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  1. 6141
    “…Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. …”
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    Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview
  2. 6142
    “…Landon Myer and colleagues discuss viral load monitoring for pregnant HIV-positive women and those breastfeeding; ART treatments can suppress viral load and are key to preventing transmission to the child.…”
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    Pregnant and breastfeeding women: A priority population for HIV viral load monitoring
  3. 6143
    “…Swanton et al.(1) find that PM(2.5) exposure is associated with EGFR/KRAS-driven lung cancer incidence. …”
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    Air pollution, EGFR mutation, and cancer initiation
  4. 6144
    “…In the crystal structure of the title compound, C(15)H(22)O(2), the cyclo­hexene and cyclo­hexane rings adopt half-boat and chair conformations, respectively, and the lactone ring is in an envelope conformation.…”
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    6,6,9a-Trimethyl-5,5a,6,7,8,9,9a,9b-octa­hydro­naphtho[1,2-c]furan-1(3H)-one
  5. 6145
    “…Next, to test the ability of MFE01 to synthesize N-acyl homoserine lactones in our conditions, we investigated in silico the presence of corresponding genes across the MFE01 genome and we exposed its biofilms to an N-acyl homoserine lactone-degrading enzyme. …”
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    Pseudomonas fluorescens MFE01 uses 1-undecene as aerial communication molecule
  6. 6146
    “…In 2010, the Public Health Department of the canton of Vaud (Switzerland) launched a regional diabetes programme entitled “Programme cantonal Diabète” (PcD), with the objectives to both decrease the incidence of diabetes and improve care for patients with diabetes. …”
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    CoDiab-VD: protocol of a prospective population-based cohort study on diabetes care in Switzerland
  7. 6147
    por Bowman, Dwight D., Drake, Jason
    Publicado 2017
    “…Thus, no improvement in efficacy is expected with a delay in initiating therapy with both melarsomine dihydrochloride and macrocyclic lactones, even with the presence of younger heartworms. …”
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    Examination of the “susceptibility gap” in the treatment of canine heartworm infection
  8. 6148
    “…The proportion of individuals with fasting glucose ≥100 mg/dL did not differ by carrier status of G6PD-Canton (p=0.21). Whereas the proportion of individuals with HbA1c ≥5.7% units was lower in carriers (5%) compared with non-carriers of G6PD-Canton (30%, p=0.03). …”
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    Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals
  9. 6149
    “…SIMPLE SUMMARY: Scabertopin is one of the major sesquiterpene lactones from Elephantopus scaber L. Sesquiterpene lactones are thought to have fairly strong anti-cancer efficacy. …”
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    Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro
  10. 6150
    “…Tanacetum parthenium, also known as feverfew, is rich in bioactive compounds, namely sesquiterpene lactones, flavonoids, and volatile oils. Sesquiterpene lactones possess anti-migraine activity, while phenolic compounds possess anti-inflammatory and antioxidant action. …”
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    Phenolic Composition and Antioxidant Activity of Tanacetum parthenium Cultivated in Different Regions of Ukraine: Insights into the Flavonoids and Hydroxycinnamic Acids Profile
  11. 6151
    “…The dihedral angle between the ten-membered ring and the lactone ring is 27.93 (6)°. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen-bond inter­actions. …”
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    (Z)-6-Hy­droxy-1a,5-dimethyl-8-[(morpholin-4-yl)meth­yl]-2,3,6,7,7a,8,10a,10b-octa­hydro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-9(1aH)-one
  12. 6152
    “…The dihedral angle between the ten-membered ring and the lactone ring is 18.01 (19)°. An intra­molecular O—H⋯N hydrogen bond occurs. …”
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    9-Hy­droxy-4,8-dimethyl-12-(pyrrolidin-1-ylmeth­yl)-3,14-dioxatricyclo­[9.3.0.0(2,4)]tetra­dec-7-en-13-one
  13. 6153
    “…In addition, there is a tris­ubstituted furan ring, an approximately planar γ-lactone ring [maximum deviation of 0.057 (3) Å] and a pyraz­oline ring, the latter in an envelope conformation. …”
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    Kallolide A acetate pyrazoline
  14. 6154
    “…In the crystal, supra­molecular chains are formed along the a axis owing to C—H⋯O contacts, with the lactone carbonyl atom accepting two such bonds.…”
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    6-[(2E)-3,7-Dimethyl­octa-2,6-dien-1-yl]-5,7-dihy­droxy-8-(2-methyl­butano­yl)-4-phenyl-2H-chromen-2-one–6-[(2E)-3,7-dimethyl­octa-2,6-dien-1-yl]-5,7-dihy­droxy-8-(3-methyl­butano­yl)-4-phenyl-2H-chromen-2-one (1/1) from Mesua elegans
  15. 6155
    “…Among these was a structural class that has not yet been reported as rhomboid inhibitors: β-lactones. They form covalent and irreversible complexes with the active site serine of GlpG. …”
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    A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization
  16. 6156
    “…This kinetic resolution process led to the production of (1S,5R) normal lactone and (1R,5S) abnormal lactone with a regioisomeric ratio of 1:1 and 99% ee each. …”
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    Cloning, overexpression and biocatalytic exploration of a novel Baeyer-Villiger monooxygenase from Aspergillus fumigatus Af293
  17. 6157
    “…Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. …”
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    Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation
  18. 6158
    “…Whole genome analysis of this bacterial strain revealed the presence of an N-acyl homoserine lactonase, an enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs). Heterologous gene expression in E. coli confirmed its functions for hydrolysis of AHLs, and the gene was designated as aidP (autoinducer degrading gene from Planococcus sp.). …”
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    AidP, a novel N-Acyl homoserine lactonase gene from Antarctic Planococcus sp.
  19. 6159
    “…Two new monoterpenes, p-mentha-1(7),8-dien-2-O-β-d-glucoside (1) and trans-2,4-dihydroxy-2,4-dimethyl-trans-1-acetic acid γ-lactone (2) were isolated from the fruits of Illicium lanceolatum along with trans-2,4-dihydroxy-2,4-dimethyl-cis-1-acetic acid γ-lactone (3), (1R,2R,4R)-8-p-menthen-1,2-diol (4), trans-sobrerol (5), (1S,2S,4R)-p-menthane-1,2,8-triol (6) and (1S, 2S, 4R, 8R)-p-menthane-1,2,9-triol (7). …”
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    Two New Monoterpenes from the Fruits of Illicium lanceolatum
  20. 6160
    “…Michael addition of primary and secondary amines towards α,β-unsaturated γ-lactones was accomplished resulting in β-aminolactones in highly-stereoselective reactions. …”
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    Synthesis and Transformation of (-)-Isopulegol-Based Chiral β-Aminolactones and β-Aminoamides
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