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  1. 6021
    por Beca, Francisco, Beck, Andrew H.
    Publicado 2016
    “…In a Perspective, Francisco Beca and Andrew Beck discuss Charles Swanton and colleagues' accompanying Research Article on somatic mutations in patients with inflammatory breast cancer treated in a Phase II clinical trial.…”
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    Precision Cancer Diagnostics: Tracking Genomic Evolution in Clinical Trials
  2. 6022
    “…ABA triblock polyesters are synthesized using a commercially available chromium salen catalyst, in one pot, from monomer mixtures comprising epoxide, anhydride and lactone. The catalysis is highly selective and applies a single catalyst in two distinct pathways. …”
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    Selective Polymerization Catalysis from Monomer Mixtures: Using a Commercial Cr‐Salen Catalyst To Access ABA Block Polyesters
  3. 6023
    “…PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with various substrate specificities. …”
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    Online Artículo Texto
    Human Paraoxonase-2 (PON2): Protein Functions and Modulation
  4. 6024
    “…Using a copper(II)‐BOX catalytic system, bridged bicyclic lactones are obtained in very high yields (up to 99 % yield) and enantioselectivities (up to 99 % ee) from diversely substituted 2‐pyrones and acyclic enol ethers. …”
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    Diastereo‐ and Enantioselective Inverse‐Electron‐Demand Diels–Alder Cycloaddition between 2‐Pyrones and Acyclic Enol Ethers
  5. 6025
    “…Isothiourea-catalyzed annulations between 2-acyl benzazoles and α,β-unsaturated acyl ammonium intermediates are selectively tuned to form either lactam or lactone heterocycles in good yields (up to 95%) and high ee (up to 99%) using benzothiazole or benzoxazole derivatives, respectively. …”
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    Non-bonding 1,5-S···O interactions govern chemo- and enantioselectivity in isothiourea-catalyzed annulations of benzazoles
  6. 6026
    “…The glucosidic derivative of 8-deoxylactucin constituted over 85 % of the total sesquiterpene lactone content in the long-term cultured hairy roots of chicory. …”
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    Long-Term Cultured Hairy Roots of Chicory—A Rich Source of Hydroxycinnamates and 8-Deoxylactucin Glucoside
  7. 6027
    “…Considering local athletes, finishers from Canton of Uri and Glarus were the fastest and those from Canton of Geneva and Basel the slowest. …”
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    The Russians Are the Fastest in Marathon Cross-Country Skiing: The “Engadin Ski Marathon”
  8. 6028
    “…Medicinal plants play a crucial role in traditional medicine and in the maintenance of human health worldwide. Sesquiterpene lactones represent an interesting group of plant-derived compounds that are currently being tested as lead drugs in cancer clinical trials. …”
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    Differential Growth Inhibitory Effects of Highly Oxygenated Guaianolides Isolated from the Middle Eastern Indigenous Plant Achillea falcata in HCT-116 Colorectal Cancer Cells
  9. 6029
    “…Additional vaccinations were available in 13 cantons (e.g., tick-borne encephalitis or hepatitis A, B, or A and B). …”
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    The Role of Community Pharmacists in Travel Health and Vaccination in Switzerland
  10. 6030
    “…Both bioactivities are related to an α-methylene-γ-lactone moiety and an ester group on carbon C-8 in the sesquiterpene lactone (SL) structure. …”
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    Expanding the Study of the Cytotoxicity of Incomptines A and B against Leukemia Cells
  11. 6031
    “…For each AHL-producing strain, we found at least four different AHLs, corresponding to N-hexanoyl-dl-homoserine lactone (C(6)), N-(3-oxodecanoyl)-l-homoserine lactone (3OC(10)), N-(3-oxododecanoyl)-l-homoserine lactone (3OC(12)), and N-(3-oxotetradecanoyl)-l-homoserine lactone (3OC(14)). …”
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    Detection, Characterization, and Biological Effect of Quorum-Sensing Signaling Molecules in Peanut-Nodulating Bradyrhizobia
  12. 6032
    “…GP consultations, total numbers and rates, and the relative costs reimbursed (TARMED tariff values) in the Swiss federal states, cantons, which already introduced a DRG-like system before 2012 (AP-DRG), were compared to the GP consultations and costs reimbursed in the other cantons (DRG-naive). …”
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    Effects of a DRG-based hospital reimbursement on the health care utilization and costs in Swiss primary care: A retrospective “quasi-experimental” analysis
  13. 6033
    “…When 23S,25(OH)(2)D3 was administered to Cyp24a1 KO rats, neither 23,25,26(OH)(3)D3 nor 25(OH)D3-26,23-lactone was observed. However, when 23S,25R,26(OH)(3)D3 was administered to Cyp24a1 KO rats, plasma 25(OH)D3-26,23-lactone was detected. …”
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    Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system
  14. 6034
    “…Many Gram-negative bacteria respond to N-acyl-L-homoserine lactone (AHL) signals to coordinate phenotypes such as biofilm formation and virulence factor production. …”
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    Engineering Quorum Quenching Acylases with Improved Kinetic and Biochemical Properties
  15. 6035
    “…BACKGROUND: Sesquiterpene lactones are characteristic metabolites of Asteraceae (or Compositae) which often display potent bioactivities and are sequestered in specialized organs such as laticifers, resin ducts, and trichomes. …”
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    Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes
  16. 6036
    “…Cantonal variations remained substantial but unexplained by supply or demand. …”
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    Comparing potentially avoidable hospitalization rates related to ambulatory care sensitive conditions in Switzerland: the need to refine the definition of health conditions and to adjust for population health status
  17. 6037
    “…An LC-MS/MS analysis revealed that StFRB508 produced six types of AHLs, with the most important AHL being N-(3-hydroxyhexanoyl)-l-homoserine lactone (3-OH-C6-HSL). PhzI mainly catalyzed the biosynthesis of 3-OH-C6-HSL, while AurI and CsaI catalyzed that of N-hexanoyl-l-homoserine lactone and N-(3-oxohexanoyl)-l-homoserine lactone, respectively. …”
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    Complete Genome Sequence of Pseudomonas chlororaphis subsp. aurantiaca Reveals a Triplicate Quorum-Sensing Mechanism for Regulation of Phenazine Production
  18. 6038
    “…Hafnia alvei H4 is a bacterium subject to regulation by a N-acyl-l-homoserine lactone (AHL)-mediated quorum sensing system and is closely related to the corruption of instant sea cucumber. …”
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    Effect of the luxI/R gene on AHL-signaling molecules and QS regulatory mechanism in Hafnia alvei H4
  19. 6039
    “…No evidence was provided for a causal link of temperature-sensitive sterility with sleep disturbance under high temperature in infertile females born from females of Canton-S strain and males of Harwich strain. However, sensitivity of sleep of these females to high temperature differed from that in fertile females born from females of Harwich strain and males of Canton-S strain and in males of either cross. …”
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    Association between the Effects of High Temperature on Fertility and Sleep in Female Intra-Specific Hybrids of Drosophila melanogaster
  20. 6040
    “…The title terpene, C(30)H(46)O(3), is a 28,13β-lactone of oleanolic acid prepared with bis­muth trifluoro­methane­sulfonate (OTf), Bi(OTf)(3)·xH(2)O. …”
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    3-Oxo-18α-olean-28,13β-olide
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