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  1. 6061
    “…The anti-parasitic family of macrocyclic lactones (ML) (divided in two subfamilies: avermectins and milbemycins) was previously described as having activity against mycobacteria, including Mycobacterium tuberculosis, Mycobacterium ulcerans, and Mycobacterium marinum, among others. …”
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    Repurposing Avermectins and Milbemycins against Mycobacteroides abscessus and Other Nontuberculous Mycobacteria
  2. 6062
    “…The fermentation products predominantly consist of the diacetylated lactonic form that coexists with the open-chain acidic form. …”
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    Structure–Activity Relationship Assessment of Sophorolipid Ester Derivatives against Model Bacteria Strains
  3. 6063
    “…Among the identified compounds, benzyl salicylate, terpinolene, C12 massoia lactone, sabinene, benzyl benzoate, methyl eugenol, and C10 massoia lactone exhibited the strong larvicidal activity. …”
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    Development of cellulose nanocrystal-stabilized Pickering emulsions of massoia and nutmeg essential oils for the control of Aedes albopictus
  4. 6064
    por Francetic, Igor
    Publicado 2021
    “…Notably, the law introduced stronger coordination between Federal and Cantonal authorities, better management tools and international cooperation. …”
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    Bad law or implementation flaws? Lessons from the implementation of the new law on epidemics during the response to the first wave of COVID-19 in Switzerland
  5. 6065
    “…We propose that bivalent metal cations also promote the reaction nonenzymatically by stabilizing a short-lived bicyclic intermediate on the lactone isomerization reaction. An analysis of the reaction kinetics showed that Cc XylC complexed with Fe(2+) can speed up the hydrolysis of d-xylono-1,4-lactone by 100-fold and that of d-glucono-1,5-lactone by 10-fold as compared to the nonenzymatic reaction. …”
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    Xylonolactonase from Caulobacter crescentus Is a Mononuclear Nonheme Iron Hydrolase
  6. 6066
    “…We report here the first crystal structure of an 8-epi-salvinorin or derivative: the title compound, 2b. The lactone adopts a boat conformation with the furan equatorial. …”
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    8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor
  7. 6067
    “…Ellagic acid, a δ-lactone with ionisable phenolic residues, is an efficient time-dependent inhibitor of the serine β-lactamase enzyme CTX-M-15. …”
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    Both the mono- and di-anions of ellagic acid are effective inhibitors of the serine β-lactamase CTX-M-15
  8. 6068
    “…OBJECTIVES: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. …”
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    Computational Optimization of Bioanalytical Parameters for the Evaluation of the Toxicity of the Phytomarker 1,4 Napthoquinone and its Metabolite 1,2,4-trihydroxynapththalene
  9. 6069
    “…The larval periods for larvae on the diets containing γ-chloro- and γ-bromo-δ-lactone were 33 and 41 days, respectively. The larval developmental time and body weight gain were not significantly influenced by lower doses of the compounds, with the exception of γ-bromo-δ-lactone. …”
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    Effects of halolactones with strong feeding-deterrent activity on the growth and development of larvae of the lesser mealworm, Alphitobius diaperinus (Coleoptera: Tenebrionidae)
  10. 6070
    “…Knowledge of buprestid chemical ecology is sparse but the appearance of the invasive pest Agrilus planipennis Fairmaire in North America has provided the impetus to study in detail the semiochemistry and ecology of this important buprestid. The macrocyclic lactone (3Z)-12-dodecenolide [(3Z)-lactone] is identified as a key antennally-active compound that is produced by females and attracts males. …”
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    Semiochemical and Communication Ecology of the Emerald Ash Borer, Agrilus planipennis (Coleoptera: Buprestidae)
  11. 6071
    “…The study has revealed important variations among cantons but also a spatial clustering, mainly in the Amazon region of the country. …”
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    “The devil is in the detail”: geographical inequalities of femicides in Ecuador
  12. 6072
    “…The furan­ose ring approximates an envelope conformation due to the α,β-unsaturated lactone functionality. The asymmetric unit contains two independent mol­ecules with almost identical geometries.…”
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    (R)-3,4,5-Tride­oxy-5,6-didehydro-1,2-O-(2,2,2-trichloro­ethyl­idene)-α-d-gluco­furan­ose-6,3-carbolactone: a new derivative of α-chloralose
  13. 6073
    “…Although the copolymerizations of l-lactide (LA) with seven- or six-membered ring lactones have been extensively studied, the copolymerizations of LA with four-membered ring lactones have scarcely been reported. …”
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    Synthesis and Biodegradation of Poly(l-lactide-co-β-propiolactone)
  14. 6074
    “…We recently reported that carboxylic acids can be oxidized to lactone products by potassium persulfate and catalytic copper acetate. …”
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    Mechanistic analysis of a copper-catalyzed C–H oxidative cyclization of carboxylic acids
  15. 6075
    “…Two new harziane diterpene lactones, possessing a 6/5/7/5-fused carbocyclic core containing a lactone ring system, harzianelactones A and B (1 and 2), and five new harziane diterpenes, harzianones A–D (3–6) and harziane (7), were isolated from the soft coral-derived fungus Trichoderma harzianum XS-20090075. …”
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    Potent Phytotoxic Harziane Diterpenes from a Soft Coral-Derived Strain of the Fungus Trichoderma harzianum XS-20090075
  16. 6076
    por Mattig, Thomas
    Publicado 2019
    “…In a federal state such as Switzerland, the 26 cantons enjoy wide autonomy in all policy areas, including health policy. …”
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    Coordinating health promotion in a federal state over the course of 30 years: a case report from Switzerland
  17. 6077
    “…The major constituent, C-10 Massoia lactone (C(10)H(16)O(2)) plays major role in exerting anticandida activity and potentially acts as an immunomodulator as well. …”
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    Potency of Massoia Bark in Combating Immunosuppressed-related Infection
  18. 6078
    “…Toxocara canis has a complex lifecycle including larval stages in the somatic tissue of dogs that tolerate macrocyclic lactones. In this study, we investigated T. canis permeability glycoproteins (P-gps, ABCB1) with a putative role in drug tolerance. …”
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    Repertoire of P-glycoprotein drug transporters in the zoonotic nematode Toxocara canis
  19. 6079
    “…This method helps in the putative characterization of sesquiterpene lactones, flavonoids, coumarate derivatives, and aliphatic compounds. …”
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    Isolation and LC-QToF Characterization of Secondary Metabolites from an Endemic Plant Artemisia heptapotamica Poljak
  20. 6080
    “…Seventy known metabolites including C(22) lactone sulfate and androgens were significantly associated with vitamin E supplementation. …”
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    Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
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