore, transgenic plants overexpressing a TF of interest can present pleiotropic phenotypes and/or result in a high number of indirect gene expression changes. …”
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    Infiltration-RNAseq: transcriptome profiling of Agrobacterium-mediated infiltration of transcription factors to discover gene function and expression networks in plants
  11. 15851
    “…Seven cases received LAA closure using Lefort and 21 using LAmbre based on the 3D TEE and radiography. …”
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    Roles of real-time three-dimensional transesophageal echocardiography in peri-operation of transcatheter left atrial appendage closure
  12. 15852
    “…Therefore, expensive and laborious “one-size-fits-all” processes are still widely used. …”
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    High-throughput analysis of chemical components and theoretical ethanol yield of dedicated bioenergy sorghum using dual-optimized partial least squares calibration models
  13. 15853
    “…However, the analysis method is laborious, and future work is needed for more automation to make the method more easily applicable in a clinical setting.…”
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    Online Artículo Texto
    Calculation of left ventricular volumes and ejection fraction from dynamic cardiac-gated (15)O-water PET/CT: 5D-PET
  14. 15854
    “…However, searching databases is laborious and time-consuming, as syntax of search strategies are database specific. …”
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    Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study
  15. 15855
    “…Targeted purification of these unknown candidates will significantly reduce purification time and labor. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13007-017-0258-3) contains supplementary material, which is available to authorized users.…”
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    High-throughput detection of antioxidants in mulberry fruit using correlations between high-resolution mass and activity profiles of chromatographic fractions
  16. 15856
    “…Although the manual counting of both types of grains is the simplest and most sensitive approach, it is a laborious and time-demanding process. In this regard, novel image-based approaches can assist in the objective, accurate and cost-effective phenotyping of this trait. …”
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    A new image-based tool for the high throughput phenotyping of pollen viability: evaluation of inter- and intra-cultivar diversity in grapevine
  17. 15857
    “…However, identifying these molecular biomarkers remains a laborious and challenging task. Next-generation sequencing of patients and preclinical models have increasingly led to the identification of novel gene-mutation-drug relations, and these results have been reported and published in the scientific literature. …”
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    Deep learning of mutation-gene-drug relations from the literature
  18. 15858
    “…However, trees were permanently pruned and debarked by local people. Harvesting of barks mostly contributed to the decline of the species populations. …”
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    Use patterns, use values and management of Afzelia africana Sm. in Burkina Faso: implications for species domestication and sustainable conservation
  19. 15859
    “…Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice (GCP) and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise. Therefore, we developed a simple auditing process (a screening audit) and evaluated its feasibility and effectiveness. …”
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    ‘Screening audit’ as a quality assurance tool in good clinical practice compliant research environments
  20. 15860
    “…Classical methods of tissue fixation and embedding prior to 2D microscopy of sections is both laborious and susceptible to artefacts that can skew the values obtained. …”
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    Investigating the microstructure of plant leaves in 3D with lab-based X-ray computed tomography
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