“…Through reinfection studies in B6.Il10 (-/-) mice and drug (AmBisome(®)) treatment of B6 mice, we also show the dependence of monocyte activation on parasite load. …”
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“…SSG/PM was the main treatment regimen from 2001–2018, used in 68.7% of primary and 70.9% of relapse VL cases; AmBisome was introduced in 2013, received by 22.5% of primary VL and 32.6% of VL relapse cases from 2013–2018. …”
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“…</span></span></span></p> <p><span><span><span>Au cours des derniers mois, cinq binômes de scientifiques du CERN ont mené l'enquête.…”
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“…Herein, we will illustrate a few challenges and solutions of these efforts using novel methods for synthesizing different contrast modality images, auto-segmentation, and image reconstruction with examples from lung CT as well as abdome, pelvis, and head and neck MRI. The imaging community must embrace the need for quantitative CT and MRI metrics beyond lesion size measurement. …”
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“…METHODS/DESIGN: The FEATHER (FEbuxostat versus placebo rAndomized controlled Trial regarding reduced renal function in patients with Hyperuricemia complicated by chRonic kidney disease stage 3) study is a prospective, multicenter, double-blind, randomized, placebo-controlled trial of febuxostat—a novel, nonpurine, selective, xanthine oxidase inhibitor. …”
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“…Mice treated with KALSOME™10 showed elevated levels of IFNγ and suppressed IL-10 secretion from both CD4(+) and CD8(+) subsets of T cells, as well as from culture supernatants of splenocytes, compared to that of normal, AmB and AmBisome treated animals. CONCLUSIONS: Treatment of infected mice with 7.5 mg/kg double dose of KALSOME™10 was safe and effective in clearing the parasites from the sites of infection. …”
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“…BACKGROUND: Amphotericin B (AmB) as a liposomal formulation of AmBisome is the first line of treatment for the disease, visceral leishmaniasis, caused by the parasite Leishmania donovani. …”
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“…To investigate potential prediction of VL related complications, serum samples of 32 PKDL, 10 RVL, 07 TF, and 38 cured VL from a single dose AmBisome trial were analyzed. Of this second panel, all patients were monitored for 5 years and sera were collected at four time points (Baseline then 1, 6, and 12 months after treatment). …”
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“…Outcome rates were compared with two-tailed Fisher exact test using fisher.test function in R software. 95% confidence intervals for proportions were calculated using the Clopper-Pearson method with binom.test function in R. The groups of patients with poor vs. good and fair quality embryos were compared by age, body mass index(BMI), number of oocytes, female and male main diagnosis, cycle type, controlled ovarian stimulation (COS) protocol, the starting day of gonadotropin administration, the starting dose of gonadotropins, the total dose of gonadotropins, the total number of days of gonadotropins administration, the starting day of gonadotropin-releasing hormone (GnRH) agonist administration, the total number of ampoules of GnRH-agonist used, day of the trigger of ovulation administration and the type of the trigger of ovulation using the Student’s t-test for interval variables and with the chi-square test for nominal variables. …”
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“…Two types of orthoses used in treating developmental dysplasia of the hip (Tübinger splint, Otto Bock; hip flexion abduction orthosis (Superior orthosis) according to Mittelmeier-Graf, AIDAMED e.K (Kreuz et al., 2012; Mittelmeier et al., 1998; Schmitz et al., 1999), constructions differ, were used. …”
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“…Apesar de no caso citado ter sido atribuída ao SARS-COV2, não se descarta o acometimento concomitante com Herpes e Chikungunya, o que pode ter contribuído para uma maior gravidade e complicações. …”
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“…Drug control was 10 mg/kg AmBisome i.v. RESULTS: The MIC for VT-1598 against AF 204305 was 0.25 μg/mL. …”
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“…Liposomes with AmB intercalated into the lipid membrane (AmB-LLs; available commercially as AmBisome) have severalfold-reduced toxicity compared to that of detergent-solubilized drug. …”
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“…To address this, we standardized a nebulization method for effectively delivering liposomal amphotericin B (AmBisome®, AmBi) into lungs of Aspergillus fumigatus-infected mice. …”
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“…No décimo quarto dia após a vacinação evoluiu com petéquias, sangramento gengival e equimoses em membro superior direito e região anterior do abdome. Negava sintomas respiratórios, gastrointestinais ou outras queixas. …”
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“…Em propedêutica complementar apresentou esplenomegalia leve, visualizada em tomografia computadorizada de abdome. Sem demais alterações. Provas inflamatórias elevadas assim como desidrogenase láctica e hiperferritinemia importante (>400000) com provas de hemólise negativas. …”
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“…Evidências epidemiológicas sugerem que a infecção por SARS-CoV-2 apresenta menor gravidade e melhor desfecho clínico em crianças. Por outro lado, complicações respiratórias agudas e falência de múltiplos órgãos podem ocorrer. …”
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“…Questiona-se a possibilidade da desregulação do sistema imunológico secundária a infecção grave por coronavírus (COVID 19) ter sido um fator facilitador para apresentação da LV clinicamente manifesta no caso descrito. …”
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